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• W2109997715 abstract "The HIV pandemic has posed an unprecedented challenge to the global health, devastating communities and reinforcing the historical problems that link ill-health with poverty. Sound evidence for public health decision-making is needed as antiretroviral programmes are being rolled out in developing countries. This thesis discusses the effectiveness of Highly Active Antiretroviral Therapy (HAART) in resource-limited countries from the Antiretroviral Therapy in Lower Income Countries (ART-LINC), a network of HIV/AIDS treatment programmes and cohorts in Africa, South America, and Asia. The objectives of this project were to document the effectiveness of HAART in these settings, defined by changes in immunologic and virologic markers within 6 months of treatment; assess factors associated with 6-month response to therapy; and to assess the association of 6 month response with long-term outcomes.In the first article, the evidence supporting effectiveness of HAART is reviewed, focusing on aspects of immunologic and virologic responses to therapy. Despite the lack of a standardized definition of immunologic and virologic response, we conclude that around one third of the patients who start HAART show a response pattern where either immunologic or virologic response is not achieved, a condition referred to as discordant response. The second and third articles provide a picture of the association between HAART and 6-month response in resource-limited countries. Overall, the effectiveness of HAART in these settings is similar to that reported in resource-rich countries. Finally, we assessed the association between immunologic and virologic discordant responses at 6 months and mortality in ART-LINC. We found that the hazard of death for those showing discordance at 6 months was similar to that reported in resource-rich countries. However, we found that early mortality was high in Africa and Asia, and a significant proportion of patients that did not have access to laboratory measurements were also at greater risk of death. This is the first report on the association of discordant responses and mortality in lower income countries, which provides important evidence for public health decision making in the context of antiretroviral rollout." @default.
• W2109997715 created "2016-06-24" @default.
• W2109997715 creator A5049885834 @default.
• W2109997715 date "2008-06-23" @default.
• W2109997715 modified "2023-09-27" @default.
• W2109997715 title "Effectiveness of Highly Active Antiretroviral Therapy in HIV patients in resource-limited settings" @default.
• W2109997715 cites W148835879 @default.
• W2109997715 cites W1690495699 @default.
• W2109997715 cites W1735143085 @default.
• W2109997715 cites W1951712651 @default.
• W2109997715 cites W1964622370 @default.
• W2109997715 cites W1965538807 @default.
• W2109997715 cites W1966413994 @default.
• W2109997715 cites W1967223378 @default.
• W2109997715 cites W1968454378 @default.
• W2109997715 cites W1968938233 @default.
• W2109997715 cites W1970713740 @default.
• W2109997715 cites W1977586561 @default.
• W2109997715 cites W1979721624 @default.
• W2109997715 cites W1983537547 @default.
• W2109997715 cites W1984814658 @default.
• W2109997715 cites W1986574361 @default.
• W2109997715 cites W1989244400 @default.
• W2109997715 cites W1991312833 @default.
• W2109997715 cites W1993443901 @default.
• W2109997715 cites W1994745669 @default.
• W2109997715 cites W1995955039 @default.
• W2109997715 cites W1996168633 @default.
• W2109997715 cites W1998182540 @default.
• W2109997715 cites W2003199949 @default.
• W2109997715 cites W2004293828 @default.
• W2109997715 cites W2007021820 @default.
• W2109997715 cites W2008382587 @default.
• W2109997715 cites W2011529667 @default.
• W2109997715 cites W2012176284 @default.
• W2109997715 cites W2013788600 @default.
• W2109997715 cites W2014140728 @default.
• W2109997715 cites W2014572186 @default.
• W2109997715 cites W2015058246 @default.
• W2109997715 cites W2016821019 @default.
• W2109997715 cites W2017793579 @default.
• W2109997715 cites W2018551422 @default.
• W2109997715 cites W2027974789 @default.
• W2109997715 cites W2033820520 @default.
• W2109997715 cites W2047925489 @default.
• W2109997715 cites W2049863380 @default.
• W2109997715 cites W2052147049 @default.
• W2109997715 cites W2055893327 @default.
• W2109997715 cites W2056118379 @default.
• W2109997715 cites W2057504223 @default.
• W2109997715 cites W2057578063 @default.
• W2109997715 cites W2058117818 @default.
• W2109997715 cites W2060291287 @default.
• W2109997715 cites W2060382789 @default.
• W2109997715 cites W2061682103 @default.
• W2109997715 cites W2062703620 @default.
• W2109997715 cites W2065180342 @default.
• W2109997715 cites W2067327444 @default.
• W2109997715 cites W2067950821 @default.
• W2109997715 cites W2068085580 @default.
• W2109997715 cites W2069988176 @default.
• W2109997715 cites W2070487350 @default.
• W2109997715 cites W2071226541 @default.
• W2109997715 cites W2077712940 @default.
• W2109997715 cites W2078978810 @default.
• W2109997715 cites W2080660922 @default.
• W2109997715 cites W2081198205 @default.
• W2109997715 cites W2083425994 @default.
• W2109997715 cites W2083754882 @default.
• W2109997715 cites W2086398212 @default.
• W2109997715 cites W2098938825 @default.
• W2109997715 cites W2103866977 @default.
• W2109997715 cites W2104489459 @default.
• W2109997715 cites W2106164053 @default.
• W2109997715 cites W2108532941 @default.
• W2109997715 cites W2111980395 @default.
• W2109997715 cites W2116258000 @default.
• W2109997715 cites W2118502261 @default.
• W2109997715 cites W2120721032 @default.
• W2109997715 cites W2121118810 @default.
• W2109997715 cites W2122280827 @default.
• W2109997715 cites W2124178178 @default.
• W2109997715 cites W2131403498 @default.
• W2109997715 cites W2133011527 @default.
• W2109997715 cites W2133164790 @default.
• W2109997715 cites W2137262613 @default.
• W2109997715 cites W2137523454 @default.
• W2109997715 cites W2144840425 @default.
• W2109997715 cites W2148137618 @default.
• W2109997715 cites W2150484278 @default.
• W2109997715 cites W2152276635 @default.
• W2109997715 cites W2155449170 @default.
• W2109997715 cites W2156330207 @default.
• W2109997715 cites W2159287402 @default.
• W2109997715 cites W2159578627 @default.
• W2109997715 cites W2164350100 @default.
• W2109997715 cites W2164788271 @default.
• W2109997715 cites W2171141994 @default.
• W2109997715 cites W2171852434 @default.
• W2109997715 cites W2172274075 @default.

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