FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109751424> ?p ?o ?g. }

• W2109751424 endingPage "212" @default.
• W2109751424 startingPage "200" @default.
• W2109751424 abstract "A new diabetic mouse strain, the Akita.PlGF knockout ((-/-)), was generated to study the role of placental growth factor (PlGF) in the pathogenesis of diabetic retinopathy (DR). PlGF deletion did not affect blood glucose but reduced the body weight of Akita.PlGF(-/-) mice. Diabetes-induced retinal cell death, capillary degeneration, pericyte loss, and blood-retinal barrier breakdown were prevented in these mice. Protein expression of PlGF was upregulated by diabetes, particularly in vascular cells. Diabetes-induced degradation of ZO-1 and VE-cadherin was reversed due to PlGF deficiency; their expression was correlated with that of sonic hedgehog and angiopoietin-1. PlGF deletion in Akita mice resulted in an increased Akt phosphorylation. Diabetes-activated hypoxia-inducible factor (HIF)1α-vascular endothelial growth factor (VEGF) pathway, including expression of HIF1α, VEGF, VEGFR1-3, and the extent of phospho (p)-VEGFR1, p-VEGFR2, and p-endothelial nitric oxide synthase, was inhibited in the retinas of diabetic PlGF(-/-) mice. However, expression of intercellular adhesion molecule-1, vascular cell adhesion molecule-1, CD11b, and CD18 was not inhibited by PlGF deletion, nor was retinal leukostasis. These results suggest that PlGF is critical for the development of DR, and its genetic deletion protects the retina from diabetic damage. Protective mechanisms are associated with Akt activation and HIF1α-VEGF pathway inhibition, but independent of retinal leukostasis in the retinas of diabetic PlGF(-/-) mice." @default.
• W2109751424 created "2016-06-24" @default.
• W2109751424 creator A5003525166 @default.
• W2109751424 creator A5014071864 @default.
• W2109751424 creator A5016107456 @default.
• W2109751424 creator A5029506023 @default.
• W2109751424 creator A5035520440 @default.
• W2109751424 creator A5037759802 @default.
• W2109751424 creator A5038705079 @default.
• W2109751424 creator A5047152113 @default.
• W2109751424 creator A5057025393 @default.
• W2109751424 creator A5091860889 @default.
• W2109751424 date "2014-09-03" @default.
• W2109751424 modified "2023-10-15" @default.
• W2109751424 title "Deletion of Placental Growth Factor Prevents Diabetic Retinopathy and Is Associated With Akt Activation and HIF1α-VEGF Pathway Inhibition" @default.
• W2109751424 cites W1875554126 @default.
• W2109751424 cites W1969536547 @default.
• W2109751424 cites W1969858778 @default.
• W2109751424 cites W1981141390 @default.
• W2109751424 cites W1981670613 @default.
• W2109751424 cites W1985388968 @default.
• W2109751424 cites W2004523281 @default.
• W2109751424 cites W2009996262 @default.
• W2109751424 cites W2013141629 @default.
• W2109751424 cites W2013517841 @default.
• W2109751424 cites W2014148719 @default.
• W2109751424 cites W2018141371 @default.
• W2109751424 cites W2019842407 @default.
• W2109751424 cites W2029089767 @default.
• W2109751424 cites W2029114316 @default.
• W2109751424 cites W2029763523 @default.
• W2109751424 cites W2033820137 @default.
• W2109751424 cites W2035899769 @default.
• W2109751424 cites W2036496650 @default.
• W2109751424 cites W2046571308 @default.
• W2109751424 cites W2049624292 @default.
• W2109751424 cites W2065679638 @default.
• W2109751424 cites W2067626374 @default.
• W2109751424 cites W2068224058 @default.
• W2109751424 cites W2086411318 @default.
• W2109751424 cites W2087409531 @default.
• W2109751424 cites W2088166206 @default.
• W2109751424 cites W2092348954 @default.
• W2109751424 cites W2094957208 @default.
• W2109751424 cites W2103122477 @default.
• W2109751424 cites W2104301336 @default.
• W2109751424 cites W2111009402 @default.
• W2109751424 cites W2115420079 @default.
• W2109751424 cites W2138125744 @default.
• W2109751424 cites W2141201649 @default.
• W2109751424 cites W2141852514 @default.
• W2109751424 cites W2157087666 @default.
• W2109751424 cites W2335019216 @default.
• W2109751424 cites W4244017022 @default.
• W2109751424 doi "https://doi.org/10.2337/db14-0016" @default.
• W2109751424 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4274802" @default.
• W2109751424 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25187372" @default.
• W2109751424 hasPublicationYear "2014" @default.
• W2109751424 type Work @default.
• W2109751424 sameAs 2109751424 @default.
• W2109751424 citedByCount "109" @default.
• W2109751424 countsByYear W21097514242013 @default.
• W2109751424 countsByYear W21097514242014 @default.
• W2109751424 countsByYear W21097514242015 @default.
• W2109751424 countsByYear W21097514242016 @default.
• W2109751424 countsByYear W21097514242017 @default.
• W2109751424 countsByYear W21097514242018 @default.
• W2109751424 countsByYear W21097514242019 @default.
• W2109751424 countsByYear W21097514242020 @default.
• W2109751424 countsByYear W21097514242021 @default.
• W2109751424 countsByYear W21097514242022 @default.
• W2109751424 countsByYear W21097514242023 @default.
• W2109751424 crossrefType "journal-article" @default.
• W2109751424 hasAuthorship W2109751424A5003525166 @default.
• W2109751424 hasAuthorship W2109751424A5014071864 @default.
• W2109751424 hasAuthorship W2109751424A5016107456 @default.
• W2109751424 hasAuthorship W2109751424A5029506023 @default.
• W2109751424 hasAuthorship W2109751424A5035520440 @default.
• W2109751424 hasAuthorship W2109751424A5037759802 @default.
• W2109751424 hasAuthorship W2109751424A5038705079 @default.
• W2109751424 hasAuthorship W2109751424A5047152113 @default.
• W2109751424 hasAuthorship W2109751424A5057025393 @default.
• W2109751424 hasAuthorship W2109751424A5091860889 @default.
• W2109751424 hasBestOaLocation W21097514241 @default.
• W2109751424 hasConcept C126322002 @default.
• W2109751424 hasConcept C134018914 @default.
• W2109751424 hasConcept C146285616 @default.
• W2109751424 hasConcept C167734588 @default.
• W2109751424 hasConcept C2776871010 @default.
• W2109751424 hasConcept C2777025900 @default.
• W2109751424 hasConcept C2777432695 @default.
• W2109751424 hasConcept C2778371105 @default.
• W2109751424 hasConcept C2778461978 @default.
• W2109751424 hasConcept C2779094623 @default.
• W2109751424 hasConcept C2779829184 @default.
• W2109751424 hasConcept C555293320 @default.
• W2109751424 hasConcept C71924100 @default.
• W2109751424 hasConceptScore W2109751424C126322002 @default.

• next