FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109767524> ?p ?o ?g. }

• W2109767524 endingPage "1121" @default.
• W2109767524 startingPage "1107" @default.
• W2109767524 abstract "Interactions of Staphylococcus aureus (S. aureus) and platelets play an important role in the pathogenesis of intravascular infections such as infective endocarditis (IE). A typical feature of S. aureus is the ability to generate thrombin activity through the secretion of two prothrombin activating molecules, staphylocoagulase and von Willebrand factor-binding protein (vWbp), which bind to human prothrombin to form the enzymatically active staphylothrombin complex. The role of staphylothrombin in the interaction between S. aureus and platelets has not yet been studied. We found that in contrast with thrombin, staphylothrombin did not directly activate human platelets. However, the staphylothrombin-mediated conversion of fibrinogen to fibrin initiated platelet aggregation and secondary activation and facilitated S. aureus-platelet interactions. Both the genetic absence of staphylocoagulase and vWbp and pharmacological inhibition of staphylothrombin increased the lag time to aggregation, and reduced platelet trapping by S. aureus in high shear stress conditions. The combined inhibition of staphylothrombin and immunoglobulin binding to platelets completely abolished the ability of S. aureus to aggregate platelets in vitro. In conclusion, although staphylothrombin did not directly activate platelets, the formation of a fibrin scaffold facilitated bacteria-platelet interaction, and the inhibition of staphylothrombin resulted in a reduced activation of platelets by S. aureus." @default.
• W2109767524 created "2016-06-24" @default.
• W2109767524 creator A5006329944 @default.
• W2109767524 creator A5025928709 @default.
• W2109767524 creator A5037293929 @default.
• W2109767524 creator A5053368690 @default.
• W2109767524 creator A5057802451 @default.
• W2109767524 creator A5073545087 @default.
• W2109767524 creator A5074198048 @default.
• W2109767524 creator A5083683183 @default.
• W2109767524 date "2012-01-01" @default.
• W2109767524 modified "2023-10-16" @default.
• W2109767524 title "Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation" @default.
• W2109767524 cites W1523327750 @default.
• W2109767524 cites W1578542647 @default.
• W2109767524 cites W1777116722 @default.
• W2109767524 cites W1811402656 @default.
• W2109767524 cites W1982474751 @default.
• W2109767524 cites W1984010753 @default.
• W2109767524 cites W1986517054 @default.
• W2109767524 cites W1988032045 @default.
• W2109767524 cites W1991532243 @default.
• W2109767524 cites W1991881504 @default.
• W2109767524 cites W1994860164 @default.
• W2109767524 cites W2009108165 @default.
• W2109767524 cites W2017950489 @default.
• W2109767524 cites W2030490295 @default.
• W2109767524 cites W2038993690 @default.
• W2109767524 cites W2047572709 @default.
• W2109767524 cites W2052492512 @default.
• W2109767524 cites W2060534700 @default.
• W2109767524 cites W2062568510 @default.
• W2109767524 cites W2065085815 @default.
• W2109767524 cites W2068041880 @default.
• W2109767524 cites W2072645998 @default.
• W2109767524 cites W2089957746 @default.
• W2109767524 cites W2092471071 @default.
• W2109767524 cites W2097316118 @default.
• W2109767524 cites W2103350224 @default.
• W2109767524 cites W2108709703 @default.
• W2109767524 cites W2116348263 @default.
• W2109767524 cites W2119370402 @default.
• W2109767524 cites W2120480555 @default.
• W2109767524 cites W2124254554 @default.
• W2109767524 cites W2126420325 @default.
• W2109767524 cites W2134444615 @default.
• W2109767524 cites W2146095795 @default.
• W2109767524 cites W2153289602 @default.
• W2109767524 cites W2161576398 @default.
• W2109767524 cites W2163554283 @default.
• W2109767524 cites W2166597983 @default.
• W2109767524 cites W2415342998 @default.
• W2109767524 cites W4235520347 @default.
• W2109767524 doi "https://doi.org/10.1160/th11-12-0891" @default.
• W2109767524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22437005" @default.
• W2109767524 hasPublicationYear "2012" @default.
• W2109767524 type Work @default.
• W2109767524 sameAs 2109767524 @default.
• W2109767524 citedByCount "56" @default.
• W2109767524 countsByYear W21097675242013 @default.
• W2109767524 countsByYear W21097675242014 @default.
• W2109767524 countsByYear W21097675242015 @default.
• W2109767524 countsByYear W21097675242016 @default.
• W2109767524 countsByYear W21097675242017 @default.
• W2109767524 countsByYear W21097675242018 @default.
• W2109767524 countsByYear W21097675242019 @default.
• W2109767524 countsByYear W21097675242020 @default.
• W2109767524 countsByYear W21097675242021 @default.
• W2109767524 countsByYear W21097675242022 @default.
• W2109767524 countsByYear W21097675242023 @default.
• W2109767524 crossrefType "journal-article" @default.
• W2109767524 hasAuthorship W2109767524A5006329944 @default.
• W2109767524 hasAuthorship W2109767524A5025928709 @default.
• W2109767524 hasAuthorship W2109767524A5037293929 @default.
• W2109767524 hasAuthorship W2109767524A5053368690 @default.
• W2109767524 hasAuthorship W2109767524A5057802451 @default.
• W2109767524 hasAuthorship W2109767524A5073545087 @default.
• W2109767524 hasAuthorship W2109767524A5074198048 @default.
• W2109767524 hasAuthorship W2109767524A5083683183 @default.
• W2109767524 hasConcept C185592680 @default.
• W2109767524 hasConcept C203014093 @default.
• W2109767524 hasConcept C2777292125 @default.
• W2109767524 hasConcept C2779036427 @default.
• W2109767524 hasConcept C2779489039 @default.
• W2109767524 hasConcept C3018697912 @default.
• W2109767524 hasConcept C523546767 @default.
• W2109767524 hasConcept C54173615 @default.
• W2109767524 hasConcept C54355233 @default.
• W2109767524 hasConcept C55493867 @default.
• W2109767524 hasConcept C86803240 @default.
• W2109767524 hasConcept C89423630 @default.
• W2109767524 hasConcept C89560881 @default.
• W2109767524 hasConceptScore W2109767524C185592680 @default.
• W2109767524 hasConceptScore W2109767524C203014093 @default.
• W2109767524 hasConceptScore W2109767524C2777292125 @default.
• W2109767524 hasConceptScore W2109767524C2779036427 @default.
• W2109767524 hasConceptScore W2109767524C2779489039 @default.
• W2109767524 hasConceptScore W2109767524C3018697912 @default.

• next