Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109882012> ?p ?o ?g. }
- W2109882012 endingPage "112" @default.
- W2109882012 startingPage "105" @default.
- W2109882012 abstract "The effect of 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide (cPTIO), a nitric oxide (NO) scavenger that yields nitrogen dioxide (NO(2)) in a rat endotoxemia model was investigated. Endotoxin (lipopolysaccharide [LPS]) increased NO synthase (NOS) activity and inducible NOS expression measured in lung and plasma levels of nitrite/nitrate, 6-oxo-prostaglandin (PG) F(1alpha), thromboxane B(2), and PGF(2alpha). Infusion of cPTIO significantly reduced LPS-induced mean arterial blood pressure decline and mortality and selectively reduced LPS-induced 6-oxo-PGF(1alpha) plasma levels and prostacyclin synthase (PGIS) activity measured in the lung and aorta. In vitro, PGIS activity in aorta rings was not modified by SNAP (NO donor), cPTIO slightly inhibited the enzyme but not in the presence of L-N(G)-monomethyl arginine, and SNAP in combination with cPTIO significantly inhibited PGIS. Thus, cPTIO may be beneficial in endotoxic shock because of NO scavenging and PGIS inactivation, which could be mediated by NO(2)." @default.
- W2109882012 created "2016-06-24" @default.
- W2109882012 creator A5027524304 @default.
- W2109882012 creator A5029453108 @default.
- W2109882012 creator A5081697552 @default.
- W2109882012 creator A5090500376 @default.
- W2109882012 date "2001-01-01" @default.
- W2109882012 modified "2023-09-23" @default.
- W2109882012 title "Effect of an Imidazolineoxyl Nitric Oxide on Prostaglandin Synthesis in Experimental Shock: Possible Role of Nitrogen Dioxide in Prostacyclin Synthase Inactivation" @default.
- W2109882012 cites W1493899800 @default.
- W2109882012 cites W166733493 @default.
- W2109882012 cites W1725300350 @default.
- W2109882012 cites W1803493435 @default.
- W2109882012 cites W1849012281 @default.
- W2109882012 cites W1923609106 @default.
- W2109882012 cites W1967535453 @default.
- W2109882012 cites W1969425209 @default.
- W2109882012 cites W1973535328 @default.
- W2109882012 cites W1975792148 @default.
- W2109882012 cites W1977338190 @default.
- W2109882012 cites W1985473430 @default.
- W2109882012 cites W1993151749 @default.
- W2109882012 cites W2000181213 @default.
- W2109882012 cites W2000781842 @default.
- W2109882012 cites W2003359862 @default.
- W2109882012 cites W2009194142 @default.
- W2109882012 cites W2011552468 @default.
- W2109882012 cites W2013333822 @default.
- W2109882012 cites W2016367914 @default.
- W2109882012 cites W2021324668 @default.
- W2109882012 cites W2026683387 @default.
- W2109882012 cites W2030677909 @default.
- W2109882012 cites W2032092394 @default.
- W2109882012 cites W2035246932 @default.
- W2109882012 cites W2044709352 @default.
- W2109882012 cites W2048839667 @default.
- W2109882012 cites W2050324047 @default.
- W2109882012 cites W2051819610 @default.
- W2109882012 cites W2058137293 @default.
- W2109882012 cites W2066141836 @default.
- W2109882012 cites W2071119584 @default.
- W2109882012 cites W2092175186 @default.
- W2109882012 cites W2101957581 @default.
- W2109882012 cites W2103766497 @default.
- W2109882012 cites W2109893157 @default.
- W2109882012 cites W2112736947 @default.
- W2109882012 cites W2139328513 @default.
- W2109882012 cites W2155791167 @default.
- W2109882012 cites W2167859431 @default.
- W2109882012 cites W2170457471 @default.
- W2109882012 cites W2409458552 @default.
- W2109882012 cites W39040643 @default.
- W2109882012 doi "https://doi.org/10.1086/317639" @default.
- W2109882012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11076704" @default.
- W2109882012 hasPublicationYear "2001" @default.
- W2109882012 type Work @default.
- W2109882012 sameAs 2109882012 @default.
- W2109882012 citedByCount "14" @default.
- W2109882012 countsByYear W21098820122013 @default.
- W2109882012 crossrefType "journal-article" @default.
- W2109882012 hasAuthorship W2109882012A5027524304 @default.
- W2109882012 hasAuthorship W2109882012A5029453108 @default.
- W2109882012 hasAuthorship W2109882012A5081697552 @default.
- W2109882012 hasAuthorship W2109882012A5090500376 @default.
- W2109882012 hasBestOaLocation W21098820121 @default.
- W2109882012 hasConcept C170493617 @default.
- W2109882012 hasConcept C178790620 @default.
- W2109882012 hasConcept C185592680 @default.
- W2109882012 hasConcept C203014093 @default.
- W2109882012 hasConcept C2777622882 @default.
- W2109882012 hasConcept C2778754761 @default.
- W2109882012 hasConcept C2780664492 @default.
- W2109882012 hasConcept C2781024287 @default.
- W2109882012 hasConcept C2781128415 @default.
- W2109882012 hasConcept C519581460 @default.
- W2109882012 hasConcept C55493867 @default.
- W2109882012 hasConcept C86803240 @default.
- W2109882012 hasConcept C98274493 @default.
- W2109882012 hasConceptScore W2109882012C170493617 @default.
- W2109882012 hasConceptScore W2109882012C178790620 @default.
- W2109882012 hasConceptScore W2109882012C185592680 @default.
- W2109882012 hasConceptScore W2109882012C203014093 @default.
- W2109882012 hasConceptScore W2109882012C2777622882 @default.
- W2109882012 hasConceptScore W2109882012C2778754761 @default.
- W2109882012 hasConceptScore W2109882012C2780664492 @default.
- W2109882012 hasConceptScore W2109882012C2781024287 @default.
- W2109882012 hasConceptScore W2109882012C2781128415 @default.
- W2109882012 hasConceptScore W2109882012C519581460 @default.
- W2109882012 hasConceptScore W2109882012C55493867 @default.
- W2109882012 hasConceptScore W2109882012C86803240 @default.
- W2109882012 hasConceptScore W2109882012C98274493 @default.
- W2109882012 hasIssue "1" @default.
- W2109882012 hasLocation W21098820121 @default.
- W2109882012 hasLocation W21098820122 @default.
- W2109882012 hasOpenAccess W2109882012 @default.
- W2109882012 hasPrimaryLocation W21098820121 @default.
- W2109882012 hasRelatedWork W1968811274 @default.
- W2109882012 hasRelatedWork W1985900017 @default.