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• W2109802392 abstract "Abstract Background In vivo proton magnetic resonance spectroscopy ( 1 H-MRS) studies of HIV-infected humans have demonstrated significant metabolic abnormalities that vary by brain region, but the causes are poorly understood. Metabolic changes in the frontal cortex, basal ganglia and white matter in 18 SIV-infected macaques were investigated using MRS during the first month of infection. Results Changes in the N-acetylaspartate (NAA), choline (Cho), myo -inositol (MI), creatine (Cr) and glutamine/glutamate (Glx) resonances were quantified both in absolute terms and relative to the creatine resonance. Most abnormalities were observed at the time of peak viremia, 2 weeks post infection (wpi). At that time point, significant decreases in NAA and NAA/Cr, reflecting neuronal injury, were observed only in the frontal cortex. Cr was significantly elevated only in the white matter. Changes in Cho and Cho/Cr were similar across the brain regions, increasing at 2 wpi, and falling below baseline levels at 4 wpi. MI and MI/Cr levels were increased across all brain regions. Conclusion These data best support the hypothesis that different brain regions have variable intrinsic vulnerabilities to neuronal injury caused by the AIDS virus." @default.
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• W2109802392 date "2009-06-22" @default.
• W2109802392 modified "2023-10-11" @default.
• W2109802392 title "In vivo proton magnetic resonance spectroscopy reveals region specific metabolic responses to SIV infection in the macaque brain" @default.
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• W2109802392 doi "https://doi.org/10.1186/1471-2202-10-63" @default.
• W2109802392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2711091" @default.
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