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- W2109776712 abstract "Intrathyroid epithelial tumour (ITET)/carcinoma showing thymus-like differentiation (CASTLE) is a rare malignant tumour, which is thought to originate from ectopic thymic tissue in the thyroid. The differential diagnosis between ITET/ CASTLE and squamous cell carcinoma (SCC) or undifferentiated carcinoma with squamoid component (UC-SCC) is very important, because ITET/CASTLE shows a far better prognosis than SCC or UC-SCC. In this study, we investigated the usefulness of S100A9, a marker of SCC and squamous cell epithelia, for diagnosis of ITET/CASTLE.We immunohistochemically investigated S100A9 expression in 23 ITET/CASTLEs, 26 SCCs, and 19 UC-SCCs, as well as eight thymomas and 12 normal thymic tissues.All thymomas and thymic tissues showed a small number of S100A9-expressing cells in a scattered pattern in accordance with Hassall corpuscles. Twenty-one of 23 ITET/ CASTLEs showed the same pattern as thymomas or thymic tissues, while 14 SCCs and 15 UC-SCCs showed diffuse and laminated positivity of S100A9. The positive predictive value and specificity of S100A9 for diagnosis of ITET/CASTLE was 91.3 and 93.9%, respectively, and sensitivity was 75.0%.These findings suggest that S100A9 is a useful marker for discriminating ITET/CASTLE from SCC or UC-SCC." @default.
- W2109776712 created "2016-06-24" @default.
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- W2109776712 date "2006-12-01" @default.
- W2109776712 modified "2023-09-24" @default.
- W2109776712 title "Usefulness of S100A9 for diagnosis of intrathyroid epithelial thymoma (ITET)/carcinoma showing thymus-like differentiation (CASTLE)" @default.
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- W2109776712 doi "https://doi.org/10.1080/00313020601024086" @default.
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