FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109807813> ?p ?o ?g. }

• W2109807813 endingPage "1613" @default.
• W2109807813 startingPage "1596" @default.
• W2109807813 abstract "Abstract Quantitative peptidomics was used to compare levels of peptides in wild type (WT) and Cpe fat/fat mice, which lack carboxypeptidase E (CPE) activity because of a point mutation. Six different brain regions were analyzed: amygdala, hippocampus, hypothalamus, prefrontal cortex, striatum, and thalamus. Altogether, 111 neuropeptides or other peptides derived from secretory pathway proteins were identified in WT mouse brain extracts by tandem mass spectrometry, and another 47 peptides were tentatively identified based on mass and other criteria. Most secretory pathway peptides were much lower in Cpe fat/fat mouse brain, relative to WT mouse brain, indicating that CPE plays a major role in their biosynthesis. Other peptides were only partially reduced in the Cpe fat/fat mice, indicating that another enzyme (presumably carboxypeptidase D) contributes to their biosynthesis. Approximately 10% of the secretory pathway peptides were present in the Cpe fat/fat mouse brain at levels similar to those in WT mouse brain. Many peptides were greatly elevated in the Cpe fat/fat mice; these peptide processing intermediates with C‐terminal Lys and/or Arg were generally not detectable in WT mice. Taken together, these results indicate that CPE contributes, either directly or indirectly, to the production of the majority of neuropeptides." @default.
• W2109807813 created "2016-06-24" @default.
• W2109807813 creator A5005047234 @default.
• W2109807813 creator A5006651636 @default.
• W2109807813 creator A5009866475 @default.
• W2109807813 creator A5020423575 @default.
• W2109807813 creator A5023103090 @default.
• W2109807813 creator A5082020452 @default.
• W2109807813 date "2008-11-24" @default.
• W2109807813 modified "2023-10-10" @default.
• W2109807813 title "Peptidomics of <i>Cpe</i>^{<i>fat/fat</i>} mouse brain regions: implications for neuropeptide processing" @default.
• W2109807813 cites W1523129878 @default.
• W2109807813 cites W1563942524 @default.
• W2109807813 cites W1572212276 @default.
• W2109807813 cites W1816353495 @default.
• W2109807813 cites W1885047062 @default.
• W2109807813 cites W1963483442 @default.
• W2109807813 cites W1966470012 @default.
• W2109807813 cites W1966799185 @default.
• W2109807813 cites W1966892789 @default.
• W2109807813 cites W1967639182 @default.
• W2109807813 cites W1970953442 @default.
• W2109807813 cites W1971039109 @default.
• W2109807813 cites W1974849210 @default.
• W2109807813 cites W1976086374 @default.
• W2109807813 cites W1979693854 @default.
• W2109807813 cites W1982514291 @default.
• W2109807813 cites W1982586023 @default.
• W2109807813 cites W1988176512 @default.
• W2109807813 cites W1990203312 @default.
• W2109807813 cites W1990208041 @default.
• W2109807813 cites W1991263759 @default.
• W2109807813 cites W1991273592 @default.
• W2109807813 cites W1996201041 @default.
• W2109807813 cites W1996238403 @default.
• W2109807813 cites W1996470773 @default.
• W2109807813 cites W1997895427 @default.
• W2109807813 cites W1999568120 @default.
• W2109807813 cites W2003789671 @default.
• W2109807813 cites W2003805044 @default.
• W2109807813 cites W2003822998 @default.
• W2109807813 cites W2003914197 @default.
• W2109807813 cites W2005951646 @default.
• W2109807813 cites W2008580181 @default.
• W2109807813 cites W2011856428 @default.
• W2109807813 cites W2012126404 @default.
• W2109807813 cites W2017750045 @default.
• W2109807813 cites W2023789513 @default.
• W2109807813 cites W2024322336 @default.
• W2109807813 cites W2033340247 @default.
• W2109807813 cites W2033947177 @default.
• W2109807813 cites W2036375633 @default.
• W2109807813 cites W2036412667 @default.
• W2109807813 cites W2038439787 @default.
• W2109807813 cites W2040035530 @default.
• W2109807813 cites W2040993569 @default.
• W2109807813 cites W2042165079 @default.
• W2109807813 cites W2048548162 @default.
• W2109807813 cites W2050912412 @default.
• W2109807813 cites W2055093639 @default.
• W2109807813 cites W2056868493 @default.
• W2109807813 cites W2058479383 @default.
• W2109807813 cites W2058936782 @default.
• W2109807813 cites W2068159672 @default.
• W2109807813 cites W2081180099 @default.
• W2109807813 cites W2082528610 @default.
• W2109807813 cites W2092367131 @default.
• W2109807813 cites W2093600045 @default.
• W2109807813 cites W2099115577 @default.
• W2109807813 cites W2116901594 @default.
• W2109807813 cites W2120032466 @default.
• W2109807813 cites W2124917755 @default.
• W2109807813 cites W2127709439 @default.
• W2109807813 cites W2130921855 @default.
• W2109807813 cites W2134660680 @default.
• W2109807813 cites W2144955458 @default.
• W2109807813 cites W2154821229 @default.
• W2109807813 cites W2156695091 @default.
• W2109807813 cites W2157397275 @default.
• W2109807813 cites W2158561816 @default.
• W2109807813 cites W2160266742 @default.
• W2109807813 cites W2161481831 @default.
• W2109807813 cites W2163791740 @default.
• W2109807813 cites W2171091522 @default.
• W2109807813 cites W2290801244 @default.
• W2109807813 cites W4244906151 @default.
• W2109807813 cites W4245162831 @default.
• W2109807813 cites W4246595341 @default.
• W2109807813 cites W4251859800 @default.
• W2109807813 doi "https://doi.org/10.1111/j.1471-4159.2008.05722.x" @default.
• W2109807813 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2663970" @default.
• W2109807813 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19014391" @default.
• W2109807813 hasPublicationYear "2008" @default.
• W2109807813 type Work @default.
• W2109807813 sameAs 2109807813 @default.
• W2109807813 citedByCount "82" @default.
• W2109807813 countsByYear W21098078132012 @default.
• W2109807813 countsByYear W21098078132013 @default.

• next