FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109851252> ?p ?o ?g. }

• W2109851252 endingPage "1680" @default.
• W2109851252 startingPage "1680" @default.
• W2109851252 abstract "To investigate the effects of heme oxygenase (HO)-1 on liver fibrosis and the expression of peroxisome proliferator-activated receptor gamma (PPARγ) and nuclear factor-kappa B (NF-κB) in rats.Sixty Wistar rats were used to construct liver fibrosis models and were randomly divided into 5 groups: group A (normal, untreated), group B (model for 4 wk, untreated), group C (model for 6 wk, untreated), group D [model for 6 wk, treated with zinc protoporphyrin IX (ZnPP-IX) from week 4 to week 6], group E (model for 6 wk, treated with hemin from week 4 to week 6). Next, liver injury was assessed by measuring serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and albumin levels. The degree of hepatic fibrosis was evaluated by measuring serum hyaluronate acid (HA), type IV collagen (IV-C) and by histological examination. Hydroxyproline (Hyp) content in the liver homogenate was determined. The expression levels of alpha-smooth muscle actin (α-SMA) in liver tissue were measured by real-time quantitative polymerase chain reaction (RT-PCR). The expression levels of PPARγ and NF-κB were determined by RT-PCR and Western blotting.The expression of HO-1 increased with the development of fibrosis. Induction of HO-1 by hemin significantly attenuated the severity of liver injury and the levels of liver fibrosis as compared with inhibition of HO-1 by ZnPP-IX. The concentrations of serum ALT, AST, HA and IV-C in group E decreased compared with group C and group D (P < 0.01). Amount of Hyp and α-SMA in the liver tissues in group E decreased compared with group C (0.62 ± 0.14 vs 0.84 ± 0.07, 1.42 ± 0.17 vs 1.84 ± 0.17, respectively, P < 0.01) and group D (0.62 ± 0.14 vs 1.11 ± 0.16, 1.42 ± 0.17 vs 2.56 ± 0.37, respectively, P < 0.01). The expression of PPARγ at levels of transcription and translation decreased with the development of fibrosis especially in group D; and it increased in group E compared with groups C and D (0.88 ± 0.15 vs 0.56 ± 0.19, 0.88 ± 0.15 vs 0.41 ± 0.11, respectively, P < 0.01). The expression of NF-κB increased with the development of fibrosis especially in group D; and it decreased in group E compared with groups C and D (1.43 ± 0.31 vs 1.89 ± 0.29, 1.43 ± 0.31 vs 2.53 ± 0.54, respectively, P < 0.01).Our data demonstrate a potential mechanism that HO-1 can prevent liver fibrosis by enhancing the expression of PPARγ and decreasing the expression of NF-κB in liver tissues." @default.
• W2109851252 created "2016-06-24" @default.
• W2109851252 creator A5003642180 @default.
• W2109851252 creator A5023599471 @default.
• W2109851252 creator A5029594740 @default.
• W2109851252 creator A5038566028 @default.
• W2109851252 creator A5043831056 @default.
• W2109851252 creator A5066716873 @default.
• W2109851252 date "2012-01-01" @default.
• W2109851252 modified "2023-10-17" @default.
• W2109851252 title "Heme oxygenase-1 prevents liver fibrosis in rats by regulating the expression of PPARγ and NF-κB" @default.
• W2109851252 cites W1021717836 @default.
• W2109851252 cites W1510312340 @default.
• W2109851252 cites W1546075224 @default.
• W2109851252 cites W173128540 @default.
• W2109851252 cites W1964123864 @default.
• W2109851252 cites W1968537918 @default.
• W2109851252 cites W1970598946 @default.
• W2109851252 cites W1973117057 @default.
• W2109851252 cites W1974618081 @default.
• W2109851252 cites W1980360532 @default.
• W2109851252 cites W1991007065 @default.
• W2109851252 cites W1991971843 @default.
• W2109851252 cites W2007164382 @default.
