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- W2109923675 abstract "Although microRNAs (miRNAs) are among the most intensively studied molecules of the past 20 years, determining what is and what is not a miRNA has not been straightforward. Here, we present a uniform system for the annotation and nomenclature of miRNA genes. We show that less than a third of the 1,881 human miRBase entries, and only approximately 16% of the 7,095 metazoan miRBase entries, are robustly supported as miRNA genes. Furthermore, we show that the human repertoire of miRNAs has been shaped by periods of intense miRNA innovation and that mature gene products show a very different tempo and mode of sequence evolution than star products. We establish a new open access database--MirGeneDB ( http://mirgenedb.org )--to catalog this set of miRNAs, which complements the efforts of miRBase but differs from it by annotating the mature versus star products and by imposing an evolutionary hierarchy upon this curated and consistently named repertoire." @default.
- W2109923675 created "2016-06-24" @default.
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- W2109923675 date "2015-11-23" @default.
- W2109923675 modified "2023-10-06" @default.
- W2109923675 title "A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome" @default.
- W2109923675 cites W1479910578 @default.
- W2109923675 cites W1537472265 @default.
- W2109923675 cites W1542414309 @default.
- W2109923675 cites W1543931293 @default.
- W2109923675 cites W1648301895 @default.
- W2109923675 cites W1744683414 @default.
- W2109923675 cites W1832399013 @default.
- W2109923675 cites W1852268638 @default.
- W2109923675 cites W1933984608 @default.
- W2109923675 cites W1934357283 @default.
- W2109923675 cites W1956319726 @default.
- W2109923675 cites W1967030247 @default.
- W2109923675 cites W1968421082 @default.
- W2109923675 cites W1968525732 @default.
- W2109923675 cites W1969234199 @default.
- W2109923675 cites W1970863767 @default.
- W2109923675 cites W1971623350 @default.
- W2109923675 cites W1972411174 @default.
- W2109923675 cites W1973158080 @default.
- W2109923675 cites W1974220890 @default.
- W2109923675 cites W1976341065 @default.
- W2109923675 cites W1977064582 @default.
- W2109923675 cites W1977279728 @default.
- W2109923675 cites W1979285004 @default.
- W2109923675 cites W1979390153 @default.
- W2109923675 cites W1982110977 @default.
- W2109923675 cites W1989015932 @default.
- W2109923675 cites W1991153319 @default.
- W2109923675 cites W1992941735 @default.
- W2109923675 cites W1993533777 @default.
- W2109923675 cites W1996466164 @default.
- W2109923675 cites W1997639391 @default.
- W2109923675 cites W1999675792 @default.
- W2109923675 cites W2001003536 @default.
- W2109923675 cites W2001554877 @default.
- W2109923675 cites W2001911979 @default.
- W2109923675 cites W2002995168 @default.
- W2109923675 cites W2004791359 @default.
- W2109923675 cites W2005711322 @default.
- W2109923675 cites W2007976384 @default.
- W2109923675 cites W2009371644 @default.
- W2109923675 cites W2009658305 @default.
- W2109923675 cites W2011920499 @default.
- W2109923675 cites W2013868665 @default.
- W2109923675 cites W2015284016 @default.
- W2109923675 cites W2015858554 @default.
- W2109923675 cites W2016053029 @default.
- W2109923675 cites W2017426710 @default.
- W2109923675 cites W2020596227 @default.
- W2109923675 cites W2022199909 @default.
- W2109923675 cites W2022326327 @default.
- W2109923675 cites W2023894577 @default.
- W2109923675 cites W2024045457 @default.
- W2109923675 cites W2026099724 @default.
- W2109923675 cites W2027599886 @default.
- W2109923675 cites W2028444170 @default.
- W2109923675 cites W2028561445 @default.
- W2109923675 cites W2029532148 @default.
- W2109923675 cites W2029919331 @default.
- W2109923675 cites W2032200822 @default.
- W2109923675 cites W2036288429 @default.
- W2109923675 cites W2039415806 @default.
- W2109923675 cites W2040851473 @default.
- W2109923675 cites W2046387002 @default.
- W2109923675 cites W2047405437 @default.
- W2109923675 cites W2047884402 @default.
- W2109923675 cites W2049836150 @default.
- W2109923675 cites W2050809893 @default.
- W2109923675 cites W2053003053 @default.
- W2109923675 cites W2053078446 @default.
- W2109923675 cites W2054752311 @default.
- W2109923675 cites W2056646263 @default.
- W2109923675 cites W2058615001 @default.
- W2109923675 cites W2059073003 @default.
- W2109923675 cites W2064616149 @default.
- W2109923675 cites W2065636600 @default.
- W2109923675 cites W2067547077 @default.
- W2109923675 cites W2068205741 @default.
- W2109923675 cites W2071596792 @default.
- W2109923675 cites W2072449468 @default.
- W2109923675 cites W2074624286 @default.
- W2109923675 cites W2077327925 @default.