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- W2109711739 abstract "The detection of an over-represented sub-sequence in a set of (carefully chosen) DNA sequences is often the main clue leading to the investigation of a possible functional role for such a subsequence. Over-represented substrings (with possibly local mutations) in a biological string are termed motifs. A typical functional unit that can be modeled by a motif is a Transcription Factor Binding Site (TFBS), a portion of the DNA sequence apt to the binding of a protein that participates in complex transcriptomic biochemical reactions. In the literature it has been proposed a simplified combinatorial problem called the planted (l-d)-motif problem (known also as the (l-d) Challenge Problem) that captures the essential combinatorial nature of the motif finding problem. In this paper we propose a novel graph-based algorithm for solving a refinement of the (l-d) Challenge Problem. Experimental results show that instances of the (l-d) Challenge Problem considered difficult for competing state of the art methods in literature can be solved efficiently in our framework." @default.
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- W2109711739 date "2009-01-01" @default.
- W2109711739 modified "2023-09-25" @default.
- W2109711739 title "An Efficient Combinatorial Approach for Solving the DNA Motif Finding Problem" @default.
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- W2109711739 doi "https://doi.org/10.1109/isda.2009.41" @default.
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