Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109790710> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2109790710 endingPage "398" @default.
- W2109790710 startingPage "392" @default.
- W2109790710 abstract "Retinoic acid (RA), a well-known inducer of differentiation, has been shown to regulate its own receptor gene expression in F9 teratocarcinoma cells. The homologous regulation of receptors by RA might be critical for RA-induced F9 cell differentiation. F9 cell lines from two different laboratories, named F9-1 and F9-2, were compared for retinoic acid receptor (RAR) and retinoid x receptor (RXR) gene expression in response to RA. The data show that both F9-1 and F9-2 cell lines are embryonal carcinoma cells, but of different phenotypes and different sensitivity to RA. In F9-1 cells, RA regulates all three RARs (α, β, and γ), two RXRs (α and γ), two activin receptors (ActR II and IIB), and tissue-specific plasminogen activator (t-PA) gene expression. In F9-2 cells RA regulates only the RARβ, RXRα, and t-PA genes. The induction of mRNA levels was much higher in F9-1 than in F9-2 cells. Different basal RARγ and RXRγ mRNA levels were also noted. In these two cell lines F9-2 cells expressed greater amounts of RARγ1, γ2, and γ3 mRNA isoforms, but lacked RXRγ mRNA compared with F9-1 cells. Since RARγ1 has been shown to exert an antagonistic effect on other types of RA receptors, the decreased sensitivity of F9-2 cells to RA might be due to its high level of RARγ1 and/or low level of RXRγ. This notion was in part supported by gel shift assay which demonstrated constitutive binding of RARγ to a RA responsive element (RARβE) in F9-2 cells. Further, the binding of nuclear protein to RARβE was increased upon RA treatment in F9-1 cells, but not in F9-2 cells. These differences in the regulation of RA receptors might determine the sensitivity of the two substrains of F9 cells to RA." @default.
- W2109790710 created "2016-06-24" @default.
- W2109790710 creator A5035522236 @default.
- W2109790710 creator A5036116332 @default.
- W2109790710 creator A5042731770 @default.
- W2109790710 date "1995-08-01" @default.
- W2109790710 modified "2023-09-26" @default.
- W2109790710 title "Different Response to Retinoic Acid of Two Teratocarcinoma Cell Lines" @default.
- W2109790710 doi "https://doi.org/10.1006/excr.1995.1244" @default.
- W2109790710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7543852" @default.
- W2109790710 hasPublicationYear "1995" @default.
- W2109790710 type Work @default.
- W2109790710 sameAs 2109790710 @default.
- W2109790710 citedByCount "10" @default.
- W2109790710 crossrefType "journal-article" @default.
- W2109790710 hasAuthorship W2109790710A5035522236 @default.
- W2109790710 hasAuthorship W2109790710A5036116332 @default.
- W2109790710 hasAuthorship W2109790710A5042731770 @default.
- W2109790710 hasConcept C104317684 @default.
- W2109790710 hasConcept C120197328 @default.
- W2109790710 hasConcept C128821507 @default.
- W2109790710 hasConcept C148738053 @default.
- W2109790710 hasConcept C153911025 @default.
- W2109790710 hasConcept C170493617 @default.
- W2109790710 hasConcept C2775954498 @default.
- W2109790710 hasConcept C2781121885 @default.
- W2109790710 hasConcept C2908788973 @default.
- W2109790710 hasConcept C53345823 @default.
- W2109790710 hasConcept C54355233 @default.
- W2109790710 hasConcept C55493867 @default.
- W2109790710 hasConcept C63932345 @default.
- W2109790710 hasConcept C81885089 @default.
- W2109790710 hasConcept C86339819 @default.
- W2109790710 hasConcept C86803240 @default.
- W2109790710 hasConceptScore W2109790710C104317684 @default.
- W2109790710 hasConceptScore W2109790710C120197328 @default.
- W2109790710 hasConceptScore W2109790710C128821507 @default.
- W2109790710 hasConceptScore W2109790710C148738053 @default.
- W2109790710 hasConceptScore W2109790710C153911025 @default.
- W2109790710 hasConceptScore W2109790710C170493617 @default.
- W2109790710 hasConceptScore W2109790710C2775954498 @default.
- W2109790710 hasConceptScore W2109790710C2781121885 @default.
- W2109790710 hasConceptScore W2109790710C2908788973 @default.
- W2109790710 hasConceptScore W2109790710C53345823 @default.
- W2109790710 hasConceptScore W2109790710C54355233 @default.
- W2109790710 hasConceptScore W2109790710C55493867 @default.
- W2109790710 hasConceptScore W2109790710C63932345 @default.
- W2109790710 hasConceptScore W2109790710C81885089 @default.
- W2109790710 hasConceptScore W2109790710C86339819 @default.
- W2109790710 hasConceptScore W2109790710C86803240 @default.
- W2109790710 hasIssue "2" @default.
- W2109790710 hasLocation W21097907101 @default.
- W2109790710 hasLocation W21097907102 @default.
- W2109790710 hasOpenAccess W2109790710 @default.
- W2109790710 hasPrimaryLocation W21097907101 @default.
- W2109790710 hasRelatedWork W1983568395 @default.
- W2109790710 hasRelatedWork W1996993064 @default.
- W2109790710 hasRelatedWork W2013229118 @default.
- W2109790710 hasRelatedWork W2037973801 @default.
- W2109790710 hasRelatedWork W2057181609 @default.
- W2109790710 hasRelatedWork W2110754977 @default.
- W2109790710 hasRelatedWork W2120879030 @default.
- W2109790710 hasRelatedWork W2157375354 @default.
- W2109790710 hasRelatedWork W2417390023 @default.
- W2109790710 hasRelatedWork W338309488 @default.
- W2109790710 hasVolume "219" @default.
- W2109790710 isParatext "false" @default.
- W2109790710 isRetracted "false" @default.
- W2109790710 magId "2109790710" @default.
- W2109790710 workType "article" @default.