FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109986875> ?p ?o ?g. }

• W2109986875 endingPage "9692" @default.
• W2109986875 startingPage "9682" @default.
• W2109986875 abstract "Clear cell renal cell carcinoma (RCC) is the most common and invasive adult kidney cancer. The genetic and biological mechanisms that drive metastatic spread of RCC remain largely unknown. We have investigated the molecular signatures and underlying genomic aberrations associated with RCC metastasis, using an approach that combines a human xenograft model; expression profiling of RNA, DNA, and microRNA (miRNA); functional verification; and clinical validation. We show that increased metastatic activity is associated with acquisition of a myofibroblast-like signature in both tumor cell lines and in metastatic tumor biopsies. Our results also show that the mesenchymal trait did not provide an invasive advantage to the metastatic tumor cells. We further show that some of the constituents of the mesenchymal signature, including the expression of the well-characterized myofibroblastic marker S100A4, are functionally relevant. Epigenetic silencing and miRNA-induced expression changes accounted for the change in expression of a significant number of genes, including S100A4, in the myofibroblastic signature; however, DNA copy number variation did not affect the same set of genes. These findings provide evidence that widespread genetic and epigenetic alterations can lead directly to global deregulation of gene expression and contribute to the development or progression of RCC metastasis culminating in a highly malignant myofibroblast-like cell." @default.
• W2109986875 created "2016-06-24" @default.
• W2109986875 creator A5005195883 @default.
• W2109986875 creator A5008057213 @default.
• W2109986875 creator A5009190675 @default.
• W2109986875 creator A5010536553 @default.
• W2109986875 creator A5025018584 @default.
• W2109986875 creator A5028091992 @default.
• W2109986875 creator A5030209609 @default.
• W2109986875 creator A5059063118 @default.
• W2109986875 creator A5080223712 @default.
• W2109986875 date "2010-12-01" @default.
• W2109986875 modified "2023-10-17" @default.
• W2109986875 title "Genomic Deregulation during Metastasis of Renal Cell Carcinoma Implements a Myofibroblast-Like Program of Gene Expression" @default.
• W2109986875 cites W1966807349 @default.
• W2109986875 cites W1969696386 @default.
• W2109986875 cites W1971980067 @default.
• W2109986875 cites W1974747095 @default.
• W2109986875 cites W1984477411 @default.
• W2109986875 cites W1986471913 @default.
• W2109986875 cites W1989491973 @default.
• W2109986875 cites W1998096683 @default.
• W2109986875 cites W1998811052 @default.
• W2109986875 cites W2012247886 @default.
• W2109986875 cites W2013826368 @default.
• W2109986875 cites W2017373399 @default.
• W2109986875 cites W2017946623 @default.
• W2109986875 cites W2023290310 @default.
• W2109986875 cites W2029940868 @default.
• W2109986875 cites W2037733084 @default.
• W2109986875 cites W2048005397 @default.
• W2109986875 cites W2049820772 @default.
• W2109986875 cites W2057151160 @default.
• W2109986875 cites W2057841149 @default.
• W2109986875 cites W2062249523 @default.
• W2109986875 cites W2062809449 @default.
• W2109986875 cites W2063011414 @default.
• W2109986875 cites W2064450320 @default.
• W2109986875 cites W2076310052 @default.
• W2109986875 cites W2076356585 @default.
• W2109986875 cites W2076670908 @default.
• W2109986875 cites W2082331198 @default.
• W2109986875 cites W2082833890 @default.
• W2109986875 cites W2086064946 @default.
• W2109986875 cites W2089370460 @default.
• W2109986875 cites W2092868756 @default.
• W2109986875 cites W2101037339 @default.
• W2109986875 cites W2104416279 @default.
• W2109986875 cites W2104778949 @default.
• W2109986875 cites W2108296770 @default.
• W2109986875 cites W2110666579 @default.
• W2109986875 cites W2111156691 @default.
• W2109986875 cites W2122669251 @default.
• W2109986875 cites W2141815918 @default.
• W2109986875 cites W2149456801 @default.
• W2109986875 cites W2150536104 @default.
• W2109986875 cites W2154361640 @default.
• W2109986875 cites W2156038562 @default.
• W2109986875 cites W2156927848 @default.
• W2109986875 cites W4244774747 @default.
• W2109986875 doi "https://doi.org/10.1158/0008-5472.can-10-2279" @default.
• W2109986875 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3281492" @default.
• W2109986875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20952505" @default.
• W2109986875 hasPublicationYear "2010" @default.
• W2109986875 type Work @default.
• W2109986875 sameAs 2109986875 @default.
• W2109986875 citedByCount "31" @default.
• W2109986875 countsByYear W21099868752012 @default.
• W2109986875 countsByYear W21099868752013 @default.
• W2109986875 countsByYear W21099868752014 @default.
• W2109986875 countsByYear W21099868752015 @default.
• W2109986875 countsByYear W21099868752017 @default.
• W2109986875 countsByYear W21099868752019 @default.
• W2109986875 countsByYear W21099868752020 @default.
• W2109986875 countsByYear W21099868752021 @default.
• W2109986875 countsByYear W21099868752022 @default.
• W2109986875 countsByYear W21099868752023 @default.
• W2109986875 crossrefType "journal-article" @default.
• W2109986875 hasAuthorship W2109986875A5005195883 @default.
• W2109986875 hasAuthorship W2109986875A5008057213 @default.
• W2109986875 hasAuthorship W2109986875A5009190675 @default.
• W2109986875 hasAuthorship W2109986875A5010536553 @default.
• W2109986875 hasAuthorship W2109986875A5025018584 @default.
• W2109986875 hasAuthorship W2109986875A5028091992 @default.
• W2109986875 hasAuthorship W2109986875A5030209609 @default.
• W2109986875 hasAuthorship W2109986875A5059063118 @default.
• W2109986875 hasAuthorship W2109986875A5080223712 @default.
• W2109986875 hasBestOaLocation W21099868751 @default.
• W2109986875 hasConcept C104317684 @default.
• W2109986875 hasConcept C119056186 @default.
• W2109986875 hasConcept C121608353 @default.
• W2109986875 hasConcept C142724271 @default.
• W2109986875 hasConcept C145059251 @default.
• W2109986875 hasConcept C150194340 @default.
• W2109986875 hasConcept C18431079 @default.
• W2109986875 hasConcept C190727270 @default.
• W2109986875 hasConcept C198826908 @default.
• W2109986875 hasConcept C2777472916 @default.

• next