• W2109851252 cites W2007955597 @default.
• W2109851252 cites W2010307719 @default.
• W2109851252 cites W2023144895 @default.
• W2109851252 cites W2023565218 @default.
• W2109851252 cites W2032121833 @default.
• W2109851252 cites W2041421159 @default.
• W2109851252 cites W2045427406 @default.
• W2109851252 cites W2047884280 @default.
• W2109851252 cites W2049772445 @default.
• W2109851252 cites W2062203763 @default.
• W2109851252 cites W2066310273 @default.
• W2109851252 cites W2075473657 @default.
• W2109851252 cites W2085834865 @default.
• W2109851252 cites W2087389370 @default.
• W2109851252 cites W2092631285 @default.
• W2109851252 cites W2096286462 @default.
• W2109851252 cites W2097653082 @default.
• W2109851252 cites W2102663269 @default.
• W2109851252 cites W2105691693 @default.
• W2109851252 cites W2114100281 @default.
• W2109851252 cites W2134360290 @default.
• W2109851252 cites W2142089445 @default.
• W2109851252 cites W2147874525 @default.
• W2109851252 cites W2151296188 @default.
• W2109851252 cites W2156021051 @default.
• W2109851252 cites W2160943316 @default.
• W2109851252 cites W2170891176 @default.
• W2109851252 cites W2285434308 @default.
• W2109851252 cites W2414969725 @default.
• W2109851252 cites W62344215 @default.
• W2109851252 cites W67171789 @default.
• W2109851252 doi "https://doi.org/10.3748/wjg.v18.i14.1680" @default.
• W2109851252 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3325536" @default.
• W2109851252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22529699" @default.
• W2109851252 hasPublicationYear "2012" @default.
• W2109851252 type Work @default.
• W2109851252 sameAs 2109851252 @default.
• W2109851252 citedByCount "29" @default.
• W2109851252 countsByYear W21098512522012 @default.
• W2109851252 countsByYear W21098512522013 @default.
• W2109851252 countsByYear W21098512522014 @default.
• W2109851252 countsByYear W21098512522015 @default.
• W2109851252 countsByYear W21098512522016 @default.
• W2109851252 countsByYear W21098512522017 @default.
• W2109851252 countsByYear W21098512522018 @default.
• W2109851252 countsByYear W21098512522019 @default.
• W2109851252 countsByYear W21098512522020 @default.
• W2109851252 countsByYear W21098512522021 @default.
• W2109851252 countsByYear W21098512522022 @default.
• W2109851252 crossrefType "journal-article" @default.
• W2109851252 hasAuthorship W2109851252A5003642180 @default.
• W2109851252 hasAuthorship W2109851252A5023599471 @default.
• W2109851252 hasAuthorship W2109851252A5029594740 @default.
• W2109851252 hasAuthorship W2109851252A5038566028 @default.
• W2109851252 hasAuthorship W2109851252A5043831056 @default.
• W2109851252 hasAuthorship W2109851252A5066716873 @default.
• W2109851252 hasBestOaLocation W21098512521 @default.
• W2109851252 hasConcept C104317684 @default.
• W2109851252 hasConcept C126322002 @default.
• W2109851252 hasConcept C134018914 @default.
• W2109851252 hasConcept C170493617 @default.
• W2109851252 hasConcept C181199279 @default.
• W2109851252 hasConcept C185592680 @default.
• W2109851252 hasConcept C187345961 @default.
• W2109851252 hasConcept C2776217839 @default.
• W2109851252 hasConcept C2776637226 @default.
• W2109851252 hasConcept C2777723881 @default.
• W2109851252 hasConcept C2779219270 @default.
• W2109851252 hasConcept C2779797417 @default.
• W2109851252 hasConcept C2780559512 @default.
• W2109851252 hasConcept C2781447869 @default.
• W2109851252 hasConcept C2993667909 @default.
• W2109851252 hasConcept C55493867 @default.
• W2109851252 hasConcept C71924100 @default.

• next