Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110127639> ?p ?o ?g. }
- W2110127639 endingPage "639" @default.
- W2110127639 startingPage "628" @default.
- W2110127639 abstract "The calcium-sensing receptor (CASR) adjusts the extracellular calcium set point regulating PTH secretion and renal calcium excretion. The receptor is expressed in several tissues and is also involved in other cellular functions such as proliferation, differentiation and other hormonal secretion. High extracellular calcium levels activate the receptor resulting in modulation of several signaling pathways depending on the target tissues. Mutations in the CASR gene can result in gain or loss of receptor function. Gain of function mutations are associated to Autossomal dominant hypocalcemia and Bartter syndrome type V, while loss of function mutations are associated to Familial hypocalciuric hypercalcemia and Neonatal severe hyperparathyroidism. More than one hundred mutations were described in this gene. In addition to calcium, the receptor also interacts with several ions and polyamines. The CASR is a potential therapeutic target to treatment of diseases including hyperparathyroidism and osteoporosis, since its interaction with pharmacological compounds results in modulation of PTH secretion." @default.
- W2110127639 created "2016-06-24" @default.
- W2110127639 creator A5077290368 @default.
- W2110127639 date "2006-08-01" @default.
- W2110127639 modified "2023-10-17" @default.
- W2110127639 title "The calcium-sensing receptor and related diseases" @default.
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