FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109890354> ?p ?o ?g. }

• W2109890354 endingPage "e138" @default.
• W2109890354 startingPage "e138" @default.
• W2109890354 abstract "RNA editing regulates mitochondrial gene expression in trypanosomatid pathogens by creating functional mRNAs. It is catalyzed by a multi-protein complex (the editosome), and is found to be essential in both insect stage and mammalian blood stream form of Trypanosoma brucei . This particular form of RNA editing is unique to trypanosomatids, and thus provides a suitable drug target in trypanosomatid pathogens. Here, we demonstrate the feasibility of a rapid and sensitive fluorescence-based reporter assay to monitor RNA editing based on ribozyme activity. We could validate our new assay using previously identified inhibitors against the essential RNA editing ligase. The principle advantages of this assay are: (i) the use of non-radioactively labeled materials, (ii) sensitivity afforded by fluorescence instrumentation applicable to high-throughput screening of chemical inhibitors against the essential editosome and (iii) a rapid and convenient ‘mix and measure’ type of assay in low volume with a high signal to noise ratio. This assay should enhance rapid identification and characterization of the editosome inhibitors primarily based on the overall composition of the editosomes from T. brucei . These inhibitors could also be tested against the editosomes from the closely related pathogens including T. cruzi and Leishmania species." @default.
• W2109890354 created "2016-06-24" @default.
• W2109890354 creator A5018784737 @default.
• W2109890354 creator A5049563652 @default.
• W2109890354 date "2010-05-05" @default.
• W2109890354 modified "2023-09-26" @default.
• W2109890354 title "A fluorescence-based reporter substrate for monitoring RNA editing in trypanosomatid pathogens" @default.
• W2109890354 cites W1510686779 @default.
• W2109890354 cites W1622719173 @default.
• W2109890354 cites W1964869212 @default.
• W2109890354 cites W1968354620 @default.
• W2109890354 cites W1972534051 @default.
• W2109890354 cites W1991001144 @default.
• W2109890354 cites W2014767243 @default.
• W2109890354 cites W2046703384 @default.
• W2109890354 cites W2051075703 @default.
• W2109890354 cites W2055625001 @default.
• W2109890354 cites W2066390447 @default.
• W2109890354 cites W2070211116 @default.
• W2109890354 cites W2071373035 @default.
• W2109890354 cites W2080653091 @default.
• W2109890354 cites W2094091020 @default.
• W2109890354 cites W2104258472 @default.
• W2109890354 cites W2114306163 @default.
• W2109890354 cites W2121692632 @default.
• W2109890354 cites W2125828540 @default.
• W2109890354 cites W2128472821 @default.
• W2109890354 cites W2130653277 @default.
• W2109890354 cites W2131004367 @default.
• W2109890354 cites W2132846647 @default.
• W2109890354 cites W2133622974 @default.
• W2109890354 cites W2135534435 @default.
• W2109890354 cites W2137195660 @default.
• W2109890354 cites W2138444917 @default.
• W2109890354 cites W2145707143 @default.
• W2109890354 cites W2147973202 @default.
• W2109890354 cites W2160942775 @default.
• W2109890354 cites W2165916034 @default.
• W2109890354 cites W2168140297 @default.
• W2109890354 cites W2169523472 @default.
• W2109890354 cites W2314959220 @default.
• W2109890354 cites W2346771435 @default.
• W2109890354 cites W2398808997 @default.
• W2109890354 cites W278250405 @default.
• W2109890354 cites W4212858354 @default.
• W2109890354 cites W4232297913 @default.
• W2109890354 cites W4253038723 @default.
• W2109890354 doi "https://doi.org/10.1093/nar/gkq333" @default.
• W2109890354 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2910069" @default.
• W2109890354 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20444864" @default.
• W2109890354 hasPublicationYear "2010" @default.
• W2109890354 type Work @default.
• W2109890354 sameAs 2109890354 @default.
• W2109890354 citedByCount "12" @default.
• W2109890354 countsByYear W21098903542012 @default.
• W2109890354 countsByYear W21098903542013 @default.
• W2109890354 countsByYear W21098903542014 @default.
• W2109890354 countsByYear W21098903542015 @default.
• W2109890354 countsByYear W21098903542016 @default.
• W2109890354 countsByYear W21098903542020 @default.
• W2109890354 countsByYear W21098903542022 @default.
• W2109890354 crossrefType "journal-article" @default.
• W2109890354 hasAuthorship W2109890354A5018784737 @default.
• W2109890354 hasAuthorship W2109890354A5049563652 @default.
• W2109890354 hasBestOaLocation W21098903541 @default.
• W2109890354 hasConcept C104317684 @default.
• W2109890354 hasConcept C141231307 @default.
• W2109890354 hasConcept C144501496 @default.
• W2109890354 hasConcept C21786251 @default.
• W2109890354 hasConcept C2779502636 @default.
• W2109890354 hasConcept C55493867 @default.
• W2109890354 hasConcept C67705224 @default.
• W2109890354 hasConcept C70721500 @default.
• W2109890354 hasConcept C76346623 @default.
• W2109890354 hasConcept C86803240 @default.
• W2109890354 hasConcept C97702854 @default.
• W2109890354 hasConceptScore W2109890354C104317684 @default.
• W2109890354 hasConceptScore W2109890354C141231307 @default.
• W2109890354 hasConceptScore W2109890354C144501496 @default.
• W2109890354 hasConceptScore W2109890354C21786251 @default.
• W2109890354 hasConceptScore W2109890354C2779502636 @default.
• W2109890354 hasConceptScore W2109890354C55493867 @default.
• W2109890354 hasConceptScore W2109890354C67705224 @default.
• W2109890354 hasConceptScore W2109890354C70721500 @default.
• W2109890354 hasConceptScore W2109890354C76346623 @default.
• W2109890354 hasConceptScore W2109890354C86803240 @default.
• W2109890354 hasConceptScore W2109890354C97702854 @default.
• W2109890354 hasIssue "13" @default.
• W2109890354 hasLocation W21098903541 @default.
• W2109890354 hasLocation W21098903542 @default.
• W2109890354 hasLocation W21098903543 @default.
• W2109890354 hasLocation W21098903544 @default.
• W2109890354 hasLocation W21098903545 @default.
• W2109890354 hasOpenAccess W2109890354 @default.
• W2109890354 hasPrimaryLocation W21098903541 @default.
• W2109890354 hasRelatedWork W2013022956 @default.
• W2109890354 hasRelatedWork W2023272515 @default.
• W2109890354 hasRelatedWork W2023988982 @default.

• next