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• W2110034080 abstract "In a preliminary screen, Aaptos aaptos showed significant cytotoxic activity towards a panel of cell lines and was thus subjected to bioassay-guided isolation of the bioactive constituents. In addition to the known aaptamine, two new derivatives of the alkaloid were isolated from the bioactive chloroform fraction of the crude methanolic extract. Detailed analysis by NMR and mass spectroscopy enabled their identification to be 3-(phenethylamino)demethyl(oxy)aaptamine and 3-(isopentylamino)demethyl(oxy) aaptamine. The cytotoxic activities of the three alkaloids were further evaluated against CEM-SS cells." @default.
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• W2110034080 date "2008-12-28" @default.
• W2110034080 modified "2023-10-10" @default.
• W2110034080 title "Cytotoxic Aaptamines from Malaysian Aaptos aaptos" @default.
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• W2110034080 doi "https://doi.org/10.3390/md7010001" @default.
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