Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109881210> ?p ?o ?g. }
- W2109881210 endingPage "2212" @default.
- W2109881210 startingPage "2201" @default.
- W2109881210 abstract "Cortical oscillations arise during behavioral and mental tasks, and all temporal oscillations have particular spatial patterns. Studying the mechanisms that generate and modulate the spatiotemporal characteristics of oscillations is important for understanding neural information processing and the signs and symptoms of dynamical diseases of the brain. Nevertheless, it remains unclear how GABAergic inhibition modulates these oscillation dynamics. Using voltage-sensitive dye imaging, pharmacological methods, and tangentially cut occipital neocortical brain slices (including layers 3-5) of Sprague-Dawley rat, we found that GABAa disinhibition with bicuculline can progressively simplify oscillation dynamics in the presence of carbachol in a concentration-dependent manner. Additionally, GABAb disinhibition can further simplify oscillation dynamics after GABAa receptors are blocked. Both GABAa and GABAb disinhibition increase the synchronization of the neural network. Theta frequency (5-15-Hz) oscillations are reliably generated by using a combination of GABAa and GABAb antagonists alone. These theta oscillations have basic spatiotemporal patterns similar to those generated by carbachol/bicuculline. These results are illustrative of how GABAergic inhibition increases the complexity of patterns of activity and contributes to the regulation of the cortex." @default.
- W2109881210 created "2016-06-24" @default.
- W2109881210 creator A5014142623 @default.
- W2109881210 creator A5015419462 @default.
- W2109881210 creator A5023399359 @default.
- W2109881210 creator A5057856027 @default.
- W2109881210 creator A5069751145 @default.
- W2109881210 creator A5088115469 @default.
- W2109881210 creator A5089630359 @default.
- W2109881210 date "2012-07-01" @default.
- W2109881210 modified "2023-10-01" @default.
- W2109881210 title "The role of inhibition in oscillatory wave dynamics in the cortex" @default.
- W2109881210 cites W1516675515 @default.
- W2109881210 cites W1536357320 @default.
- W2109881210 cites W1540301663 @default.
- W2109881210 cites W1806851391 @default.
- W2109881210 cites W1844692487 @default.
- W2109881210 cites W1912613254 @default.
- W2109881210 cites W1923614344 @default.
- W2109881210 cites W1931663848 @default.
- W2109881210 cites W1971815199 @default.
- W2109881210 cites W1974377332 @default.
- W2109881210 cites W1977504069 @default.
- W2109881210 cites W1978461659 @default.
- W2109881210 cites W1997379973 @default.
- W2109881210 cites W2000244215 @default.
- W2109881210 cites W2004937932 @default.
- W2109881210 cites W2011565599 @default.
- W2109881210 cites W2013281964 @default.
- W2109881210 cites W2014339193 @default.
- W2109881210 cites W2018379578 @default.
- W2109881210 cites W2019088085 @default.
- W2109881210 cites W2020994070 @default.
- W2109881210 cites W2037655431 @default.
- W2109881210 cites W2041359982 @default.
- W2109881210 cites W2050479285 @default.
- W2109881210 cites W2056336718 @default.
- W2109881210 cites W2058277424 @default.
- W2109881210 cites W2061544984 @default.
- W2109881210 cites W2061878522 @default.
- W2109881210 cites W2062557764 @default.
- W2109881210 cites W2064955374 @default.
- W2109881210 cites W2096131894 @default.
- W2109881210 cites W2096840793 @default.
- W2109881210 cites W2100027600 @default.
- W2109881210 cites W2101103067 @default.
- W2109881210 cites W2105003565 @default.
- W2109881210 cites W2107156550 @default.
- W2109881210 cites W2107549039 @default.
- W2109881210 cites W2107968892 @default.
- W2109881210 cites W2110802967 @default.
- W2109881210 cites W2111762111 @default.
- W2109881210 cites W2113057445 @default.
- W2109881210 cites W2113407801 @default.
- W2109881210 cites W2117985192 @default.
- W2109881210 cites W2120310258 @default.
- W2109881210 cites W2124337098 @default.
- W2109881210 cites W2126876161 @default.
- W2109881210 cites W2129153032 @default.
- W2109881210 cites W2134222376 @default.
- W2109881210 cites W2136401474 @default.
- W2109881210 cites W2137654222 @default.
- W2109881210 cites W2137976898 @default.
- W2109881210 cites W2145661927 @default.
- W2109881210 cites W2146390400 @default.
- W2109881210 cites W2148428950 @default.
- W2109881210 cites W2151229057 @default.
- W2109881210 cites W2160180788 @default.
- W2109881210 cites W2161908852 @default.
- W2109881210 cites W2165832576 @default.
- W2109881210 cites W2170187757 @default.
- W2109881210 cites W2171579695 @default.
- W2109881210 cites W2267285083 @default.
- W2109881210 cites W2290148856 @default.
- W2109881210 cites W2409599842 @default.
- W2109881210 cites W3104833475 @default.
- W2109881210 cites W4214617048 @default.
- W2109881210 doi "https://doi.org/10.1111/j.1460-9568.2012.08132.x" @default.
- W2109881210 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4410882" @default.
- W2109881210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22805065" @default.
- W2109881210 hasPublicationYear "2012" @default.
- W2109881210 type Work @default.
- W2109881210 sameAs 2109881210 @default.
- W2109881210 citedByCount "14" @default.
- W2109881210 countsByYear W21098812102012 @default.
- W2109881210 countsByYear W21098812102015 @default.
- W2109881210 countsByYear W21098812102016 @default.
- W2109881210 countsByYear W21098812102017 @default.
- W2109881210 countsByYear W21098812102018 @default.
- W2109881210 countsByYear W21098812102020 @default.
- W2109881210 countsByYear W21098812102021 @default.
- W2109881210 countsByYear W21098812102023 @default.
- W2109881210 crossrefType "journal-article" @default.
- W2109881210 hasAuthorship W2109881210A5014142623 @default.
- W2109881210 hasAuthorship W2109881210A5015419462 @default.
- W2109881210 hasAuthorship W2109881210A5023399359 @default.
- W2109881210 hasAuthorship W2109881210A5057856027 @default.
- W2109881210 hasAuthorship W2109881210A5069751145 @default.