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• W2109837218 abstract "Endothelium-derived hyperpolarizing factor (EDHF) plays an important role in the regulation of vascular microcirculatory tone. This study explores the role of estrogen in controlling EDHF-mediated vasodilation of uterine resistance arteries of the rat and also analyzes the contribution of endothelial cell (EC) Ca 2+ signaling to this process. A parallel study was also performed with mesenteric arteries to provide comparison with a nonreproductive vasculature. Mature female rats underwent ovariectomy, with one half receiving 17β-estradiol replacement (OVX+E) and the other half serving as estrogen-deficient controls (OVX). Uterine or mesenteric resistance arteries were harvested, cannulated, and pressurized. Nitric oxide and prostacyclin production were inhibited with 200 μM N G -nitro-l-arginine and 10 μM indomethacin, respectively. ACh effectively dilated the arteries preconstricted with phenylephrine but failed to induce dilation of vessels preconstricted with high-K + solution. ACh EC 50 values were decreased by estrogen replacement by five- and twofold in uterine and mesenteric arteries, respectively. As evidenced by fura-2-based measurements of EC cytoplasmic Ca 2+ concentration ([Ca 2+ ] i ), estrogen replacement was associated with increased basal and ACh-stimulated EC [Ca 2+ ] i rise in uterine, but not mesenteric, vessels. These data demonstrate that EDHF contributes to endothelium-dependent vasodilation of uterine and mesenteric resistance arteries and that estrogen controls EDHF-related mechanism(s) more efficiently in reproductive vs. nonreproductive vessels. Enhanced endothelial Ca 2+ signaling may be an important underlying mechanism in estrogenic modulation of EDHF-mediated vasodilation in small resistance uterine arteries." @default.
• W2109837218 created "2016-06-24" @default.
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• W2109837218 date "2009-03-01" @default.
• W2109837218 modified "2023-10-05" @default.
• W2109837218 title "Estrogen replacement enhances EDHF-mediated vasodilation of mesenteric and uterine resistance arteries: role of endothelial cell Ca²⁺" @default.
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• W2109837218 doi "https://doi.org/10.1152/ajpendo.90517.2008" @default.
• W2109837218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2660142" @default.
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