FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109795536> ?p ?o ?g. }

• W2109795536 endingPage "F490" @default.
• W2109795536 startingPage "F480" @default.
• W2109795536 abstract "Meprins are membrane-bound and secreted metalloproteinases consisting of α- and/or β-subunits that are highly expressed in mouse kidney proximal tubules. Previous studies have implied that the meprin α/β-isoform is deleterious when renal tissue is subjected to ischemia-reperfusion (I/R). To delineate the roles of the meprin isoforms in renal disease, we subjected mice deficient in meprin-β (KO) and their wild-type (WT) counterparts to I/R. WT mice were markedly more susceptible to renal injury after I/R than the meprin-β KO mice as determined by blood urea nitrogen levels. Urinary levels of inflammatory cytokines IL-6 and KC (CXCL1) were significantly higher in WT compared with meprin-β KO mice by 6 h post-I/R. At 96 h postischemia, kidney mRNA expression levels for tumor necrosis factor-α, transforming growth factor-β, inducible nitric oxide synthase, and heat shock protein-27 were significantly higher in the WT than meprin-β KO mice. For WT mice subjected to I/R, there was a rapid (3 h) redistribution of meprin β-subunits in cells in S3 segments of proximal tubules, followed by shedding of apical cell membrane and detachment of cells. These studies indicate that meprin-β is important in the pathogenesis of renal injury following I/R and that the redistribution of active meprin-α/β is a major contributor to renal injury and subsequent inflammation." @default.
• W2109795536 created "2016-06-24" @default.
• W2109795536 creator A5022162319 @default.
• W2109795536 creator A5051664257 @default.
• W2109795536 creator A5053780153 @default.
• W2109795536 creator A5061050826 @default.
• W2109795536 creator A5090568840 @default.
• W2109795536 creator A5069450508 @default.
• W2109795536 date "2008-03-01" @default.
• W2109795536 modified "2023-09-25" @default.
• W2109795536 title "Targeted disruption of the meprin metalloproteinase β gene protects against renal ischemia-reperfusion injury in mice" @default.
• W2109795536 cites W1498169126 @default.
• W2109795536 cites W1501974073 @default.
• W2109795536 cites W1508079805 @default.
• W2109795536 cites W1588064010 @default.
• W2109795536 cites W1850950958 @default.
• W2109795536 cites W1969443848 @default.
• W2109795536 cites W1974011244 @default.
• W2109795536 cites W1974269325 @default.
• W2109795536 cites W1975380783 @default.
• W2109795536 cites W1981033024 @default.
• W2109795536 cites W1982516317 @default.
• W2109795536 cites W1983533707 @default.
• W2109795536 cites W1984540717 @default.
• W2109795536 cites W1985491668 @default.
• W2109795536 cites W2002765675 @default.
• W2109795536 cites W2007058758 @default.
• W2109795536 cites W2007240114 @default.
• W2109795536 cites W2007929302 @default.
• W2109795536 cites W2014447726 @default.
• W2109795536 cites W2024154210 @default.
• W2109795536 cites W2030060549 @default.
• W2109795536 cites W2031264231 @default.
• W2109795536 cites W2035568993 @default.
• W2109795536 cites W2043209085 @default.
• W2109795536 cites W2050164482 @default.
• W2109795536 cites W2052696386 @default.
• W2109795536 cites W2053433479 @default.
• W2109795536 cites W2057267774 @default.
• W2109795536 cites W2061474112 @default.
• W2109795536 cites W2078661860 @default.
• W2109795536 cites W2089337540 @default.
• W2109795536 cites W2090407175 @default.
• W2109795536 cites W2095369742 @default.
• W2109795536 cites W2095582000 @default.
• W2109795536 cites W2100967062 @default.
• W2109795536 cites W2110871281 @default.
• W2109795536 cites W2122918206 @default.
• W2109795536 cites W2128704535 @default.
• W2109795536 cites W2130669420 @default.
• W2109795536 cites W2142454070 @default.
• W2109795536 cites W2145297164 @default.
• W2109795536 cites W2152331716 @default.
• W2109795536 cites W2157917051 @default.
• W2109795536 cites W2171344771 @default.
• W2109795536 cites W2301266272 @default.
• W2109795536 cites W23360501 @default.
• W2109795536 cites W2410744491 @default.
• W2109795536 cites W2413896845 @default.
• W2109795536 cites W4230046859 @default.
• W2109795536 doi "https://doi.org/10.1152/ajprenal.00214.2007" @default.
• W2109795536 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18172000" @default.
• W2109795536 hasPublicationYear "2008" @default.
• W2109795536 type Work @default.
• W2109795536 sameAs 2109795536 @default.
• W2109795536 citedByCount "50" @default.
• W2109795536 countsByYear W21097955362012 @default.
• W2109795536 countsByYear W21097955362013 @default.
• W2109795536 countsByYear W21097955362014 @default.
• W2109795536 countsByYear W21097955362015 @default.
• W2109795536 countsByYear W21097955362016 @default.
• W2109795536 countsByYear W21097955362017 @default.
• W2109795536 countsByYear W21097955362018 @default.
• W2109795536 countsByYear W21097955362019 @default.
• W2109795536 countsByYear W21097955362020 @default.
• W2109795536 countsByYear W21097955362021 @default.
• W2109795536 countsByYear W21097955362022 @default.
• W2109795536 countsByYear W21097955362023 @default.
• W2109795536 crossrefType "journal-article" @default.
• W2109795536 hasAuthorship W2109795536A5022162319 @default.
• W2109795536 hasAuthorship W2109795536A5051664257 @default.
• W2109795536 hasAuthorship W2109795536A5053780153 @default.
• W2109795536 hasAuthorship W2109795536A5061050826 @default.
• W2109795536 hasAuthorship W2109795536A5069450508 @default.
• W2109795536 hasAuthorship W2109795536A5090568840 @default.
• W2109795536 hasConcept C109523444 @default.
• W2109795536 hasConcept C126322002 @default.
• W2109795536 hasConcept C13373296 @default.
• W2109795536 hasConcept C134018914 @default.
• W2109795536 hasConcept C153911025 @default.
• W2109795536 hasConcept C185592680 @default.
• W2109795536 hasConcept C2776914184 @default.
• W2109795536 hasConcept C2780091579 @default.
• W2109795536 hasConcept C55728118 @default.
• W2109795536 hasConcept C71924100 @default.
• W2109795536 hasConcept C86803240 @default.
• W2109795536 hasConcept C96525457 @default.
• W2109795536 hasConceptScore W2109795536C109523444 @default.

• next