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• W2109929534 abstract "Human papillomavirus (HPV) is the major cause of cervical neoplasia but estimates of the population attributable fraction (PAR%), of HPV vary. PAR% has not been derived from longitudinal studies although assessment of HPV exposure prior to the neoplasia diagnosis should increase validity of such estimates.Systematic review and meta-analysis of longitudinal studies on HPV associated relative risk (RR) for and PAR% of HPV16 in cervical neoplasia.Pertinent data from longitudinal studies was made available through Medline and substituted by various hand searches. HPV associated weighted mean RR, with 95% confidence interval (CI) of cervical neoplasia, and the PAR% of HPV16 in cervical carcinoma were estimated both for unselected and low HPV prevalence populations.HPV associated RR of cervical carcinoma in PCR-based studies was 17 (95% CI 8.2-33). HPV16 associated RRs in seroepidemiological studies were 3.3 (95% CI 2.2-4.9) for the unselected population, HPV16 seroprevalence 11.0%, and 12.5 (95% CI 5.5-29) for a population with low HPV16 seroprevalence of 5.3%. Corresponding PAR% estimates of HPV16 were 27 and 44%, respectively.Protective vaccination against HPV16 infection would prevent up to 44% of cervical carcinoma." @default.
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• W2109929534 date "2001-08-01" @default.
• W2109929534 modified "2023-10-15" @default.
• W2109929534 title "Human papillomavirus infection, risk for subsequent development of cervical neoplasia and associated population attributable fraction" @default.
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• W2109929534 doi "https://doi.org/10.1016/s1386-6532(01)00172-x" @default.
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