FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109691722> ?p ?o ?g. }

• W2109691722 endingPage "1926" @default.
• W2109691722 startingPage "1919" @default.
• W2109691722 abstract "We have shown that a combination of fish oil (high in n-3 fatty acids) with the butyrate-producing fiber pectin, upregulates apoptosis in colon cells exposed to the carcinogen azoxymethane, protecting against colon tumor development. We now hypothesize that n-3 fatty acids prime the colonocytes such that butyrate can initiate apoptosis. To test this, 30 Sprague-Dawley rats were provided with diets differing in the fatty acid composition (corn oil, fish oil or a purified fatty acid ethyl ester diet). Intact colon crypts were exposed ex vivo to butyrate, and analyzed for reactive oxygen species (ROS), mitochondrial membrane potential (MMP), translocation of cytochrome C to the cytosol, and caspase-3 activity (early events in apoptosis). The fatty acid composition of the three major mitochondrial phospholipids was also determined, and an unsaturation index calculated. The unsaturation index in cardiolipin was correlated with ROS levels (R = 0.99; P = 0.02). When colon crypts from fish oil and FAEE-fed rats were exposed to butyrate, MMP decreased (P = 0.041); and translocation of cytochrome C to the cytosol (P = 0.037) and caspase-3 activation increased (P = 0.032). The data suggest that fish oil may prime the colonocytes for butyrate-induced apoptosis by enhancing the unsaturation of mitochondrial phospholipids, especially cardiolipin, resulting in an increase in ROS and initiating apoptotic cascade." @default.
• W2109691722 created "2016-06-24" @default.
• W2109691722 creator A5000822072 @default.
• W2109691722 creator A5011639404 @default.
• W2109691722 creator A5019568866 @default.
• W2109691722 creator A5020022933 @default.
• W2109691722 creator A5020568150 @default.
• W2109691722 creator A5020931465 @default.
• W2109691722 creator A5042078502 @default.
• W2109691722 creator A5047363205 @default.
• W2109691722 creator A5064099505 @default.
• W2109691722 creator A5067325195 @default.
• W2109691722 creator A5067428228 @default.
• W2109691722 creator A5070465724 @default.
• W2109691722 creator A5080214939 @default.
• W2109691722 date "2002-11-01" @default.
• W2109691722 modified "2023-09-24" @default.
• W2109691722 title "Fish oil increases mitochondrial phospholipid unsaturation, upregulating reactive oxygen species and apoptosis in rat colonocytes" @default.
• W2109691722 cites W1234816868 @default.
• W2109691722 cites W1433175440 @default.
• W2109691722 cites W1500405769 @default.
• W2109691722 cites W1562050716 @default.
• W2109691722 cites W1598136252 @default.
• W2109691722 cites W1776179263 @default.
• W2109691722 cites W1811302532 @default.
• W2109691722 cites W1901849592 @default.
• W2109691722 cites W1959894812 @default.
• W2109691722 cites W1963022907 @default.
• W2109691722 cites W1963649133 @default.
• W2109691722 cites W1964879817 @default.
• W2109691722 cites W1967066679 @default.
• W2109691722 cites W1970347121 @default.
• W2109691722 cites W1975020938 @default.
• W2109691722 cites W1988152364 @default.
• W2109691722 cites W1991679150 @default.
• W2109691722 cites W2030971565 @default.
• W2109691722 cites W2037614413 @default.
• W2109691722 cites W2039950693 @default.
• W2109691722 cites W2043820342 @default.
• W2109691722 cites W2044573147 @default.
• W2109691722 cites W2047231647 @default.
• W2109691722 cites W2057220797 @default.
• W2109691722 cites W2058181375 @default.
• W2109691722 cites W2075215849 @default.
• W2109691722 cites W2091665835 @default.
• W2109691722 cites W2100559721 @default.
• W2109691722 cites W2103540471 @default.
• W2109691722 cites W2105351634 @default.
• W2109691722 cites W2107221695 @default.
• W2109691722 cites W2113999599 @default.
• W2109691722 cites W2117165767 @default.
• W2109691722 cites W2136269407 @default.
• W2109691722 cites W2146559835 @default.
• W2109691722 cites W2157571295 @default.
• W2109691722 cites W2159309845 @default.
• W2109691722 cites W2167900530 @default.
• W2109691722 cites W2173513820 @default.
• W2109691722 cites W2187737240 @default.
• W2109691722 cites W2291903346 @default.
• W2109691722 cites W2292538025 @default.
• W2109691722 cites W2304048122 @default.
• W2109691722 cites W2338125648 @default.
• W2109691722 cites W3140464090 @default.
• W2109691722 cites W7449367 @default.
• W2109691722 doi "https://doi.org/10.1093/carcin/23.11.1919" @default.
• W2109691722 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12419841" @default.
• W2109691722 hasPublicationYear "2002" @default.
• W2109691722 type Work @default.
• W2109691722 sameAs 2109691722 @default.
• W2109691722 citedByCount "141" @default.
• W2109691722 countsByYear W21096917222012 @default.
• W2109691722 countsByYear W21096917222013 @default.
• W2109691722 countsByYear W21096917222014 @default.
• W2109691722 countsByYear W21096917222015 @default.
• W2109691722 countsByYear W21096917222016 @default.
• W2109691722 countsByYear W21096917222017 @default.
• W2109691722 countsByYear W21096917222018 @default.
• W2109691722 countsByYear W21096917222019 @default.
• W2109691722 countsByYear W21096917222020 @default.
• W2109691722 countsByYear W21096917222021 @default.
• W2109691722 countsByYear W21096917222022 @default.
• W2109691722 countsByYear W21096917222023 @default.
• W2109691722 crossrefType "journal-article" @default.
• W2109691722 hasAuthorship W2109691722A5000822072 @default.
• W2109691722 hasAuthorship W2109691722A5011639404 @default.
• W2109691722 hasAuthorship W2109691722A5019568866 @default.
• W2109691722 hasAuthorship W2109691722A5020022933 @default.
• W2109691722 hasAuthorship W2109691722A5020568150 @default.
• W2109691722 hasAuthorship W2109691722A5020931465 @default.
• W2109691722 hasAuthorship W2109691722A5042078502 @default.
• W2109691722 hasAuthorship W2109691722A5047363205 @default.
• W2109691722 hasAuthorship W2109691722A5064099505 @default.
• W2109691722 hasAuthorship W2109691722A5067325195 @default.
• W2109691722 hasAuthorship W2109691722A5067428228 @default.
• W2109691722 hasAuthorship W2109691722A5070465724 @default.
• W2109691722 hasAuthorship W2109691722A5080214939 @default.
• W2109691722 hasBestOaLocation W21096917221 @default.
• W2109691722 hasConcept C100544194 @default.

• next