FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109832371> ?p ?o ?g. }

• W2109832371 endingPage "1954" @default.
• W2109832371 startingPage "1949" @default.
• W2109832371 abstract "ABSTRACT Artemether-lumefantrine (AL), dihydroartemisinin-piperaquine (DP), and amodiaquine-sulfadoxine-pyrimethamine (AQ-SP) offer excellent antimalarial efficacy but may select for parasite polymorphisms that decrease drug sensitivity. We evaluated the selection of known polymorphisms in genes encoding putative transporters ( pfcrt and pfmdr1 ) and SP targets ( pfdhfr and pfdhps ) in parasites that caused new infections within 42 days of therapy for uncomplicated falciparum malaria in Burkina Faso. In 559 children in 2006, 42-day genotype-uncorrected failures were seen in 31.2% with AL, 11.8% with AQ-SP, and 7.6% with DP. After prior AL therapy, selection of wild-type sequences was seen for K76T in pfcrt (72.7% mixed or mutant results pretreatment versus 52.1% in new infections; P = 0.008) and N86Y (36.0% versus 18.7%; P = 0.025) and Y184F (66.7% versus 45.8%; P = 0.009) in pfmdr1 . After prior AQ-SP therapy, selection of mutant sequences was seen for N51I (30.8% versus 61.5%; P = 0.05), C59R (28.2% versus 76.9%; P = 0.002), and S108N (30.8% versus 76.9%; P = 0.005) in pfdhfr . After prior DP therapy, selection was not seen for K76T (72.7% versus 77.8%; P = 0.96) in pfcrt or N86Y (36.0% versus 33.3%; P = 0.84), Y184F (66.7% versus 77.8%; P = 0.39), or D1246Y (9.3% versus 0%; P = 0.42) in pfmdr1 . In 378 additional treatments with DP in 2007, 42-day uncorrected failure was seen in 10.9%. After prior DP, selection was again not seen for K76T (66.7% mixed or mutant results versus 59.5%; P = 0.43) in pfcrt or N86Y (38.7% versus 40.5%; P = 0.85), Y184F (67.6% versus 73.0%; P = 0.54), or D1246Y (3.6% versus 8.1%; P = 0.50) in pfmdr1 . Despite its chemical similarity, piperaquine did not select for the same polymorphisms as chloroquine or AQ, suggesting different mechanisms of resistance." @default.
• W2109832371 created "2016-06-24" @default.
• W2109832371 creator A5018877466 @default.
• W2109832371 creator A5036228603 @default.
• W2109832371 creator A5037647381 @default.
• W2109832371 creator A5045141250 @default.
• W2109832371 creator A5054207126 @default.
• W2109832371 creator A5069406939 @default.
• W2109832371 creator A5071298806 @default.
• W2109832371 creator A5077631479 @default.
• W2109832371 date "2010-05-01" @default.
• W2109832371 modified "2023-10-18" @default.
• W2109832371 title "Selection of Known <i>Plasmodium falciparum</i> Resistance-Mediating Polymorphisms by Artemether-Lumefantrine and Amodiaquine- Sulfadoxine-Pyrimethamine but Not Dihydroartemisinin- Piperaquine in Burkina Faso" @default.
• W2109832371 cites W1483203554 @default.
• W2109832371 cites W1835840082 @default.
• W2109832371 cites W1950804392 @default.
• W2109832371 cites W1964931574 @default.
• W2109832371 cites W1970856471 @default.
• W2109832371 cites W1972177048 @default.
• W2109832371 cites W1972778967 @default.
• W2109832371 cites W1977603169 @default.
• W2109832371 cites W1982497887 @default.
• W2109832371 cites W1991442399 @default.
• W2109832371 cites W1994921720 @default.
• W2109832371 cites W1996098609 @default.
• W2109832371 cites W2005705112 @default.
• W2109832371 cites W2008166606 @default.
• W2109832371 cites W2023687237 @default.
• W2109832371 cites W2025054505 @default.
• W2109832371 cites W2029734218 @default.
• W2109832371 cites W2048834380 @default.
• W2109832371 cites W2052262611 @default.
• W2109832371 cites W2076029682 @default.
• W2109832371 cites W2101114302 @default.
• W2109832371 cites W2103132311 @default.
• W2109832371 cites W2104536143 @default.
• W2109832371 cites W2106346927 @default.
• W2109832371 cites W2109191053 @default.
• W2109832371 cites W2109688696 @default.
• W2109832371 cites W2110456860 @default.
• W2109832371 cites W2115398829 @default.
• W2109832371 cites W2120009689 @default.
• W2109832371 cites W2122967261 @default.
• W2109832371 cites W2123129595 @default.
• W2109832371 cites W2132923209 @default.
• W2109832371 cites W2136098427 @default.
• W2109832371 cites W2136308226 @default.
• W2109832371 cites W2137601868 @default.
• W2109832371 cites W2137636253 @default.
• W2109832371 cites W2141125668 @default.
• W2109832371 cites W2149109668 @default.
• W2109832371 cites W2150522686 @default.
• W2109832371 cites W2152672321 @default.
• W2109832371 cites W2152960683 @default.
• W2109832371 cites W2156469502 @default.
• W2109832371 cites W2159307889 @default.
• W2109832371 cites W2163765308 @default.
• W2109832371 cites W2165454717 @default.
• W2109832371 cites W2166357496 @default.
• W2109832371 cites W2301023468 @default.
• W2109832371 cites W2333050857 @default.
• W2109832371 cites W2396351265 @default.
• W2109832371 cites W4211099777 @default.
• W2109832371 doi "https://doi.org/10.1128/aac.01413-09" @default.
• W2109832371 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2863637" @default.
• W2109832371 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20231394" @default.
• W2109832371 hasPublicationYear "2010" @default.
• W2109832371 type Work @default.
• W2109832371 sameAs 2109832371 @default.
• W2109832371 citedByCount "88" @default.
• W2109832371 countsByYear W21098323712012 @default.
• W2109832371 countsByYear W21098323712013 @default.
• W2109832371 countsByYear W21098323712014 @default.
• W2109832371 countsByYear W21098323712015 @default.
• W2109832371 countsByYear W21098323712016 @default.
• W2109832371 countsByYear W21098323712017 @default.
• W2109832371 countsByYear W21098323712018 @default.
• W2109832371 countsByYear W21098323712019 @default.
• W2109832371 countsByYear W21098323712020 @default.
• W2109832371 countsByYear W21098323712021 @default.
• W2109832371 countsByYear W21098323712022 @default.
• W2109832371 countsByYear W21098323712023 @default.
• W2109832371 crossrefType "journal-article" @default.
• W2109832371 hasAuthorship W2109832371A5018877466 @default.
• W2109832371 hasAuthorship W2109832371A5036228603 @default.
• W2109832371 hasAuthorship W2109832371A5037647381 @default.
• W2109832371 hasAuthorship W2109832371A5045141250 @default.
• W2109832371 hasAuthorship W2109832371A5054207126 @default.
• W2109832371 hasAuthorship W2109832371A5069406939 @default.
• W2109832371 hasAuthorship W2109832371A5071298806 @default.
• W2109832371 hasAuthorship W2109832371A5077631479 @default.
• W2109832371 hasBestOaLocation W21098323712 @default.
• W2109832371 hasConcept C126322002 @default.
• W2109832371 hasConcept C159047783 @default.
• W2109832371 hasConcept C203014093 @default.
• W2109832371 hasConcept C2776120307 @default.
• W2109832371 hasConcept C2776992834 @default.
• W2109832371 hasConcept C2777035104 @default.

• next