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• W2109778883 endingPage "1429" @default.
• W2109778883 startingPage "1423" @default.
• W2109778883 abstract "Conjugated linoleic acid (CLA) is a group of linoleic acid derivatives that has been implicated in animal studies to reduce a number of components of mammary tumorigenesis. Previously, we showed that CLA could alter the latency and metastasis of the highly metastatic transplantable line 4526 mouse mammary tumor. Several possible mechanisms have been proposed for the actions of CLA, but here we assessed how CLA may act to alter the expression and activity of matrix-modifying proteins within tumors from line 4526. In vitro, highly metastatic mouse mammary tumor cells had significantly decreased invasiveness after treatment with CLA, an indication that matrix-modifying proteins may have been altered. Using these same highly metastatic cells, primary tumors were grown in mice of separate groups fed 0, 0.1, 0.5, and 1% CLA (wt:wt) and evaluated for their levels and activities of matrix-modifying enzymes, enzyme inhibitors, and enzyme activators. The addition of CLA to the diet increased steady-state levels of messenger RNA (mRNA) of the matrix metalloproteinases (MMP) -2 and -9 in primary tumors removed from mice. However, western analysis revealed that although relative levels of the proform of MMP-9 were consistent with the mRNA observations, MMP-2 proform levels were actually decreased by dietary CLA. The activity of MMP-2 was barely detectable, but gelatin zymography and an in vitro activity assay showed that MMP-9 activity was significantly decreased by CLA. The steady-state mRNA and protein levels of tissue inhibitors of metalloproteinase-1 (TIMP-1) and TIMP-2, natural inhibitors of MMP, were increased at higher dietary CLA levels relative to low or no CLA. Suppression of MMP activity, therefore, may be 1 pathway through which CLA reduces tumor invasion and spread." @default.
• W2109778883 created "2016-06-24" @default.
• W2109778883 creator A5040148362 @default.
• W2109778883 creator A5062355226 @default.
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• W2109778883 date "2007-06-01" @default.
• W2109778883 modified "2023-10-02" @default.
• W2109778883 title "Conjugated Linoleic Acid Alters Matrix Metalloproteinases of Metastatic Mouse Mammary Tumor Cells ," @default.
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• W2109778883 doi "https://doi.org/10.1093/jn/137.6.1423" @default.
• W2109778883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17513401" @default.
• W2109778883 hasPublicationYear "2007" @default.
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