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- W2109780251 abstract "The artificial sweetener aspartame (Nutra Sweet) is hydrolyzed in the gut as phenylalanine (PA), a large neutral amino acid (LNAA). LNAAs compete with levodopa for uptake into the brain. To determine the effect of aspartame on levodopa-treated Parkinson9s disease (PD) patients, we studied 18 PD patients with protein-sensitive motor fluctuations by administering in a double-blind and single-crossover design, on alternate days, aspartame (600 or 1,200 mg) and placebo. Every hour, we performed a motor examination and drew blood to estimate plasma LNAA, PA, and levodopa levels. Six-hundred mg of aspartame had no effect on plasma PA or motor status. Although 1,200 mg of aspartame significantly increased plasma PA, motor performance did not deteriorate. Aspartame consumption in amounts well in excess of what would be consumed by heavy users of aspartame-sweetened products has no adverse effect on PD patients." @default.
- W2109780251 created "2016-06-24" @default.
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- W2109780251 date "1993-03-01" @default.
- W2109780251 modified "2023-09-25" @default.
- W2109780251 title "Aspartame use in Parkinson's disease" @default.
- W2109780251 doi "https://doi.org/10.1212/wnl.43.3_part_1.611" @default.
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