Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109868130> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2109868130 endingPage "A79" @default.
- W2109868130 startingPage "A78.2" @default.
- W2109868130 abstract "<h3>Background and objectives</h3> The inflammatory phase of lupus nephritis is characterised by immune cell infiltrates and develops following the deposition of immune complexes in the kidneys. Immune complex deposition is not sufficient to produce nephritis as first shown by studies of FcRγ<sup>-/-</sup> NZB/W mice (Clynes R <i>et al</i> 1998, Bergtold A <i>et al</i> 2006). The authors have recently identified a population of kidney macrophages, characterised by low surface expression of the myeloid cell marker GR1, which was required for aggressive proliferative lesions and metalloproteinase activity in poly I:C-induced and interferonα- mediated murine lupus nephritis. This population expressed IL-10, IL-1 receptor antagonist, metalloproteinases and growth factors (Triantafyllopoulou A <i>et al</i> PNAS 2010). Here, the authors aimed (A) to identify transcriptional mediators of macrophage activation in lupus nephritis kidneys and (B) to analyse blood monocyte expansion after the onset of proteinuria. <h3>Materials and methods</h3> The authors used the poly I:C model of accelerated lupus nephritis, as previously described. NZB/W mice with spontaneous proteinuria of equal duration, as well as age-matched non-proteinuric mice were used as control groups. Proteinuria was measured by dipstick. Renal disease was assessed by histopathology. Monocyte/macrophage propulations in peripheral blood or single cell suspensions of kidneys were analysed by flow cytometry. Gr1<sup>low</sup> macrophages were analysed by microarrays and real-time PCR (n=2-4 mice per group). <h3>Results</h3> GR1 low monocytes preferentially expand in the peripheral blood of poly I:C - treated nephritic mice as early as after 4 days of proteinuria. Several transcription factors associated with myeloid cell differentiation and inflammatory regulation were identified. Upregulation of IRF-7 was of particular interest and was confirmed by real time PCR. <h3>Conclusions</h3> The expansion of GR1<sup>low</sup> monocytes in a macrophage-driven model of crescentic lupus nephritis occurs at an early stage of disease in the peripheral blood compartment, thus suggesting that monocytes may be activated in lupus nephritis before their entry in the kidneys. Upregulated IRF-7 expression in infiltrating kidney macrophages suggests that macrophage-derived type I interferons may be crucial for proliferative lesions and accelerated glomerular damage." @default.
- W2109868130 created "2016-06-24" @default.
- W2109868130 creator A5021664459 @default.
- W2109868130 creator A5087516945 @default.
- W2109868130 date "2012-02-01" @default.
- W2109868130 modified "2023-09-26" @default.
- W2109868130 title "Macrophage activation in polyinosinic:polycytidylic acid-accelerated murine lupus nephritis" @default.
- W2109868130 doi "https://doi.org/10.1136/annrheumdis-2011-201238.15" @default.
- W2109868130 hasPublicationYear "2012" @default.
- W2109868130 type Work @default.
- W2109868130 sameAs 2109868130 @default.
- W2109868130 citedByCount "0" @default.
- W2109868130 crossrefType "journal-article" @default.
- W2109868130 hasAuthorship W2109868130A5021664459 @default.
- W2109868130 hasAuthorship W2109868130A5087516945 @default.
- W2109868130 hasBestOaLocation W21098681301 @default.
- W2109868130 hasConcept C126322002 @default.
- W2109868130 hasConcept C202751555 @default.
- W2109868130 hasConcept C203014093 @default.
- W2109868130 hasConcept C2776912625 @default.
- W2109868130 hasConcept C2777058396 @default.
- W2109868130 hasConcept C2779134260 @default.
- W2109868130 hasConcept C2779244956 @default.
- W2109868130 hasConcept C2779912601 @default.
- W2109868130 hasConcept C2780091579 @default.
- W2109868130 hasConcept C2780368995 @default.
- W2109868130 hasConcept C2781184567 @default.
- W2109868130 hasConcept C2908647359 @default.
- W2109868130 hasConcept C55493867 @default.
- W2109868130 hasConcept C71924100 @default.
- W2109868130 hasConcept C86803240 @default.
- W2109868130 hasConcept C8891405 @default.
- W2109868130 hasConcept C99454951 @default.
- W2109868130 hasConceptScore W2109868130C126322002 @default.
- W2109868130 hasConceptScore W2109868130C202751555 @default.
- W2109868130 hasConceptScore W2109868130C203014093 @default.
- W2109868130 hasConceptScore W2109868130C2776912625 @default.
- W2109868130 hasConceptScore W2109868130C2777058396 @default.
- W2109868130 hasConceptScore W2109868130C2779134260 @default.
- W2109868130 hasConceptScore W2109868130C2779244956 @default.
- W2109868130 hasConceptScore W2109868130C2779912601 @default.
- W2109868130 hasConceptScore W2109868130C2780091579 @default.
- W2109868130 hasConceptScore W2109868130C2780368995 @default.
- W2109868130 hasConceptScore W2109868130C2781184567 @default.
- W2109868130 hasConceptScore W2109868130C2908647359 @default.
- W2109868130 hasConceptScore W2109868130C55493867 @default.
- W2109868130 hasConceptScore W2109868130C71924100 @default.
- W2109868130 hasConceptScore W2109868130C86803240 @default.
- W2109868130 hasConceptScore W2109868130C8891405 @default.
- W2109868130 hasConceptScore W2109868130C99454951 @default.
- W2109868130 hasIssue "Suppl 1" @default.
- W2109868130 hasLocation W21098681301 @default.
- W2109868130 hasOpenAccess W2109868130 @default.
- W2109868130 hasPrimaryLocation W21098681301 @default.
- W2109868130 hasRelatedWork W1968989302 @default.
- W2109868130 hasRelatedWork W1993116843 @default.
- W2109868130 hasRelatedWork W2022776084 @default.
- W2109868130 hasRelatedWork W2032730805 @default.
- W2109868130 hasRelatedWork W2103192547 @default.
- W2109868130 hasRelatedWork W2125881570 @default.
- W2109868130 hasRelatedWork W2939681112 @default.
- W2109868130 hasRelatedWork W4308391437 @default.
- W2109868130 hasRelatedWork W4313387792 @default.
- W2109868130 hasRelatedWork W4313533128 @default.
- W2109868130 hasVolume "71" @default.
- W2109868130 isParatext "false" @default.
- W2109868130 isRetracted "false" @default.
- W2109868130 magId "2109868130" @default.
- W2109868130 workType "article" @default.