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- W2110069436 abstract "While nature employs various covalent and non-covalent strategies to modulate tyrosine (Y) redox potential and pKa in order to optimize enzyme activities, such approaches have not been systematically applied for the design of functional metalloproteins. Through the genetic incorporation of 3-methoxytyrosine (OMeY) into myoglobin, we replicated important features of cytochrome c oxidase (CcO) in this small soluble protein, which exhibits selective O2 reduction activity while generating a small amount of reactive oxygen species (ROS). These results demonstrate that the electron donating ability of a tyrosine residue in the active site is important for CcO function. Moreover, we elucidated the structural basis for the genetic incorporation of OMeY into proteins by solving the X-ray structure of OMeY specific aminoacyl-tRNA synthetase complexed with OMeY." @default.
- W2110069436 created "2016-06-24" @default.
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- W2110069436 date "2015-01-01" @default.
- W2110069436 modified "2023-10-10" @default.
- W2110069436 title "Significant improvement of oxidase activity through the genetic incorporation of a redox-active unnatural amino acid" @default.
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- W2110069436 doi "https://doi.org/10.1039/c5sc01126d" @default.
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