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- W2109794895 abstract "Resistance is a constant challenge for anti-infective drug development. Since they kill sensitive organisms, anti-infective agents are bound to exert an evolutionary pressure toward the emergence and spread of resistance mechanisms, if such resistance can arise by stochastic mutation events. New classes of medicines under development must be designed or selected to stay ahead in this vicious circle of resistance control. This involves both circumventing existing resistance mechanisms and selecting molecules which are resilient against the development and spread of resistance. Cell-based screening methods have led to a renaissance of new classes of anti-malarial medicines, offering us the potential to select and modify molecules based on their resistance potential. To that end, a standardized in vitro methodology to assess quantitatively these characteristics in Plasmodium falciparum during the early phases of the drug development process has been developed and is presented here. It allows the identification of anti-malarial compounds with overt resistance risks and the prioritization of the most robust ones. The integration of this strategy in later stages of development, registration, and deployment is also discussed." @default.
- W2109794895 created "2016-06-24" @default.
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- W2109794895 date "2012-08-22" @default.
- W2109794895 modified "2023-10-15" @default.
- W2109794895 title "A framework for assessing the risk of resistance for anti-malarials in development" @default.
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- W2109794895 cites W1974720373 @default.
- W2109794895 cites W1976176203 @default.
- W2109794895 cites W1976566329 @default.
- W2109794895 cites W1981089872 @default.
- W2109794895 cites W1981734114 @default.
- W2109794895 cites W1989687467 @default.
- W2109794895 cites W1990805655 @default.
- W2109794895 cites W2009146673 @default.
- W2109794895 cites W2010485888 @default.
- W2109794895 cites W2010497810 @default.
- W2109794895 cites W2014275882 @default.
- W2109794895 cites W2014429457 @default.
- W2109794895 cites W2016154554 @default.
- W2109794895 cites W2018952692 @default.
- W2109794895 cites W2023376441 @default.
- W2109794895 cites W2026791163 @default.
- W2109794895 cites W2030481162 @default.
- W2109794895 cites W2033518384 @default.
- W2109794895 cites W2035758606 @default.
- W2109794895 cites W2040713555 @default.
- W2109794895 cites W2047009134 @default.
- W2109794895 cites W2051220419 @default.
- W2109794895 cites W2056736082 @default.
- W2109794895 cites W2057111823 @default.
- W2109794895 cites W2067475849 @default.
- W2109794895 cites W2071271960 @default.
- W2109794895 cites W2074654911 @default.
- W2109794895 cites W2079127050 @default.
- W2109794895 cites W2083522771 @default.
- W2109794895 cites W2086386648 @default.
- W2109794895 cites W2087512923 @default.
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- W2109794895 cites W2097116672 @default.
- W2109794895 cites W2100013190 @default.
- W2109794895 cites W2101036752 @default.
- W2109794895 cites W2104244554 @default.
- W2109794895 cites W2107905625 @default.
- W2109794895 cites W2108169668 @default.
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- W2109794895 cites W2127973996 @default.
- W2109794895 cites W2128597754 @default.
- W2109794895 cites W2130028379 @default.
- W2109794895 cites W2132923209 @default.
- W2109794895 cites W2135697415 @default.
- W2109794895 cites W2135926190 @default.
- W2109794895 cites W2137764200 @default.
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- W2109794895 cites W2141429378 @default.
- W2109794895 cites W2143552714 @default.
- W2109794895 cites W2145537179 @default.
- W2109794895 cites W2148926813 @default.
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- W2109794895 doi "https://doi.org/10.1186/1475-2875-11-292" @default.
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