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• W2109698834 abstract "Clonidine in paediatric anaesthesia: Pharmacokinetic and pharmacodynamic aspects. Henrik TG Bergendahl. Stockholm 2002. Clonidine is a mixed alpha-2/alpha-1 adrenoceptor agonist. It reduces sympathetic and increases parasympathetic tone which results in a lowering of the baseline blood pressure and heart rate. Descending postjunctional noradrenergic antinociceptive pathways originating in the brainstem are believed to contribute to pain control of both nociceptive and neuropathic origin after clonidine challenge. The sedative effect of clonidine is due to alpha-2 adrenoceptor stimulation in the locus coeruleus. In adults, oral clonidine provides preoperative sedation, increases perioperative haemodynamic stability, reduces the requirements of volatile anaesthetic requirements, and attenuates the stress response secondary to intubation. A pure analgesic effect is seen after both systemic and neuraxial administration. In paediatric anaesthesia similar beneficial effects have been observed. To provide safe and effective use of clonidine in children further studies delineating its specific pharmacokinetic and haemodynamic characteristics are needed, despite its recently increased clinical use. Randomised controlled trials comparing the clinical use of clonidine as a premedicant drug to the currently widely used premedicant gold standard represented by midazolam are warranted. The primary aims of this dissertation were to describe the pharmacokinetics after different routes of administrations and delineate the intraoperative haemodynamic profile. The magnitude of the stress-response caused by endotracheal intubation with special emphasis on the Neuropeptide Y response was compared after premedication with low-dose clonidine and midazolam. The postoperative analgesic and sedative effects of clonidine after epidural co-administration together with bupivacaine has also been evaluated. The influence of epidural co-infusion of clonidine and ropivacaine on postoperative blood pressure variability was furthermore investigated. Effects on postoperative analgesia, sedation, delirium, shivering and postoperative vomiting after premedication with clonidine and midazolam were compared. Clonidine analysis was made by radioimmunoassay. NPY was analysed with a competitive radioimmunoassay. Postoperative analgesia was assessed by Objective Pain Scale and sedation was assessed by the Vancouver Sedative Recovery Scale. A new statistical procedure for calculations of bioavailability from two independent populations was introduced. Parental preferences were assessed using a written questionnaire. In total 238 children, age 1-10 years, were included in seven different studies. The haemodynamic response after clonidine administration was moderate and should be well tolerated in otherwise healthy children. Epidural clonidine improves blood pressure stability by reducing blood pressure variability. The pharmacokinetic profile after intravenous, rectal, and epidural administration were similar to that reported in adults. We therefore conclude that there are no pharmacokinetic or haemodynamic aspects contraindicating further use of clonidine in paediatric anaesthesia. The stress response after endotracheal intubation is of only moderate magnitude, as indicated by the lack of NPY release, and is not attenuated by low dose of clonidine. Rectal administration of clonidine was associated with a significant reduction of pain scores in the early postoperative period following adenotonsillectomy when compared to rectal midazolam. The analgesic effect seen after epidural and rectal clonidine cannot be explained by residual sedation alone. The use of clonidine is also associated with slightly increased sedation ratings during the first 24 postoperative hours compared to midazolam. However, this observation is in agreement with the unequivocal parental preference of a calm and sedated child during the early post-operative time period. Based on our own results, as well as data published by other research groups, we conclude that clonidine represents a useful pharmacological alternative in paediatric anaesthesia." @default.
• W2109698834 created "2016-06-24" @default.
• W2109698834 creator A5026618096 @default.
• W2109698834 date "2002-04-12" @default.
• W2109698834 modified "2023-09-23" @default.
• W2109698834 title "Clonidine in paediatric anaesthesia: : Pharmacokinetic and pharmacodynamic aspects" @default.
• W2109698834 cites W102964479 @default.
• W2109698834 cites W119905122 @default.
• W2109698834 cites W130740266 @default.
• W2109698834 cites W144174057 @default.
• W2109698834 cites W1525026588 @default.
• W2109698834 cites W1527556194 @default.
• W2109698834 cites W1544197342 @default.
• W2109698834 cites W1549476547 @default.
