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- W2109871913 abstract "Ophthalmic manifestations of vernal keratoconjunctivitis (VKC) may be divided into actual allergic responses (giant papillae, Trantas dots) and sequelae of chronic inflammation (tarsal cicatrisation, corneal vascularisation). Mast cell-targeted therapy and anti-histamines are useful in alleviating symptoms from early pathogenic steps,1 but once T-cell-mediated reactions enter stage, these may become insufficient. A vicious cycle develops when chronic ocular surface inflammation results in tarsal scarring, secondary dry eyes and eyelid malposition. Topical steroid is indicated for severe exacerbations, but its long-term use is associated with complications such as cataract and glaucoma. Topical cyclosporine is the only commercially available in 0.05% and is indicated for aqueous deficient dry eyes. However, a previous report has shown that vernal ulcers would not respond to concentrations <1%.2Tacrolimus is more …" @default.
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- W2109871913 date "2010-06-16" @default.
- W2109871913 modified "2023-09-29" @default.
- W2109871913 title "Topical tacrolimus 0.03% monotherapy for vernal keratoconjunctivitis--case series" @default.
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- W2109871913 doi "https://doi.org/10.1136/bjo.2009.172387" @default.
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