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- W2110018116 startingPage "2013" @default.
- W2110018116 abstract "In the current era of massive discoveries of noncoding RNAs within genomes, being able to infer a function from a nucleotide sequence is of paramount interest. Although studies of individual group I introns have identified self-splicing and nonself-splicing examples, there is no overall understanding of the prevalence of self-splicing or the factors that determine it among the >2300 group I introns sequenced to date. Here, the self-splicing activities of 12 group I introns from various organisms were assayed under six reaction conditions that had been shown previously to promote RNA catalysis for different RNAs. Besides revealing that assessing self-splicing under only one condition can be misleading, this survey emphasizes that in vitro self-splicing efficiency is correlated with the GC content of the intron (>35% GC was generally conductive to self-splicing), and with the ability of the introns to form particular tertiary interactions. Addition of the Neurospora crassa CYT-18 protein activated splicing of two nonself-splicing introns, but inhibited the second step of self-splicing for two others. Together, correlations between sequence, predicted structure and splicing begin to establish rules that should facilitate our ability to predict the self-splicing activity of any group I intron from its sequence." @default.
- W2110018116 created "2016-06-24" @default.
- W2110018116 creator A5005988075 @default.
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- W2110018116 creator A5018416560 @default.
- W2110018116 creator A5066896437 @default.
- W2110018116 creator A5088646770 @default.
- W2110018116 date "2008-09-03" @default.
- W2110018116 modified "2023-10-12" @default.
- W2110018116 title "Toward predicting self-splicing and protein-facilitated splicing of group I introns" @default.
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- W2110018116 doi "https://doi.org/10.1261/rna.1027208" @default.
- W2110018116 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2553746" @default.
- W2110018116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18768647" @default.
- W2110018116 hasPublicationYear "2008" @default.
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