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• W2110097921 endingPage "7086" @default.
• W2110097921 startingPage "7080" @default.
• W2110097921 abstract "ABSTRACT The transactivator protein of human immunodeficiency virus type 1 (HIV-1) (Tat) is a powerful activator of nuclear factor-κB (NF-κB), acting through degradation of the inhibitor IκB-α (F. Demarchi, F. d’Adda di Fagagna, A. Falaschi, and M. Giacca, J. Virol. 70:4427–4437, 1996). Here, we show that this activity of Tat requires the function of the cellular interferon-inducible protein kinase PKR. Tat-mediated NF-κB activation and transcriptional induction of the HIV-1 long terminal repeat were impaired in murine cells in which the PKR gene was knocked out. Both functions were restored by cotransfection of Tat with the cDNA for PKR. Expression of a dominant-negative mutant of PKR specifically reduced the levels of Tat transactivation in different human cell types. Activation of NF-κB by Tat required integrity of the basic domain of Tat; previous studies have indicated that this domain is necessary for specific Tat-PKR interaction." @default.
• W2110097921 created "2016-06-24" @default.
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• W2110097921 date "1999-08-01" @default.
• W2110097921 modified "2023-10-17" @default.
• W2110097921 title "Human Immunodeficiency Virus Type 1 Tat Protein Activates Transcription Factor NF-κB through the Cellular Interferon-Inducible, Double-Stranded RNA-Dependent Protein Kinase, PKR" @default.
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• W2110097921 doi "https://doi.org/10.1128/jvi.73.8.7080-7086.1999" @default.
• W2110097921 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/112801" @default.
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