Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109979513> ?p ?o ?g. }
- W2109979513 endingPage "6" @default.
- W2109979513 startingPage "1792" @default.
- W2109979513 abstract "Unlike quadrupeds, human limbs are exposed to differing homeostatic challenges and uses. The arms are not exposed to a large hydrostatic pressure and contain a relatively small muscle mass that is not typically engaged in heavy work. In contrast, the legs have a large blood volume, experience significant hydrostatic pressures, and contain the majority of the body's muscle mass, which is used regularly to perform the significant work of locomotion. This raises the question of whether skeletal muscle blood flow and metabolism differ between limbs and whether these responses may be altered during exercise as a consequence of aging and disease. Initially, we examine the long standing question of how the body copes with the involvement of both sets of limbs and the large muscle mass that this entails, restrained by a finite cardiac output and a need to defend arterial blood pressure. We therefore evaluate the similarities and differences in exercising muscle blood-flow control in the upper and lower limbs, with respect to exercise onset kinetics, intrinsic vasoreactivity of the resistance vessels at rest and during exercise, and the role of gender and the aging process in limb-specific responses. It is concluded that blood flow and pressure when multiple limbs are simultaneously recruited is facilitated by sympathetically mediated vasoconstriction. Inherent limb differences, in terms of skeletal muscle metabolism and blood flow, do exist, and elucidating the mechanisms underlying limb-specific adaptations will be important for interpreting abnormal vascular function attributable to healthy aging and disease." @default.
- W2109979513 created "2016-06-24" @default.
- W2109979513 creator A5010905666 @default.
- W2109979513 creator A5012498864 @default.
- W2109979513 creator A5016791114 @default.
- W2109979513 creator A5041482139 @default.
- W2109979513 creator A5050361725 @default.
- W2109979513 date "2006-10-01" @default.
- W2109979513 modified "2023-10-17" @default.
- W2109979513 title "Metabolic and vascular limb differences affected by exercise, gender, age, and disease." @default.
- W2109979513 cites W1494105696 @default.
- W2109979513 cites W155647363 @default.
- W2109979513 cites W1576075579 @default.
- W2109979513 cites W1915125682 @default.
- W2109979513 cites W1966210022 @default.
- W2109979513 cites W1981198446 @default.
- W2109979513 cites W1990402349 @default.
- W2109979513 cites W2005265924 @default.
- W2109979513 cites W2005362445 @default.
- W2109979513 cites W2010968782 @default.
- W2109979513 cites W2013782500 @default.
- W2109979513 cites W2024048033 @default.
- W2109979513 cites W2038802970 @default.
- W2109979513 cites W2054082318 @default.
- W2109979513 cites W2063506869 @default.
- W2109979513 cites W2069057073 @default.
- W2109979513 cites W2078181707 @default.
- W2109979513 cites W2080471016 @default.
- W2109979513 cites W2083248715 @default.
- W2109979513 cites W2086436006 @default.
- W2109979513 cites W2112745765 @default.
- W2109979513 cites W2119122478 @default.
- W2109979513 cites W2128533752 @default.
- W2109979513 cites W2130389033 @default.
- W2109979513 cites W2142037089 @default.
- W2109979513 cites W2144096901 @default.
- W2109979513 cites W2145200932 @default.
- W2109979513 cites W2147196253 @default.
- W2109979513 cites W2150047734 @default.
- W2109979513 cites W2154935429 @default.
- W2109979513 cites W2160883632 @default.
- W2109979513 cites W2165351825 @default.
- W2109979513 cites W2166068914 @default.
- W2109979513 cites W2170068045 @default.
- W2109979513 cites W2172918369 @default.
- W2109979513 cites W2340785179 @default.
- W2109979513 cites W2414312700 @default.
- W2109979513 cites W4239959618 @default.
- W2109979513 doi "https://doi.org/10.1249/01.mss.0000229568.17284.ab" @default.
- W2109979513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17019301" @default.
- W2109979513 hasPublicationYear "2006" @default.
- W2109979513 type Work @default.
- W2109979513 sameAs 2109979513 @default.
- W2109979513 citedByCount "110" @default.
- W2109979513 countsByYear W21099795132012 @default.
- W2109979513 countsByYear W21099795132013 @default.
- W2109979513 countsByYear W21099795132014 @default.
- W2109979513 countsByYear W21099795132015 @default.
- W2109979513 countsByYear W21099795132016 @default.
- W2109979513 countsByYear W21099795132017 @default.
- W2109979513 countsByYear W21099795132018 @default.
- W2109979513 countsByYear W21099795132019 @default.
- W2109979513 countsByYear W21099795132020 @default.
- W2109979513 countsByYear W21099795132021 @default.
- W2109979513 countsByYear W21099795132022 @default.
- W2109979513 countsByYear W21099795132023 @default.
- W2109979513 crossrefType "journal-article" @default.
- W2109979513 hasAuthorship W2109979513A5010905666 @default.
- W2109979513 hasAuthorship W2109979513A5012498864 @default.
- W2109979513 hasAuthorship W2109979513A5016791114 @default.
- W2109979513 hasAuthorship W2109979513A5041482139 @default.
- W2109979513 hasAuthorship W2109979513A5050361725 @default.
- W2109979513 hasBestOaLocation W21099795131 @default.
- W2109979513 hasConcept C105702510 @default.
- W2109979513 hasConcept C121332964 @default.
- W2109979513 hasConcept C126322002 @default.
- W2109979513 hasConcept C158846371 @default.
- W2109979513 hasConcept C164705383 @default.
- W2109979513 hasConcept C178853913 @default.
- W2109979513 hasConcept C2779134260 @default.
- W2109979513 hasConcept C2779959927 @default.
- W2109979513 hasConcept C2779961880 @default.
- W2109979513 hasConcept C2910081258 @default.
- W2109979513 hasConcept C42407357 @default.
- W2109979513 hasConcept C63645605 @default.
- W2109979513 hasConcept C71924100 @default.
- W2109979513 hasConcept C84393581 @default.
- W2109979513 hasConcept C97355855 @default.
- W2109979513 hasConcept C99508421 @default.
- W2109979513 hasConceptScore W2109979513C105702510 @default.
- W2109979513 hasConceptScore W2109979513C121332964 @default.
- W2109979513 hasConceptScore W2109979513C126322002 @default.
- W2109979513 hasConceptScore W2109979513C158846371 @default.
- W2109979513 hasConceptScore W2109979513C164705383 @default.
- W2109979513 hasConceptScore W2109979513C178853913 @default.
- W2109979513 hasConceptScore W2109979513C2779134260 @default.
- W2109979513 hasConceptScore W2109979513C2779959927 @default.
- W2109979513 hasConceptScore W2109979513C2779961880 @default.