FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109887218> ?p ?o ?g. }

• W2109887218 endingPage "677" @default.
• W2109887218 startingPage "665" @default.
• W2109887218 abstract "CD4+ T cells with pre‐defined MHC‐unrestricted specificity to type II collagen (CII) were engineered for cell‐based anti‐inflammatory gene therapy of autoimmune arthritis. To this end, recombinant chimeric immunoreceptors, C2γ or C2ζ, were expressed in primary mouse keyhole limpet hemocyanin (KLH)‐specific Th1 and Th2 cells using retrovirus vector‐based somatic cell gene transfer. The ectodomain of these tyrosine‐based activation motif (ITAM)‐containing immunoreceptors is a single‐chain IgG variable domain of an anti‐CII mAb. The engineered cells might arrest migration when they encounter CII in articular cartilage. Up to 19 and 55% of transduced CD4+ T cells expressed respectively C2γ and C2ζ. The expression of C2γ or C2ζ on the surface of CD4+ T cells was down‐regulated upon binding CII, and cells activated in such a way proliferated, up‐regulated CD25 expression and produced cytokines. Comparison of cytokine levels normalized by the number of producer cells revealed that C2γ and C2ζ were as potent as TCR in the induction of IFN‐γ, but induced lower levels of IL‐4. It appears that the reason why CD4+ T cells stimulated through C2γ and C2ζ produce low levels of IL‐4 is a lack of integration between co‐stimulatory signals required for the optimal production of this cytokine and the ITAM‐dependent signals generated by the immunoreceptors. The significance of these data for the development of anti‐inflammatory gene therapy based on CD4+ T cells targeted to a tissue‐specific protein is discussed." @default.
• W2109887218 created "2016-06-24" @default.
• W2109887218 creator A5006512036 @default.
• W2109887218 creator A5033052106 @default.
• W2109887218 creator A5046338780 @default.
• W2109887218 creator A5077515411 @default.
• W2109887218 date "2003-05-01" @default.
• W2109887218 modified "2023-10-16" @default.
• W2109887218 title "Clustering of immunoreceptor tyrosine-based activation motif-containing signalling subunits in CD4+ T cells is an optimal signal for IFN-gamma production, but not for the production of IL-4" @default.
• W2109887218 cites W1500563338 @default.
• W2109887218 cites W1618716816 @default.
• W2109887218 cites W1667815498 @default.
• W2109887218 cites W1669027738 @default.
• W2109887218 cites W1898621392 @default.
• W2109887218 cites W1971050137 @default.
• W2109887218 cites W1973978245 @default.
• W2109887218 cites W1982425773 @default.
• W2109887218 cites W1988707760 @default.
• W2109887218 cites W1993884243 @default.
• W2109887218 cites W1994001196 @default.
• W2109887218 cites W1998415250 @default.
• W2109887218 cites W2014154395 @default.
• W2109887218 cites W2025271699 @default.
• W2109887218 cites W2028460943 @default.
• W2109887218 cites W2028842451 @default.
• W2109887218 cites W2036540579 @default.
• W2109887218 cites W2040838085 @default.
• W2109887218 cites W2041525823 @default.
• W2109887218 cites W2042209841 @default.
• W2109887218 cites W2042582068 @default.
• W2109887218 cites W2054851985 @default.
• W2109887218 cites W2070437307 @default.
• W2109887218 cites W2079837731 @default.
• W2109887218 cites W2083548214 @default.
• W2109887218 cites W2090097978 @default.
• W2109887218 cites W2101990345 @default.
• W2109887218 cites W2110648582 @default.
• W2109887218 cites W2110826122 @default.
• W2109887218 cites W2114829069 @default.
• W2109887218 cites W2115244335 @default.
• W2109887218 cites W2116547987 @default.
• W2109887218 cites W2120389604 @default.
• W2109887218 cites W2129896296 @default.
• W2109887218 cites W2133926860 @default.
• W2109887218 cites W2134033073 @default.
• W2109887218 cites W2137407985 @default.
• W2109887218 cites W2139229993 @default.
• W2109887218 cites W2145963061 @default.
• W2109887218 cites W2146660124 @default.
• W2109887218 cites W2152627462 @default.
• W2109887218 cites W2164845999 @default.
• W2109887218 cites W2166487857 @default.
• W2109887218 cites W2323474162 @default.
• W2109887218 cites W2330440154 @default.
• W2109887218 cites W2397692860 @default.
• W2109887218 cites W75602434 @default.
• W2109887218 cites W2169183747 @default.
• W2109887218 doi "https://doi.org/10.1093/intimm/dxg064" @default.
• W2109887218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12697666" @default.
• W2109887218 hasPublicationYear "2003" @default.
• W2109887218 type Work @default.
• W2109887218 sameAs 2109887218 @default.
• W2109887218 citedByCount "6" @default.
• W2109887218 crossrefType "journal-article" @default.
• W2109887218 hasAuthorship W2109887218A5006512036 @default.
• W2109887218 hasAuthorship W2109887218A5033052106 @default.
• W2109887218 hasAuthorship W2109887218A5046338780 @default.
• W2109887218 hasAuthorship W2109887218A5077515411 @default.
• W2109887218 hasConcept C1009742 @default.
• W2109887218 hasConcept C148125776 @default.
• W2109887218 hasConcept C153911025 @default.
• W2109887218 hasConcept C170493617 @default.
• W2109887218 hasConcept C185592680 @default.
• W2109887218 hasConcept C19317047 @default.
• W2109887218 hasConcept C203014093 @default.
• W2109887218 hasConcept C2776090121 @default.
• W2109887218 hasConcept C2778690821 @default.
• W2109887218 hasConcept C29907709 @default.
• W2109887218 hasConcept C55493867 @default.
• W2109887218 hasConcept C79484868 @default.
• W2109887218 hasConcept C86803240 @default.
• W2109887218 hasConcept C8891405 @default.
• W2109887218 hasConcept C95444343 @default.
• W2109887218 hasConceptScore W2109887218C1009742 @default.
• W2109887218 hasConceptScore W2109887218C148125776 @default.
• W2109887218 hasConceptScore W2109887218C153911025 @default.
• W2109887218 hasConceptScore W2109887218C170493617 @default.
• W2109887218 hasConceptScore W2109887218C185592680 @default.
• W2109887218 hasConceptScore W2109887218C19317047 @default.
• W2109887218 hasConceptScore W2109887218C203014093 @default.
• W2109887218 hasConceptScore W2109887218C2776090121 @default.
• W2109887218 hasConceptScore W2109887218C2778690821 @default.
• W2109887218 hasConceptScore W2109887218C29907709 @default.
• W2109887218 hasConceptScore W2109887218C55493867 @default.
• W2109887218 hasConceptScore W2109887218C79484868 @default.
• W2109887218 hasConceptScore W2109887218C86803240 @default.
• W2109887218 hasConceptScore W2109887218C8891405 @default.
• W2109887218 hasConceptScore W2109887218C95444343 @default.

• next