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• W2109849519 startingPage "1134" @default.
• W2109849519 abstract "The mechanisms underlying the failure to contain the growth of Leishmania parasites in human visceral leishmaniasis (VL) are not understood. L donovani amastigotes were quantified in cultured splenic aspirate cells to assess the function of IL-10 in lesional tissue ex vivo. In 67 patients with active VL, IL-10 neutralization promoted parasite killing in 73% and complete clearance in 30%, while 18% had more parasites and 9% did not change. The splenic cells secreted increased levels of both tumor necrosis factor α (TNFα) and interferon γ (IFNγ) under IL-10-neutralizing conditions. These findings provide direct support for targeting IL-10 as an approach to therapy in human VL." @default.
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• W2109849519 date "2011-10-01" @default.
• W2109849519 modified "2023-10-16" @default.
• W2109849519 title "IL-10 Neutralization Promotes Parasite Clearance in Splenic Aspirate Cells From Patients With Visceral Leishmaniasis" @default.
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• W2109849519 doi "https://doi.org/10.1093/infdis/jir461" @default.
• W2109849519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3164427" @default.
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