Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109858742> ?p ?o ?g. }
- W2109858742 endingPage "59" @default.
- W2109858742 startingPage "45" @default.
- W2109858742 abstract "It is now well established that, in addition to its central role in the maintenance of extracellular calcium levels and bone mineralization, 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), the active form of vitamin D, also acts as a modulator of cell growth and differentiation in a number of cell types, including breast cancer cells. The anti-proliferative effects of 1,25(OH)(2)D(3) have been linked to suppression of growth stimulatory signals and potentiation of growth inhibitory signals, which lead to changes in cell cycle regulators such as p21(WAF-1/CIP1) and p27(kip1), cyclins and retinoblastoma protein as well as induction of apoptosis. Such studies have led to interest in the potential use of 1,25(OH)(2)D(3) in the treatment or prevention of certain cancers. Since this approach is limited by the tendency of 1,25(OH)(2)D(3) to cause hypercalcaemia, synthetic vitamin D analogues have been developed which display separation of the growth regulating effects from calcium mobilizing actions. This review examines mechanisms by which 1,25(OH)(2)D(3) and its active analogues exert both anti-proliferative and pro-apoptotic effects and describes some of the synthetic analogues that have been shown to be of particular interest in relation to breast cancer." @default.
- W2109858742 created "2016-06-24" @default.
- W2109858742 creator A5064836423 @default.
- W2109858742 creator A5072021346 @default.
- W2109858742 date "2002-03-01" @default.
- W2109858742 modified "2023-10-18" @default.
- W2109858742 title "Mechanisms implicated in the growth regulatory effects of vitamin D in breast cancer." @default.
- W2109858742 cites W131734221 @default.
- W2109858742 cites W1483280998 @default.
- W2109858742 cites W1502667688 @default.
- W2109858742 cites W1505801452 @default.
- W2109858742 cites W1509478882 @default.
- W2109858742 cites W1513320768 @default.
- W2109858742 cites W1521438913 @default.
- W2109858742 cites W1522008678 @default.
- W2109858742 cites W1550808631 @default.
- W2109858742 cites W1556751235 @default.
- W2109858742 cites W1558935898 @default.
- W2109858742 cites W1565310327 @default.
- W2109858742 cites W1573251222 @default.
- W2109858742 cites W1580182663 @default.
- W2109858742 cites W1604388438 @default.
- W2109858742 cites W1606469704 @default.
- W2109858742 cites W1677682824 @default.
- W2109858742 cites W1799265065 @default.
- W2109858742 cites W1853387493 @default.
- W2109858742 cites W18878644 @default.
- W2109858742 cites W1965024555 @default.
- W2109858742 cites W1968180643 @default.
- W2109858742 cites W1969688760 @default.
- W2109858742 cites W1970452226 @default.
- W2109858742 cites W1972960454 @default.
- W2109858742 cites W1976133860 @default.
- W2109858742 cites W1977960826 @default.
- W2109858742 cites W1981199654 @default.
- W2109858742 cites W1981276901 @default.
- W2109858742 cites W1982637174 @default.
- W2109858742 cites W1982704171 @default.
- W2109858742 cites W1982886830 @default.
- W2109858742 cites W1985707582 @default.
- W2109858742 cites W1986240597 @default.
- W2109858742 cites W1986537914 @default.
- W2109858742 cites W1988663027 @default.
- W2109858742 cites W1989367833 @default.
- W2109858742 cites W1994177185 @default.
- W2109858742 cites W1997387059 @default.
- W2109858742 cites W1999367143 @default.
- W2109858742 cites W2003129820 @default.
- W2109858742 cites W2003232394 @default.
- W2109858742 cites W2007852712 @default.
- W2109858742 cites W2012609761 @default.
- W2109858742 cites W2016872693 @default.
- W2109858742 cites W2018064946 @default.
- W2109858742 cites W2020809426 @default.
- W2109858742 cites W2021163920 @default.
- W2109858742 cites W2022199199 @default.
- W2109858742 cites W2022402033 @default.
- W2109858742 cites W2030965046 @default.
- W2109858742 cites W2031074006 @default.
- W2109858742 cites W2033386867 @default.
- W2109858742 cites W2036088433 @default.
- W2109858742 cites W2036381947 @default.
- W2109858742 cites W2036957227 @default.
- W2109858742 cites W2042826557 @default.
- W2109858742 cites W2043824066 @default.
- W2109858742 cites W2045450437 @default.
- W2109858742 cites W2047310942 @default.
- W2109858742 cites W2047461289 @default.
- W2109858742 cites W2048470944 @default.
- W2109858742 cites W2056889250 @default.
- W2109858742 cites W2057835336 @default.
- W2109858742 cites W2059254066 @default.
- W2109858742 cites W2059572231 @default.
- W2109858742 cites W2060137381 @default.
- W2109858742 cites W2063667483 @default.
- W2109858742 cites W2069440567 @default.
- W2109858742 cites W2069626566 @default.
- W2109858742 cites W2070004921 @default.
- W2109858742 cites W2070509236 @default.
- W2109858742 cites W2073526787 @default.
- W2109858742 cites W2074696981 @default.
- W2109858742 cites W2077227904 @default.
- W2109858742 cites W2077420287 @default.
- W2109858742 cites W2078967227 @default.
- W2109858742 cites W2080859080 @default.
- W2109858742 cites W2086488740 @default.
- W2109858742 cites W2087100948 @default.
- W2109858742 cites W2090291235 @default.
- W2109858742 cites W2094217684 @default.
- W2109858742 cites W2102225273 @default.
- W2109858742 cites W2103537398 @default.
- W2109858742 cites W2105462189 @default.
- W2109858742 cites W2108352304 @default.
- W2109858742 cites W2113968291 @default.
- W2109858742 cites W2116444950 @default.
- W2109858742 cites W2126433081 @default.
- W2109858742 cites W2126984324 @default.
- W2109858742 cites W2128291314 @default.