Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110051910> ?p ?o ?g. }
- W2110051910 endingPage "5634" @default.
- W2110051910 startingPage "5626" @default.
- W2110051910 abstract "Abstract Although previous studies have investigated the role of IL-27/WSX-1 interactions in the regulation of Th1 responses, little is known about their role in regulating Th2-type responses. Studies presented in this work identify a direct role for IL-27/WSX-1 interactions in the negative regulation of type 2 responses independent of effects on type 1 cytokines. WSX-1−/− mice infected with the gastrointestinal helminth Trichuris muris displayed accelerated expulsion of parasites and the development of exaggerated goblet cell hyperplasia and mastocytosis in the gut due to increased production of Th2 cytokines. Enhanced mast cell activity in the absence of WSX-1 was consistent with the ability of wild-type mast cells to express this receptor. In addition, IL-27 directly suppressed CD4+ T cell proliferation and Th2 cytokine production. Together, these studies identify a novel role for IL-27/WSX-1 in limiting innate and adaptive components of type 2 immunity at mucosal sites." @default.
- W2110051910 created "2016-06-24" @default.
- W2110051910 creator A5003951398 @default.
- W2110051910 creator A5005500510 @default.
- W2110051910 creator A5032759284 @default.
- W2110051910 creator A5038240598 @default.
- W2110051910 creator A5041373467 @default.
- W2110051910 creator A5046136308 @default.
- W2110051910 creator A5051654875 @default.
- W2110051910 creator A5057601321 @default.
- W2110051910 creator A5062220434 @default.
- W2110051910 creator A5073662417 @default.
- W2110051910 creator A5074408444 @default.
- W2110051910 creator A5075407171 @default.
- W2110051910 creator A5076621472 @default.
- W2110051910 creator A5076944041 @default.
- W2110051910 creator A5081963933 @default.
- W2110051910 creator A5085466879 @default.
- W2110051910 creator A5087757302 @default.
- W2110051910 creator A5088646837 @default.
- W2110051910 date "2004-11-01" @default.
- W2110051910 modified "2023-10-15" @default.
- W2110051910 title "The IL-27 Receptor (WSX-1) Is an Inhibitor of Innate and Adaptive Elements of Type 2 Immunity" @default.
- W2110051910 cites W1530794261 @default.
- W2110051910 cites W1532354797 @default.
- W2110051910 cites W1540487906 @default.
- W2110051910 cites W1567392757 @default.
- W2110051910 cites W1671465655 @default.
- W2110051910 cites W1947436130 @default.
- W2110051910 cites W1964909764 @default.
- W2110051910 cites W1968918322 @default.
- W2110051910 cites W1986370046 @default.
- W2110051910 cites W2003182569 @default.
- W2110051910 cites W2009219530 @default.
- W2110051910 cites W2012198462 @default.
- W2110051910 cites W2016956768 @default.
- W2110051910 cites W2022669535 @default.
- W2110051910 cites W2057522151 @default.
- W2110051910 cites W2059079830 @default.
- W2110051910 cites W2065601509 @default.
- W2110051910 cites W2065708991 @default.
- W2110051910 cites W2070542693 @default.
- W2110051910 cites W2073242835 @default.
- W2110051910 cites W2077865652 @default.
- W2110051910 cites W2079077285 @default.
- W2110051910 cites W2084150021 @default.
- W2110051910 cites W2089262366 @default.
- W2110051910 cites W2090831287 @default.
- W2110051910 cites W2091301099 @default.
- W2110051910 cites W2097762449 @default.
- W2110051910 cites W2101795973 @default.
- W2110051910 cites W2111980183 @default.
- W2110051910 cites W2119120508 @default.
- W2110051910 cites W2119986617 @default.
- W2110051910 cites W2123669456 @default.
- W2110051910 cites W2125415295 @default.
- W2110051910 cites W2129292145 @default.
- W2110051910 cites W2139725558 @default.
- W2110051910 cites W2141429703 @default.
- W2110051910 cites W2143290550 @default.
- W2110051910 cites W2146234274 @default.
- W2110051910 cites W2148996267 @default.
- W2110051910 cites W2154750376 @default.
- W2110051910 cites W2156788680 @default.
- W2110051910 cites W2162319187 @default.
- W2110051910 cites W2164950536 @default.
- W2110051910 cites W2170944561 @default.
- W2110051910 cites W2176043086 @default.
- W2110051910 cites W2886978647 @default.
- W2110051910 doi "https://doi.org/10.4049/jimmunol.173.9.5626" @default.
- W2110051910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15494513" @default.
- W2110051910 hasPublicationYear "2004" @default.
- W2110051910 type Work @default.
- W2110051910 sameAs 2110051910 @default.
- W2110051910 citedByCount "225" @default.
- W2110051910 countsByYear W21100519102012 @default.
- W2110051910 countsByYear W21100519102013 @default.
- W2110051910 countsByYear W21100519102014 @default.
- W2110051910 countsByYear W21100519102015 @default.
- W2110051910 countsByYear W21100519102016 @default.
- W2110051910 countsByYear W21100519102017 @default.
- W2110051910 countsByYear W21100519102018 @default.
- W2110051910 countsByYear W21100519102019 @default.
- W2110051910 countsByYear W21100519102020 @default.
- W2110051910 countsByYear W21100519102021 @default.
- W2110051910 countsByYear W21100519102022 @default.
- W2110051910 countsByYear W21100519102023 @default.
- W2110051910 crossrefType "journal-article" @default.
- W2110051910 hasAuthorship W2110051910A5003951398 @default.
- W2110051910 hasAuthorship W2110051910A5005500510 @default.
- W2110051910 hasAuthorship W2110051910A5032759284 @default.
- W2110051910 hasAuthorship W2110051910A5038240598 @default.
- W2110051910 hasAuthorship W2110051910A5041373467 @default.
- W2110051910 hasAuthorship W2110051910A5046136308 @default.
- W2110051910 hasAuthorship W2110051910A5051654875 @default.
- W2110051910 hasAuthorship W2110051910A5057601321 @default.
- W2110051910 hasAuthorship W2110051910A5062220434 @default.
- W2110051910 hasAuthorship W2110051910A5073662417 @default.