Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109968192> ?p ?o ?g. }
- W2109968192 endingPage "2109" @default.
- W2109968192 startingPage "2093" @default.
- W2109968192 abstract "Individual studies indicate that kidney transplantation is associated with lower mortality and improved quality of life compared with chronic dialysis treatment. We did a systematic review to summarize the benefits of transplantation, aiming to identify characteristics associated with especially large or small relative benefit. Results were not pooled because of expected diversity inherent to observational studies. Risk of bias was assessed using the Downs and Black checklist and items related to time-to-event analysis techniques. MEDLINE and EMBASE were searched up to February 2010. Cohort studies comparing adult chronic dialysis patients with kidney transplantation recipients for clinical outcomes were selected. We identified 110 eligible studies with a total of 1 922 300 participants. Most studies found significantly lower mortality associated with transplantation, and the relative magnitude of the benefit seemed to increase over time (p < 0.001). Most studies also found that the risk of cardiovascular events was significantly reduced among transplant recipients. Quality of life was significantly and substantially better among transplant recipients. Despite increases in the age and comorbidity of contemporary transplant recipients, the relative benefits of transplantation seem to be increasing over time. These findings validate current attempts to increase the number of people worldwide that benefit from kidney transplantation. Individual studies indicate that kidney transplantation is associated with lower mortality and improved quality of life compared with chronic dialysis treatment. We did a systematic review to summarize the benefits of transplantation, aiming to identify characteristics associated with especially large or small relative benefit. Results were not pooled because of expected diversity inherent to observational studies. Risk of bias was assessed using the Downs and Black checklist and items related to time-to-event analysis techniques. MEDLINE and EMBASE were searched up to February 2010. Cohort studies comparing adult chronic dialysis patients with kidney transplantation recipients for clinical outcomes were selected. We identified 110 eligible studies with a total of 1 922 300 participants. Most studies found significantly lower mortality associated with transplantation, and the relative magnitude of the benefit seemed to increase over time (p < 0.001). Most studies also found that the risk of cardiovascular events was significantly reduced among transplant recipients. Quality of life was significantly and substantially better among transplant recipients. Despite increases in the age and comorbidity of contemporary transplant recipients, the relative benefits of transplantation seem to be increasing over time. These findings validate current attempts to increase the number of people worldwide that benefit from kidney transplantation." @default.
- W2109968192 created "2016-06-24" @default.
- W2109968192 creator A5009624452 @default.
- W2109968192 creator A5029002467 @default.
- W2109968192 creator A5033662895 @default.
- W2109968192 creator A5034928512 @default.
- W2109968192 creator A5042550440 @default.
- W2109968192 creator A5046137699 @default.
- W2109968192 creator A5068783690 @default.
- W2109968192 creator A5070692342 @default.
- W2109968192 date "2011-10-01" @default.
- W2109968192 modified "2023-10-11" @default.
- W2109968192 title "Systematic Review: Kidney Transplantation Compared With Dialysis in Clinically Relevant Outcomes" @default.
- W2109968192 cites W1927874785 @default.
- W2109968192 cites W1965555814 @default.
- W2109968192 cites W1968948946 @default.
- W2109968192 cites W1969662158 @default.
- W2109968192 cites W1971278669 @default.
- W2109968192 cites W1971611334 @default.
- W2109968192 cites W197185462 @default.
- W2109968192 cites W1972078928 @default.
- W2109968192 cites W1976884386 @default.
- W2109968192 cites W1977198938 @default.
- W2109968192 cites W1977754664 @default.
- W2109968192 cites W1979423827 @default.
- W2109968192 cites W1990369801 @default.
- W2109968192 cites W1990425972 @default.
- W2109968192 cites W1992554486 @default.
- W2109968192 cites W1994089703 @default.
- W2109968192 cites W2000355519 @default.
- W2109968192 cites W2002065372 @default.
- W2109968192 cites W2003765818 @default.
- W2109968192 cites W2004466604 @default.
- W2109968192 cites W2005085427 @default.
- W2109968192 cites W2006181851 @default.
- W2109968192 cites W2006731736 @default.
- W2109968192 cites W2007112907 @default.
- W2109968192 cites W2010978499 @default.
- W2109968192 cites W2012051499 @default.
- W2109968192 cites W2019596459 @default.
- W2109968192 cites W2026159192 @default.
- W2109968192 cites W2026399893 @default.
- W2109968192 cites W2028826148 @default.
- W2109968192 cites W2030039832 @default.
- W2109968192 cites W2031564767 @default.
- W2109968192 cites W2032347230 @default.
- W2109968192 cites W2033615349 @default.
- W2109968192 cites W2036811613 @default.
- W2109968192 cites W2036957570 @default.
- W2109968192 cites W2042027627 @default.
- W2109968192 cites W2046312135 @default.
- W2109968192 cites W2046659774 @default.
- W2109968192 cites W2050515508 @default.
- W2109968192 cites W2052260458 @default.
- W2109968192 cites W2058077771 @default.
- W2109968192 cites W2060886633 @default.
- W2109968192 cites W2061360674 @default.
- W2109968192 cites W2062199598 @default.
- W2109968192 cites W2064364735 @default.
- W2109968192 cites W2064465184 @default.
- W2109968192 cites W2066126429 @default.
- W2109968192 cites W2069640298 @default.
- W2109968192 cites W2070730552 @default.
- W2109968192 cites W2071602855 @default.
- W2109968192 cites W2071760825 @default.
- W2109968192 cites W2072701419 @default.
- W2109968192 cites W2076843879 @default.
- W2109968192 cites W2076985335 @default.
- W2109968192 cites W2079041375 @default.
- W2109968192 cites W2086506486 @default.
- W2109968192 cites W2087800663 @default.
- W2109968192 cites W2088929333 @default.
- W2109968192 cites W2089813881 @default.
- W2109968192 cites W2093786048 @default.
- W2109968192 cites W2096101576 @default.
- W2109968192 cites W2097487672 @default.
- W2109968192 cites W2098808278 @default.
- W2109968192 cites W2099943242 @default.
- W2109968192 cites W2104402249 @default.
- W2109968192 cites W2105541158 @default.
- W2109968192 cites W2105786988 @default.
- W2109968192 cites W2114488753 @default.
- W2109968192 cites W2120039250 @default.
- W2109968192 cites W2124872226 @default.
- W2109968192 cites W2125883410 @default.
- W2109968192 cites W2126160758 @default.
- W2109968192 cites W2132407886 @default.
- W2109968192 cites W2132493934 @default.
- W2109968192 cites W2134391210 @default.
- W2109968192 cites W2135354390 @default.
- W2109968192 cites W2139115877 @default.
- W2109968192 cites W2139124533 @default.
- W2109968192 cites W2139774608 @default.
- W2109968192 cites W2142815242 @default.
- W2109968192 cites W2143279007 @default.
- W2109968192 cites W2150339415 @default.
- W2109968192 cites W2152210500 @default.
- W2109968192 cites W2152616986 @default.