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• W2109694557 abstract "Skin cancer accounts for 1/3 of all newly diagnosed cancer. Although seldom fatal, basal cell carcinoma (BCC) is associated with severe disfigurement and morbidity. BCC has a unique interest for researchers, as although it is often locally invasive, it rarely metastasises. This paper, reporting the first whole genome expression microarray analysis of skin cancer, aimed to investigate the molecular profile of BCC in comparison to non-cancerous skin biopsies. RNA from BCC and normal skin specimens was analysed using Affymetrix whole genome microarrays. A Welch t-test was applied to data normalised using dCHIP to identify significant differentially-expressed genes between BCC and normal specimens. Principal component analysis and support vector machine analysis were performed on resulting genelists, Genmapp was used to identify pathways affected, and GOstat aided identification of areas of gene ontology more highly represented on these lists than would be expected by chance. Following normalisation, specimens clustered into groups of BCC specimens and of normal skin specimens. Of the 54,675 gene transcripts/variants analysed, 3,921 were differentially expressed between BCC and normal skin specimens. Of these, 2,108 were significantly up-regulated and 1,813 were statistically significantly down-regulated in BCCs. Functional gene sets differentially expressed include those involved in transcription, proliferation, cell motility, apoptosis and metabolism. As expected, members of the Wnt and hedgehog pathways were found to be significantly different between BCC and normal specimens, as were many previously undescribed changes in gene expression between normal and BCC specimens, including basonuclin2 and mrp9. Quantitative-PCR analysis confirmed our microarray results, identifying novel potential biomarkers for BCC." @default.
• W2109694557 created "2016-06-24" @default.
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• W2109694557 date "2006-01-01" @default.
• W2109694557 modified "2023-10-15" @default.
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• W2109694557 cites W1817917437 @default.
• W2109694557 cites W1829979159 @default.
• W2109694557 cites W1927182755 @default.
• W2109694557 cites W1970671407 @default.
• W2109694557 cites W1972046720 @default.
• W2109694557 cites W1977464187 @default.
• W2109694557 cites W1985086204 @default.
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• W2109694557 cites W1996940506 @default.
• W2109694557 cites W1998700764 @default.
• W2109694557 cites W2005064657 @default.
• W2109694557 cites W2009708658 @default.
• W2109694557 cites W2033271766 @default.
• W2109694557 cites W2034141930 @default.
• W2109694557 cites W2038437697 @default.
• W2109694557 cites W2038912121 @default.
• W2109694557 cites W2042117849 @default.
• W2109694557 cites W2042427864 @default.
• W2109694557 cites W2051252658 @default.
• W2109694557 cites W2060734249 @default.
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• W2109694557 cites W2065278544 @default.
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• W2109694557 cites W2073409586 @default.
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• W2109694557 cites W2080795113 @default.
• W2109694557 cites W2083810849 @default.
• W2109694557 cites W2086539941 @default.
• W2109694557 cites W2088113039 @default.
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• W2109694557 cites W2096757580 @default.
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• W2109694557 cites W2138188580 @default.
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• W2109694557 cites W2145323427 @default.
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• W2109694557 cites W2319385029 @default.
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• W2109694557 cites W2417318135 @default.
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• W2109694557 doi "https://doi.org/10.1186/1476-4598-5-74" @default.
• W2109694557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1770933" @default.
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• W2109694557 hasPublicationYear "2006" @default.
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