FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109765271> ?p ?o ?g. }

• W2109765271 endingPage "206" @default.
• W2109765271 startingPage "194" @default.
• W2109765271 abstract "Tolerance to physiological stress resulting from inflammatory disease decreases significantly with age. High mortality rates, increased cytokine production, and pronounced thrombosis are characteristic complications of aged mice with acute systemic inflammation induced by injection with lipopolysaccharide (LPS). As adipose tissue is now recognized as an important source of cytokines, we determined the effects of aging on visceral white adipose tissue gene expression during LPS-induced inflammation in male C57BL/6 mice. Microarray analysis revealed that the expression of 6025 genes was significantly changed by LPS; of those, the expression of 667 showed an age-associated difference. Age-associated differences were found in many genes belonging to the inflammatory response and blood clotting pathways. Genes for several procoagulant factors were upregulated by LPS; among these, tissue factor, thrombospondin-1, and plasminogen activator inhibitors-1 and -2, exhibited age-associated increases in expression which could potentially contribute to augmented thrombosis. Further analysis by qRT-PCR, histological examination, and cell fraction separation revealed that most inflammatory and coagulant-related gene expression changes occur in resident stromal cells rather than adipocytes or infiltrating cells. In addition, basal expression levels of 303 genes were altered by aging, including increased expression of component of Sp100-rs (Csprs). This study indicates that adipose tissue is a major organ expressing genes for multiple inflammatory and coagulant factors and that the expression of many of these is significantly altered by aging during acute inflammation. Data presented here provide a framework for future studies aimed at elucidating the impact of adipose tissue on age-associated complications during sepsis and systemic inflammation." @default.
• W2109765271 created "2016-06-24" @default.
• W2109765271 creator A5015410806 @default.
• W2109765271 creator A5018970596 @default.
• W2109765271 creator A5045786709 @default.
• W2109765271 creator A5066347342 @default.
• W2109765271 creator A5067935460 @default.
• W2109765271 creator A5072669719 @default.
• W2109765271 creator A5080661141 @default.
• W2109765271 date "2013-01-30" @default.
• W2109765271 modified "2023-10-16" @default.
• W2109765271 title "Gene expression profile of mouse white adipose tissue during inflammatory stress: age-dependent upregulation of major procoagulant factors" @default.
• W2109765271 cites W104376487 @default.
• W2109765271 cites W1508151107 @default.
• W2109765271 cites W1607100760 @default.
• W2109765271 cites W1638473681 @default.
• W2109765271 cites W1970757590 @default.
• W2109765271 cites W1992281814 @default.
• W2109765271 cites W1992621343 @default.
• W2109765271 cites W1993567092 @default.
• W2109765271 cites W2009248160 @default.
• W2109765271 cites W2015141049 @default.
• W2109765271 cites W2019735686 @default.
• W2109765271 cites W2021239799 @default.
• W2109765271 cites W2034413738 @default.
• W2109765271 cites W2040901874 @default.
• W2109765271 cites W2048101387 @default.
• W2109765271 cites W2049927822 @default.
• W2109765271 cites W2052429062 @default.
• W2109765271 cites W2054059581 @default.
• W2109765271 cites W2070454941 @default.
• W2109765271 cites W2080643114 @default.
• W2109765271 cites W2088205404 @default.
• W2109765271 cites W2091577537 @default.
• W2109765271 cites W2105974518 @default.
• W2109765271 cites W2106323366 @default.
• W2109765271 cites W2111636390 @default.
• W2109765271 cites W2129203245 @default.
• W2109765271 cites W2131250713 @default.
• W2109765271 cites W2131989143 @default.
• W2109765271 cites W2137309569 @default.
• W2109765271 cites W2144211575 @default.
• W2109765271 cites W2145724295 @default.
• W2109765271 cites W2151115776 @default.
• W2109765271 cites W2154268935 @default.
• W2109765271 cites W2165678812 @default.
• W2109765271 cites W2169382147 @default.
• W2109765271 doi "https://doi.org/10.1111/acel.12040" @default.
• W2109765271 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3633415" @default.
• W2109765271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23279636" @default.
• W2109765271 hasPublicationYear "2013" @default.
• W2109765271 type Work @default.
• W2109765271 sameAs 2109765271 @default.
• W2109765271 citedByCount "35" @default.
• W2109765271 countsByYear W21097652712013 @default.
• W2109765271 countsByYear W21097652712014 @default.
• W2109765271 countsByYear W21097652712015 @default.
• W2109765271 countsByYear W21097652712016 @default.
• W2109765271 countsByYear W21097652712017 @default.
• W2109765271 countsByYear W21097652712019 @default.
• W2109765271 countsByYear W21097652712020 @default.
• W2109765271 countsByYear W21097652712021 @default.
• W2109765271 countsByYear W21097652712022 @default.
• W2109765271 crossrefType "journal-article" @default.
• W2109765271 hasAuthorship W2109765271A5015410806 @default.
• W2109765271 hasAuthorship W2109765271A5018970596 @default.
• W2109765271 hasAuthorship W2109765271A5045786709 @default.
• W2109765271 hasAuthorship W2109765271A5066347342 @default.
• W2109765271 hasAuthorship W2109765271A5067935460 @default.
• W2109765271 hasAuthorship W2109765271A5072669719 @default.
• W2109765271 hasAuthorship W2109765271A5080661141 @default.
• W2109765271 hasBestOaLocation W21097652711 @default.
• W2109765271 hasConcept C104317684 @default.
• W2109765271 hasConcept C126322002 @default.
• W2109765271 hasConcept C127561419 @default.
• W2109765271 hasConcept C134018914 @default.
• W2109765271 hasConcept C150194340 @default.
• W2109765271 hasConcept C151955695 @default.
• W2109765271 hasConcept C162317418 @default.
• W2109765271 hasConcept C164027704 @default.
• W2109765271 hasConcept C16930146 @default.
• W2109765271 hasConcept C171089720 @default.
• W2109765271 hasConcept C186738567 @default.
• W2109765271 hasConcept C203014093 @default.
• W2109765271 hasConcept C2776914184 @default.
• W2109765271 hasConcept C2778382381 @default.
• W2109765271 hasConcept C2779679481 @default.
• W2109765271 hasConcept C2780675426 @default.
• W2109765271 hasConcept C2780745355 @default.
• W2109765271 hasConcept C502942594 @default.
• W2109765271 hasConcept C54355233 @default.
• W2109765271 hasConcept C71924100 @default.
• W2109765271 hasConcept C86803240 @default.
• W2109765271 hasConceptScore W2109765271C104317684 @default.
• W2109765271 hasConceptScore W2109765271C126322002 @default.
• W2109765271 hasConceptScore W2109765271C127561419 @default.
• W2109765271 hasConceptScore W2109765271C134018914 @default.
• W2109765271 hasConceptScore W2109765271C150194340 @default.

• next