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- W2110014634 abstract "Some interneurons of the hippocampus exhibit NMDA receptor-independent long-term potentiation (LTP) that is induced by presynaptic glutamate release when the postsynaptic membrane potential is hyperpolarized. This anti-Hebbian form of LTP is prevented by postsynaptic depolarization or by blocking AMPA and kainate receptors. Although both AMPA and kainate receptors are expressed in hippocampal interneurons, their relative roles in anti-Hebbian LTP are not known. Because interneuron diversity potentially conceals simple rules underlying different forms of plasticity, we focus on glutamatergic synapses onto a subset of interneurons with dendrites in stratum oriens and a main ascending axon that projects to stratum lacunosum moleculare, the oriens-lacunosum moleculare (O-LM) cells. We show that anti-Hebbian LTP in O-LM interneurons has consistent induction and expression properties, and is prevented by selective inhibition of AMPA receptors. The majority of the ionotropic glutamatergic synaptic current in these cells is mediated by inwardly rectifying Ca(2+)-permeable AMPA receptors. Although GluR5-containing kainate receptors contribute to synaptic currents at high stimulus frequency, they are not required for LTP induction. Glutamatergic synapses on O-LM cells thus behave in a homogeneous manner and exhibit LTP dependent on Ca(2+)-permeable AMPA receptors." @default.
- W2110014634 created "2016-06-24" @default.
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- W2110014634 creator A5085974313 @default.
- W2110014634 date "2009-01-28" @default.
- W2110014634 modified "2023-10-01" @default.
- W2110014634 title "Role of Ionotropic Glutamate Receptors in Long-Term Potentiation in Rat Hippocampal CA1 Oriens-Lacunosum Moleculare Interneurons" @default.
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- W2110014634 doi "https://doi.org/10.1523/jneurosci.3251-08.2009" @default.
- W2110014634 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2668821" @default.
- W2110014634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19176803" @default.
- W2110014634 hasPublicationYear "2009" @default.
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