FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109719586> ?p ?o ?g. }

• W2109719586 endingPage "257" @default.
• W2109719586 startingPage "248" @default.
• W2109719586 abstract "CD8 + cytotoxic T lymphocytes contribute to viral and autoimmune myocarditis and cardiac allograft rejection. The role of cytotoxic T-lymphocyte–associated antigen (CTLA)-4 as a negative regulator of CD4 + T cells is well defined, yet CTLA-4 regulation of CD8 + T cells is less clear. We studied CTLA-4 regulation of cytotoxic T lymphocytes in a transgenic model of CD8 + T-cell–mediated myocarditis. We generated CTLA-4 −/− Rag 2 −/− OT-1 mice, the CD8 + T cells of which express an ovalbumin (OVA) peptide-specific, class I major histocompatibility complex–restricted T-cell receptor. CTLA-4 −/−Tc12 OT-1 effectors, differentiated with interleukin-12 present, are hyperproliferative in vitro, compared with CTLA-4 +/+ Tc12 OT-1 controls. Transfer of low doses of CTLA-4 −/−Tc12 OT-1 cells to cMy-mOVA mice, which express OVA on cardiac myocytes, causes severe myocarditis, with 99% mortality, compared with no mortality after transfer of low doses of CTLA-4 +/+ Tc12 OT-1 cells. High doses of CTLA-4 +/+ Tc12 cells cause lethal myocarditis in cMy-mOVA mice, but high doses of CTLA-4 +/+ Tc0 CTL, generated without interleukin-12, are hypoproliferative within the cardiac-draining lymph node and do not significantly infiltrate the heart. In contrast, CTLA-4 −/−Tc0 cytotoxic T lymphocytes do proliferate in the cardiac-draining lymph node and diffusely infiltrate the heart. Nonetheless, high doses of CTLA-4 −/−Tc0 cells cause only limited tissue damage, and the disease is not lethal. These data show that CTLA-4 regulates myocarditic CD8 + T cell responses and that CTLA-4 deficiency partly overcomes a differentiation block that exists when naïve CD8 + T cells are stimulated without interleukin-12. Therefore, targeting CTLA-4 solely or in conjunction with interleukin-12 could influence effector CD8 + T cell responses in therapeutically beneficial ways." @default.
• W2109719586 created "2016-06-24" @default.
• W2109719586 creator A5003017337 @default.
• W2109719586 creator A5028781571 @default.
• W2109719586 creator A5029116436 @default.
• W2109719586 creator A5044052948 @default.
• W2109719586 creator A5067352687 @default.
• W2109719586 creator A5086080792 @default.
• W2109719586 date "2007-08-03" @default.
• W2109719586 modified "2023-10-12" @default.
• W2109719586 title "CTLA-4 Ablation and Interleukin-12–Driven Differentiation Synergistically Augment Cardiac Pathogenicity of Cytotoxic T Lymphocytes" @default.
• W2109719586 cites W1489480103 @default.
• W2109719586 cites W1522294823 @default.
• W2109719586 cites W1629380315 @default.
• W2109719586 cites W1672727064 @default.
• W2109719586 cites W1819681752 @default.
• W2109719586 cites W1959677146 @default.
• W2109719586 cites W1964934179 @default.
• W2109719586 cites W1981375682 @default.
• W2109719586 cites W2015085911 @default.
• W2109719586 cites W2017861959 @default.
• W2109719586 cites W2021818331 @default.
• W2109719586 cites W2029205604 @default.
• W2109719586 cites W2041323983 @default.
• W2109719586 cites W2042031899 @default.
• W2109719586 cites W2072077104 @default.
• W2109719586 cites W2076067786 @default.
• W2109719586 cites W2080435444 @default.
• W2109719586 cites W2090077005 @default.
• W2109719586 cites W2103565638 @default.
• W2109719586 cites W2109556041 @default.
• W2109719586 cites W2114587993 @default.
• W2109719586 cites W2119936827 @default.
• W2109719586 cites W2127454051 @default.
• W2109719586 cites W2130901500 @default.
• W2109719586 cites W2132249471 @default.
• W2109719586 cites W2136183100 @default.
• W2109719586 cites W2139434414 @default.
• W2109719586 cites W2143467222 @default.
• W2109719586 cites W2146887062 @default.
• W2109719586 cites W2146934604 @default.
• W2109719586 cites W2157131957 @default.
• W2109719586 cites W2162196408 @default.
• W2109719586 cites W2165521534 @default.
• W2109719586 cites W2269774696 @default.
• W2109719586 cites W4235618655 @default.
• W2109719586 cites W4238582550 @default.
• W2109719586 doi "https://doi.org/10.1161/circresaha.106.147124" @default.
• W2109719586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17569889" @default.
• W2109719586 hasPublicationYear "2007" @default.
• W2109719586 type Work @default.
• W2109719586 sameAs 2109719586 @default.
• W2109719586 citedByCount "67" @default.
• W2109719586 countsByYear W21097195862013 @default.
• W2109719586 countsByYear W21097195862015 @default.
• W2109719586 countsByYear W21097195862016 @default.
• W2109719586 countsByYear W21097195862017 @default.
• W2109719586 countsByYear W21097195862018 @default.
• W2109719586 countsByYear W21097195862019 @default.
• W2109719586 countsByYear W21097195862020 @default.
• W2109719586 countsByYear W21097195862021 @default.
• W2109719586 countsByYear W21097195862022 @default.
• W2109719586 countsByYear W21097195862023 @default.
• W2109719586 crossrefType "journal-article" @default.
• W2109719586 hasAuthorship W2109719586A5003017337 @default.
• W2109719586 hasAuthorship W2109719586A5028781571 @default.
• W2109719586 hasAuthorship W2109719586A5029116436 @default.
• W2109719586 hasAuthorship W2109719586A5044052948 @default.
• W2109719586 hasAuthorship W2109719586A5067352687 @default.
• W2109719586 hasAuthorship W2109719586A5086080792 @default.
• W2109719586 hasBestOaLocation W21097195861 @default.
• W2109719586 hasConcept C126322002 @default.
• W2109719586 hasConcept C129374314 @default.
• W2109719586 hasConcept C147483822 @default.
• W2109719586 hasConcept C154317977 @default.
• W2109719586 hasConcept C167672396 @default.
• W2109719586 hasConcept C202751555 @default.
• W2109719586 hasConcept C203014093 @default.
• W2109719586 hasConcept C21705690 @default.
• W2109719586 hasConcept C2776090121 @default.
• W2109719586 hasConcept C2780875844 @default.
• W2109719586 hasConcept C55493867 @default.
• W2109719586 hasConcept C71924100 @default.
• W2109719586 hasConcept C86803240 @default.
• W2109719586 hasConcept C8891405 @default.
• W2109719586 hasConcept C90375314 @default.
• W2109719586 hasConceptScore W2109719586C126322002 @default.
• W2109719586 hasConceptScore W2109719586C129374314 @default.
• W2109719586 hasConceptScore W2109719586C147483822 @default.
• W2109719586 hasConceptScore W2109719586C154317977 @default.
• W2109719586 hasConceptScore W2109719586C167672396 @default.
• W2109719586 hasConceptScore W2109719586C202751555 @default.
• W2109719586 hasConceptScore W2109719586C203014093 @default.
• W2109719586 hasConceptScore W2109719586C21705690 @default.
• W2109719586 hasConceptScore W2109719586C2776090121 @default.
• W2109719586 hasConceptScore W2109719586C2780875844 @default.
• W2109719586 hasConceptScore W2109719586C55493867 @default.
• W2109719586 hasConceptScore W2109719586C71924100 @default.

• next