FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109718825> ?p ?o ?g. }

• W2109718825 endingPage "1722" @default.
• W2109718825 startingPage "1714" @default.
• W2109718825 abstract "ABSTRACT The Ral proteins are members of the Ras superfamily of GTPases. Because they reside in synaptic vesicles, we used transgenic mice expressing a dominant inhibitory form of Ral to investigate the role of Ral in neurosecretion. Using a synaptosomal secretion assay, we found that while K + -evoked secretion of glutamate was normal, protein kinase C-mediated enhancement of glutamate secretion was suppressed in the mutant mice. Since protein kinase C effects on secretion have been shown to be due to enhancement of the size of the readily releasable pool of synaptic vesicles docked at the plasma membrane, we directly measured the refilling of this readily releasable pool of synaptic vesicles after Ca 2+ -triggered exocytosis. Refilling of the readily releasable pool was suppressed in synaptosomes from mice expressing dominant inhibitory Ral. Moreover, we found that protein kinase C and calcium-induced phosphorylation of proteins thought to influence synaptic vesicle function, such as MARCKS, synapsin, and SNAP-25, were all reduced in synaptosomes from these transgenic mice. Concomitant with these studies, we searched for new functions of Ral by detecting proteins that specifically bind to it in cells. Consistent with the phenotype of the transgenic mice described above, we found that active but not inactive RalA binds to the Sec6/8 (exocyst) complex, whose yeast counterpart is essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. These findings demonstrate a role for Ral-GTPase signaling in the modulation of the readily releasable pool of synaptic vesicles and suggest the possible involvement of Ral-Sec6/8 (exocyst) binding in modulation of synaptic strength." @default.
• W2109718825 created "2016-06-24" @default.
• W2109718825 creator A5022175836 @default.
• W2109718825 creator A5026576967 @default.
• W2109718825 creator A5042852320 @default.
• W2109718825 creator A5075657062 @default.
• W2109718825 creator A5080245027 @default.
• W2109718825 date "2002-03-01" @default.
• W2109718825 modified "2023-10-16" @default.
• W2109718825 title "Ral-GTPase Influences the Regulation of the Readily Releasable Pool of Synaptic Vesicles" @default.
• W2109718825 cites W1508614407 @default.
• W2109718825 cites W1523918896 @default.
• W2109718825 cites W1608131302 @default.
• W2109718825 cites W1943068820 @default.
• W2109718825 cites W1965522502 @default.
• W2109718825 cites W1975086853 @default.
• W2109718825 cites W1976331372 @default.
• W2109718825 cites W1982474924 @default.
• W2109718825 cites W1999127875 @default.
• W2109718825 cites W2001520037 @default.
• W2109718825 cites W2007375100 @default.
• W2109718825 cites W2010767308 @default.
• W2109718825 cites W2011298151 @default.
• W2109718825 cites W2013541506 @default.
• W2109718825 cites W2013907969 @default.
• W2109718825 cites W2017550542 @default.
• W2109718825 cites W2018991789 @default.
• W2109718825 cites W2019016101 @default.
• W2109718825 cites W2020869636 @default.
• W2109718825 cites W2026403140 @default.
• W2109718825 cites W2028643767 @default.
• W2109718825 cites W2032817187 @default.
• W2109718825 cites W2045407209 @default.
• W2109718825 cites W2051620676 @default.
• W2109718825 cites W2054886459 @default.
• W2109718825 cites W2055374196 @default.
• W2109718825 cites W2061260576 @default.
• W2109718825 cites W2062016454 @default.
• W2109718825 cites W2064829142 @default.
• W2109718825 cites W2066791280 @default.
• W2109718825 cites W2067407535 @default.
• W2109718825 cites W2068137415 @default.
• W2109718825 cites W2073612561 @default.
• W2109718825 cites W2076776277 @default.
• W2109718825 cites W2078948761 @default.
• W2109718825 cites W2090662268 @default.
• W2109718825 cites W2093013340 @default.
• W2109718825 cites W2108632260 @default.
• W2109718825 cites W2109110743 @default.
• W2109718825 cites W2117305619 @default.
• W2109718825 cites W2123557321 @default.
• W2109718825 cites W2139112892 @default.
• W2109718825 cites W2152220855 @default.
• W2109718825 cites W2153604383 @default.
• W2109718825 cites W2154425220 @default.
• W2109718825 cites W2163589581 @default.
• W2109718825 cites W2180781622 @default.
• W2109718825 cites W2234669619 @default.
• W2109718825 doi "https://doi.org/10.1128/mcb.22.6.1714-1722.2002" @default.
• W2109718825 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/135608" @default.
• W2109718825 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11865051" @default.
• W2109718825 hasPublicationYear "2002" @default.
• W2109718825 type Work @default.
• W2109718825 sameAs 2109718825 @default.
• W2109718825 citedByCount "79" @default.
• W2109718825 countsByYear W21097188252012 @default.
• W2109718825 countsByYear W21097188252013 @default.
• W2109718825 countsByYear W21097188252015 @default.
• W2109718825 countsByYear W21097188252016 @default.
• W2109718825 countsByYear W21097188252017 @default.
• W2109718825 countsByYear W21097188252018 @default.
• W2109718825 countsByYear W21097188252019 @default.
• W2109718825 countsByYear W21097188252021 @default.
• W2109718825 countsByYear W21097188252022 @default.
• W2109718825 crossrefType "journal-article" @default.
• W2109718825 hasAuthorship W2109718825A5022175836 @default.
• W2109718825 hasAuthorship W2109718825A5026576967 @default.
• W2109718825 hasAuthorship W2109718825A5042852320 @default.
• W2109718825 hasAuthorship W2109718825A5075657062 @default.
• W2109718825 hasAuthorship W2109718825A5080245027 @default.
• W2109718825 hasBestOaLocation W21097188251 @default.
• W2109718825 hasConcept C12554922 @default.
• W2109718825 hasConcept C130316041 @default.
• W2109718825 hasConcept C148785051 @default.
• W2109718825 hasConcept C207332259 @default.
• W2109718825 hasConcept C2780298669 @default.
• W2109718825 hasConcept C41625074 @default.
• W2109718825 hasConcept C54355233 @default.
• W2109718825 hasConcept C62478195 @default.
• W2109718825 hasConcept C86803240 @default.
• W2109718825 hasConcept C95444343 @default.
• W2109718825 hasConceptScore W2109718825C12554922 @default.
• W2109718825 hasConceptScore W2109718825C130316041 @default.
• W2109718825 hasConceptScore W2109718825C148785051 @default.
• W2109718825 hasConceptScore W2109718825C207332259 @default.
• W2109718825 hasConceptScore W2109718825C2780298669 @default.
• W2109718825 hasConceptScore W2109718825C41625074 @default.
• W2109718825 hasConceptScore W2109718825C54355233 @default.

• next