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• W2110072912 abstract "Abstract Background The diagnostic accuracy of multidetector computed tomography ( MDCT ) in the detection of left atrial/left atrial appendage ( LA / LAA ) thrombus had been tested in many studies; however, the results are controversial. Aim The aim of the present study was to evaluate synthetically the diagnostic accuracy of MDCT in LA / LAA thrombus. Methods PubMed and E mbase were searched for published prospective studies which compared computed tomography with transoesophageal echocardiography ( TEE ) in detecting LA / LAA thrombus prior to M arch 2014. Descriptive and quantitative information was extracted and M eta DiS c 1.4 was used to perform a meta‐analysis. Results Fifteen prospective clinical controlled trials with 2540 patients fulfilled the inclusion criteria. The pooled sensitivities ( SEN ): 0.957; pooled specificities ( SPE ): 0.917; pooled positive likelihood ratio ( PLR ): 22.017; pooled negative likelihood ratio ( NLR ): 0.060; pooled diagnostic odds ratio ( DOR ): 437.43; the area under the curve ( AUC ): 0.9883; Q *‐value: 0.9544. However, in the abovementioned indexes, the heterogeneities were statistically significant between studies ( P < 0.05, inconsistency index ( I 2 ) > 50%). In a sub‐analysis of studies in which delayed imaging, electrocardiogram ( ECG ) gating and heart rate control were performed, not only the diagnostic accuracy, but also the heterogeneities were significantly improved (pooled SEN 0.991; pooled SPE 0.989; pooled PLR 60.768; pooled NLR 0.034; pooled DOR 2561.7; AUC 0.9972; Q *‐value 0.9806; all the indexes' P ‐value were greater than 0.05 and the I 2 were 0%, except for SPE , I 2 = 54.6%). Conclusion For patients with TEE intolerance or contraindications, MDCT may be an alternative method, especially when the delayed imaging, ECG gating and heart rate control were performed." @default.
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• W2110072912 date "2015-10-01" @default.
• W2110072912 modified "2023-09-27" @default.
• W2110072912 title "Multidetector computed tomography for detecting left atrial/left atrial appendage thrombus: a meta-analysis" @default.
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• W2110072912 doi "https://doi.org/10.1111/imj.12862" @default.
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