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• W2109968126 abstract "Abstract We previously reported that rOv-ASP-1, a recombinant Onchocerca volvulus activation associated protein-1, was a potent adjuvant for recombinant protein or synthetic peptide-based Ags. In this study, we further evaluated the adjuvanticity of rOv-ASP-1 and explored its mechanism of action. Consistently, recombinant full-length spike protein of SARS-CoV or its receptor-binding domain in the presence of rOv-ASP-1 could effectively induce a mixed but Th1-skewed immune response in immunized mice. It appears that rOv-ASP-1 primarily bound to the APCs among human PBMCs and triggered Th1-biased proinflammatory cytokine production probably via the activation of monocyte-derived dendritic cells and the TLR, TLR2, and TLR4, thus suggesting that rOv-ASP-1 is a novel potent innate adjuvant." @default.
• W2109968126 created "2016-06-24" @default.
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• W2109968126 date "2009-04-01" @default.
• W2109968126 modified "2023-10-01" @default.
• W2109968126 title "Recombinant <i>Ov</i>-ASP-1, a Th1-Biased Protein Adjuvant Derived from the Helminth <i>Onchocerca volvulus</i>, Can Directly Bind and Activate Antigen-Presenting Cells" @default.
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• W2109968126 doi "https://doi.org/10.4049/jimmunol.0800531" @default.
• W2109968126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19299698" @default.
• W2109968126 hasPublicationYear "2009" @default.
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