Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109789619> ?p ?o ?g. }
- W2109789619 endingPage "715" @default.
- W2109789619 startingPage "705" @default.
- W2109789619 abstract "Visfatin is a novel multifunctional adipocytokine with inflammatory properties. Although a link between visfatin and atherosclerosis has recently been suggested, its actions in the development of atherosclerosis remain unknown. Therefore, we investigated a potential role and underlying mechanism(s) of visfatin in monocytes/macrophages differentiation, a critical early step in atherogenesis, using phorbol-12-myristate-13-acetate (PMA)-stimulated THP-1 cell models. The co-incubation of PMA with visfatin-induced CD36 expression with a concomitant increase in the phagocytosis of latex beads compared with PMA alone treatment. Moreover, visfatin markedly increased interleukin (IL)-1β secretion by enhancing IL-1β mRNA stability in a short-term incubation. Visfatin also significantly elevated the secretion of IL-6 as well as IL-1β in a longer incubation period, which was partially suppressed by nuclear factor-κB (NF-κB) inhibitor, BAY11-7082, and c-Jun-N-terminal kinase (JNK) inhibitor, SP600125. Furthermore, silencing IL-1β successfully blocked IL-6 secretion, CD36 expression, and NF-κB activation in response to visfatin. Collectively, these results suggest that visfatin enhances the IL-1β-dependent induction of IL-6 and CD36 via distinct signaling pathways mediated by JNK and NF-κB, respectively, and consequently, leading to the acceleration of monocytes/macrophages differentiation." @default.
- W2109789619 created "2016-06-24" @default.
- W2109789619 creator A5011458812 @default.
- W2109789619 creator A5047093198 @default.
- W2109789619 creator A5075083918 @default.
- W2109789619 date "2014-04-01" @default.
- W2109789619 modified "2023-10-18" @default.
- W2109789619 title "Visfatin contributes to the differentiation of monocytes into macrophages through the differential regulation of inflammatory cytokines in THP-1 cells" @default.
- W2109789619 cites W1497455654 @default.
- W2109789619 cites W1926532709 @default.
- W2109789619 cites W1932093217 @default.
- W2109789619 cites W1964939500 @default.
- W2109789619 cites W1966056959 @default.
- W2109789619 cites W1968994034 @default.
- W2109789619 cites W1969867597 @default.
- W2109789619 cites W1972326883 @default.
- W2109789619 cites W1972348350 @default.
- W2109789619 cites W1978954324 @default.
- W2109789619 cites W1984699310 @default.
- W2109789619 cites W1986627716 @default.
- W2109789619 cites W1988123856 @default.
- W2109789619 cites W1996926257 @default.
- W2109789619 cites W2010245357 @default.
- W2109789619 cites W2027033448 @default.
- W2109789619 cites W2029485390 @default.
- W2109789619 cites W2039388307 @default.
- W2109789619 cites W2039870165 @default.
- W2109789619 cites W2052032972 @default.
- W2109789619 cites W2056364365 @default.
- W2109789619 cites W2061437853 @default.
- W2109789619 cites W2064711537 @default.
- W2109789619 cites W2066963386 @default.
- W2109789619 cites W2070664389 @default.
- W2109789619 cites W2077745556 @default.
- W2109789619 cites W2080555890 @default.
- W2109789619 cites W2092523176 @default.
- W2109789619 cites W2092855663 @default.
- W2109789619 cites W2093979977 @default.
- W2109789619 cites W2098419930 @default.
- W2109789619 cites W2100748836 @default.
- W2109789619 cites W2104052333 @default.
- W2109789619 cites W2122057254 @default.
- W2109789619 cites W2122990064 @default.
- W2109789619 cites W2124620986 @default.
- W2109789619 cites W2125909068 @default.
- W2109789619 cites W2135110328 @default.
- W2109789619 cites W2137500094 @default.
- W2109789619 cites W2149250436 @default.
- W2109789619 cites W2156628356 @default.
- W2109789619 cites W2162405407 @default.
- W2109789619 cites W2166457826 @default.
- W2109789619 cites W2169166528 @default.
- W2109789619 doi "https://doi.org/10.1016/j.cellsig.2013.12.010" @default.
- W2109789619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24378536" @default.
- W2109789619 hasPublicationYear "2014" @default.
- W2109789619 type Work @default.
- W2109789619 sameAs 2109789619 @default.
- W2109789619 citedByCount "33" @default.
- W2109789619 countsByYear W21097896192014 @default.
- W2109789619 countsByYear W21097896192015 @default.
- W2109789619 countsByYear W21097896192016 @default.
- W2109789619 countsByYear W21097896192017 @default.
- W2109789619 countsByYear W21097896192018 @default.
- W2109789619 countsByYear W21097896192019 @default.
- W2109789619 countsByYear W21097896192020 @default.
- W2109789619 countsByYear W21097896192021 @default.
- W2109789619 countsByYear W21097896192022 @default.
- W2109789619 countsByYear W21097896192023 @default.
- W2109789619 crossrefType "journal-article" @default.
- W2109789619 hasAuthorship W2109789619A5011458812 @default.
- W2109789619 hasAuthorship W2109789619A5047093198 @default.
- W2109789619 hasAuthorship W2109789619A5075083918 @default.
- W2109789619 hasConcept C11988809 @default.
- W2109789619 hasConcept C126322002 @default.
- W2109789619 hasConcept C134018914 @default.
- W2109789619 hasConcept C164027704 @default.
- W2109789619 hasConcept C170493617 @default.
- W2109789619 hasConcept C185592680 @default.
- W2109789619 hasConcept C195794163 @default.
- W2109789619 hasConcept C204258353 @default.
- W2109789619 hasConcept C2776914184 @default.
- W2109789619 hasConcept C2777730290 @default.
- W2109789619 hasConcept C2778690821 @default.
- W2109789619 hasConcept C2779828298 @default.
- W2109789619 hasConcept C2781184567 @default.
- W2109789619 hasConcept C49039625 @default.
- W2109789619 hasConcept C54355233 @default.
- W2109789619 hasConcept C62478195 @default.
- W2109789619 hasConcept C71924100 @default.
- W2109789619 hasConcept C74172505 @default.
- W2109789619 hasConcept C81885089 @default.
- W2109789619 hasConcept C86803240 @default.
- W2109789619 hasConcept C95444343 @default.
- W2109789619 hasConceptScore W2109789619C11988809 @default.
- W2109789619 hasConceptScore W2109789619C126322002 @default.
- W2109789619 hasConceptScore W2109789619C134018914 @default.
- W2109789619 hasConceptScore W2109789619C164027704 @default.
- W2109789619 hasConceptScore W2109789619C170493617 @default.