• W2109698834 cites W1559778399 @default.
• W2109698834 cites W1577776410 @default.
• W2109698834 cites W1653226483 @default.
• W2109698834 cites W1674439747 @default.
• W2109698834 cites W1680907943 @default.
• W2109698834 cites W168372348 @default.
• W2109698834 cites W171255879 @default.
• W2109698834 cites W183361910 @default.
• W2109698834 cites W1851466778 @default.
• W2109698834 cites W1867384414 @default.
• W2109698834 cites W1896831793 @default.
• W2109698834 cites W1906189148 @default.
• W2109698834 cites W191377282 @default.
• W2109698834 cites W1937891769 @default.
• W2109698834 cites W1965953866 @default.
• W2109698834 cites W1966540872 @default.
• W2109698834 cites W1966704497 @default.
• W2109698834 cites W1966891252 @default.
• W2109698834 cites W1967355349 @default.
• W2109698834 cites W1967722117 @default.
• W2109698834 cites W1968423274 @default.
• W2109698834 cites W1968535715 @default.
• W2109698834 cites W1969635202 @default.
• W2109698834 cites W1969822824 @default.
• W2109698834 cites W1969927294 @default.
• W2109698834 cites W1970837652 @default.
• W2109698834 cites W1971077539 @default.
• W2109698834 cites W1971865860 @default.
• W2109698834 cites W1972434294 @default.
• W2109698834 cites W1973854659 @default.
• W2109698834 cites W1975972581 @default.
• W2109698834 cites W1976972125 @default.
• W2109698834 cites W1977333903 @default.
• W2109698834 cites W1978736571 @default.
• W2109698834 cites W1979955365 @default.
• W2109698834 cites W1980086437 @default.
• W2109698834 cites W1980115830 @default.
• W2109698834 cites W1980253766 @default.
• W2109698834 cites W1980514719 @default.
• W2109698834 cites W1981468043 @default.
• W2109698834 cites W1981648776 @default.
• W2109698834 cites W1981960803 @default.
• W2109698834 cites W1982639528 @default.
• W2109698834 cites W1983389000 @default.
• W2109698834 cites W1984273331 @default.
• W2109698834 cites W1985494567 @default.
• W2109698834 cites W1985561148 @default.
• W2109698834 cites W1985949691 @default.
• W2109698834 cites W1986498669 @default.
• W2109698834 cites W1986986729 @default.
• W2109698834 cites W1989064293 @default.
• W2109698834 cites W1989532112 @default.
• W2109698834 cites W1989721871 @default.
• W2109698834 cites W1990692499 @default.
• W2109698834 cites W1991086949 @default.
• W2109698834 cites W1992196946 @default.
• W2109698834 cites W1992533950 @default.
• W2109698834 cites W1993204674 @default.
• W2109698834 cites W1993412546 @default.
• W2109698834 cites W1993430458 @default.
• W2109698834 cites W1995239949 @default.
• W2109698834 cites W1995385744 @default.
• W2109698834 cites W1995432167 @default.
• W2109698834 cites W1995545137 @default.
• W2109698834 cites W1997761599 @default.
• W2109698834 cites W1998514242 @default.
• W2109698834 cites W1999079648 @default.
• W2109698834 cites W1999167442 @default.
• W2109698834 cites W1999269596 @default.
• W2109698834 cites W1999776567 @default.
• W2109698834 cites W2000247756 @default.
• W2109698834 cites W2000500546 @default.
• W2109698834 cites W2001063032 @default.
• W2109698834 cites W2001126418 @default.
• W2109698834 cites W2001426739 @default.
• W2109698834 cites W2002294075 @default.
• W2109698834 cites W2003209727 @default.
• W2109698834 cites W2003574523 @default.
• W2109698834 cites W2003775890 @default.
• W2109698834 cites W2004710233 @default.
• W2109698834 cites W2005181906 @default.
• W2109698834 cites W2008411223 @default.
• W2109698834 cites W2009580792 @default.
• W2109698834 cites W2012140737 @default.
• W2109698834 cites W2012190898 @default.
• W2109698834 cites W2012335673 @default.

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