FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109906075> ?p ?o ?g. }

• W2109906075 endingPage "818" @default.
• W2109906075 startingPage "810" @default.
• W2109906075 abstract "Disease stage is the most important prognostic parameter in allogeneic hematopoietic cell transplantation (HCT) for acute lymphoblastic leukemia, but other factors such as donor/host histocompatibility and gender combination, recipient age, performance status and comorbidities need to be considered. Several scoring systems are available to predict outcome in HCT recipients; however, their prognostic relevance in acute lymphoblastic leukemia is not well defined.In the present study we evaluated a modified EBMT risk score (mEBMT) and the HCT-specific comorbidity index (HCT-CI) in 151 adult acute lymphoblastic leukemia patients who received allogeneic HCT from 1995 until 2007 at our center.Disease status was first complete remission (CR1) (47%), CR>1 (21%) or no CR (32%). Overall survival (OS) at one, two and five years was 62%, 51% and 40% and non-relapse mortality (NRM) was 21%, 24% and 32%. Median mEBMT was 3 (0-6). Higher mEBMT was associated with inferior OS (hazard ratio per score unit (HR): 1.50, P<0.001), higher NRM (HR: 1.36, P=0.042) and higher relapse mortality (HR: 1.68, P<0.001). Disease stage was the predominant prognostic factor in this score. Comorbidities were present in 71% of patients with mild hepatic disease (29%), moderate pulmonary disease (28%) and infections (23%) being the most common. Median HCT-CI was 1 (0-9). In univariate analysis a trend for inferior OS (HR: 1.08, P=0.20) and higher NRM (HR: 1.14, P=0.11) with increasing HCT-CI was observed but the level of significance was not reached. In additional analyses we found that reduced Karnofsky Performance Status (KPS) was associated with inferior OS (HR: 1.34, P=0.023) and higher relapse mortality (HR: 1.71, P=0.001) when analyzed univariately. However, KPS was associated with disease stage and significance was lost in multivariate analysis.The mEBMT was prognostic in our patient cohort with predominant influence of disease stage, whereas a trend but no significant prognostic value was observed for the HCT-CI." @default.
• W2109906075 created "2016-06-24" @default.
• W2109906075 creator A5007955909 @default.
• W2109906075 creator A5008552757 @default.
• W2109906075 creator A5031288271 @default.
• W2109906075 creator A5037027188 @default.
• W2109906075 creator A5048007851 @default.
• W2109906075 creator A5084457753 @default.
• W2109906075 creator A5086465315 @default.
• W2109906075 creator A5089180847 @default.
• W2109906075 date "2009-12-08" @default.
• W2109906075 modified "2023-10-12" @default.
• W2109906075 title "A modified EBMT risk score and the hematopoietic cell transplantation-specific comorbidity index for pre-transplant risk assessment in adult acute lymphoblastic leukemia" @default.
• W2109906075 cites W1971086160 @default.
• W2109906075 cites W1971439170 @default.
• W2109906075 cites W1974452979 @default.
• W2109906075 cites W1974938631 @default.
• W2109906075 cites W1992239002 @default.
• W2109906075 cites W1998627443 @default.
• W2109906075 cites W1999533140 @default.
• W2109906075 cites W1999638841 @default.
• W2109906075 cites W2004459801 @default.
• W2109906075 cites W2010222433 @default.
• W2109906075 cites W2012538864 @default.
• W2109906075 cites W2022794150 @default.
• W2109906075 cites W2041925366 @default.
• W2109906075 cites W2047820848 @default.
• W2109906075 cites W2055313377 @default.
• W2109906075 cites W2060247824 @default.
• W2109906075 cites W2060850302 @default.
• W2109906075 cites W2062871466 @default.
• W2109906075 cites W2073140442 @default.
• W2109906075 cites W2078782557 @default.
• W2109906075 cites W2079011262 @default.
• W2109906075 cites W2083163868 @default.
• W2109906075 cites W2085110573 @default.
• W2109906075 cites W2087548983 @default.
• W2109906075 cites W2097534024 @default.
• W2109906075 cites W2103529718 @default.
• W2109906075 cites W2104553892 @default.
• W2109906075 cites W2104711659 @default.
• W2109906075 cites W2111779071 @default.
• W2109906075 cites W2117550229 @default.
• W2109906075 cites W2117730045 @default.
• W2109906075 cites W2120756704 @default.
• W2109906075 cites W2122514970 @default.
• W2109906075 cites W2123711386 @default.
• W2109906075 cites W2128812336 @default.
• W2109906075 cites W2148449018 @default.
• W2109906075 cites W2156617860 @default.
• W2109906075 cites W2164819375 @default.
• W2109906075 cites W2181373645 @default.
• W2109906075 cites W2414080829 @default.
• W2109906075 cites W1989378168 @default.
• W2109906075 doi "https://doi.org/10.3324/haematol.2009.011809" @default.
• W2109906075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2864388" @default.
• W2109906075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20007143" @default.
• W2109906075 hasPublicationYear "2009" @default.
• W2109906075 type Work @default.
• W2109906075 sameAs 2109906075 @default.
• W2109906075 citedByCount "61" @default.
• W2109906075 countsByYear W21099060752012 @default.
• W2109906075 countsByYear W21099060752013 @default.
• W2109906075 countsByYear W21099060752014 @default.
• W2109906075 countsByYear W21099060752015 @default.
• W2109906075 countsByYear W21099060752016 @default.
• W2109906075 countsByYear W21099060752017 @default.
• W2109906075 countsByYear W21099060752018 @default.
• W2109906075 countsByYear W21099060752019 @default.
• W2109906075 countsByYear W21099060752020 @default.
• W2109906075 countsByYear W21099060752021 @default.
• W2109906075 countsByYear W21099060752022 @default.
• W2109906075 countsByYear W21099060752023 @default.
• W2109906075 crossrefType "journal-article" @default.
• W2109906075 hasAuthorship W2109906075A5007955909 @default.
• W2109906075 hasAuthorship W2109906075A5008552757 @default.
• W2109906075 hasAuthorship W2109906075A5031288271 @default.
• W2109906075 hasAuthorship W2109906075A5037027188 @default.
• W2109906075 hasAuthorship W2109906075A5048007851 @default.
• W2109906075 hasAuthorship W2109906075A5084457753 @default.
• W2109906075 hasAuthorship W2109906075A5086465315 @default.
• W2109906075 hasAuthorship W2109906075A5089180847 @default.
• W2109906075 hasBestOaLocation W21099060751 @default.
• W2109906075 hasConcept C126322002 @default.
• W2109906075 hasConcept C143998085 @default.
• W2109906075 hasConcept C144301174 @default.
• W2109906075 hasConcept C207103383 @default.
• W2109906075 hasConcept C2776863199 @default.
• W2109906075 hasConcept C2777408962 @default.
• W2109906075 hasConcept C2778461978 @default.
• W2109906075 hasConcept C2779159551 @default.
• W2109906075 hasConcept C2911091166 @default.
• W2109906075 hasConcept C38180746 @default.
• W2109906075 hasConcept C44249647 @default.
• W2109906075 hasConcept C50382708 @default.
• W2109906075 hasConcept C71924100 @default.
• W2109906075 hasConceptScore W2109906075C126322002 @default.
• W2109906075 hasConceptScore W2109906075C143998085 @default.

• next