Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110133792> ?p ?o ?g. }
- W2110133792 endingPage "4683" @default.
- W2110133792 startingPage "4673" @default.
- W2110133792 abstract "Chemotherapy is a popular treatment approach against cancer but significant uptake of drugs by normal tissues is still a major limitation. Magnetic drug targeting (MDT) has been used to improve localized drug delivery to interstitial tumor targets. MDT is now being developed to improve drug delivery to tumor vessels. We thus seek to understand the role of magnetite (MAG-C) in drug loading, influence on cytotoxicity and vascular targeting characteristics. The inclusion of MAG-C at lower concentrations (0.5 mg/ml) in cationic liposomes did not alter the efficiency of loading etoposide, but at higher concentrations (2.5 mg/ml) incorporation decreased from 80+/-3.4% to 44+/-4.26%. MAG-C reduced the incorporation of dacarbazine. The incorporation was significantly lower compared to liposomal etoposide, both in the presence and absence of MAG-C. The incorporation efficiency of vinblastine sulfate in cationic liposomes was similar for low and relatively high MAG-C content; values for incorporation were 21+/-0.11 and 23+/-2, respectively. Polyethylene-glycol improved the efficiency of loading chemotherapeutic agents regardless of drug type. Additionally, cytotoxicity and tumor vascular targeting characteristics of liposome therapeutics were not influenced by MAG-C. The components used to prepare magnetic liposomes for MDT should be optimized for maximum therapeutic benefit." @default.
- W2110133792 created "2016-06-24" @default.
- W2110133792 creator A5059312550 @default.
- W2110133792 creator A5085010424 @default.
- W2110133792 date "2007-11-01" @default.
- W2110133792 modified "2023-10-01" @default.
- W2110133792 title "The drug loading, cytotoxicty and tumor vascular targeting characteristics of magnetite in magnetic drug targeting" @default.
- W2110133792 cites W1534320818 @default.
- W2110133792 cites W1556689872 @default.
- W2110133792 cites W1567569917 @default.
- W2110133792 cites W1879616740 @default.
- W2110133792 cites W1968968207 @default.
- W2110133792 cites W1969106834 @default.
- W2110133792 cites W1972767425 @default.
- W2110133792 cites W1975188267 @default.
- W2110133792 cites W1979887297 @default.
- W2110133792 cites W1981350195 @default.
- W2110133792 cites W1981350889 @default.
- W2110133792 cites W1982849219 @default.
- W2110133792 cites W1987252262 @default.
- W2110133792 cites W1987564805 @default.
- W2110133792 cites W1989072027 @default.
- W2110133792 cites W1991443010 @default.
- W2110133792 cites W1996331958 @default.
- W2110133792 cites W2001195833 @default.
- W2110133792 cites W2003841370 @default.
- W2110133792 cites W2012385670 @default.
- W2110133792 cites W2015682585 @default.
- W2110133792 cites W2022322831 @default.
- W2110133792 cites W2023933505 @default.
- W2110133792 cites W2028377738 @default.
- W2110133792 cites W2031823798 @default.
- W2110133792 cites W2032598681 @default.
- W2110133792 cites W2033715508 @default.
- W2110133792 cites W2036811391 @default.
- W2110133792 cites W2040393410 @default.
- W2110133792 cites W2051907464 @default.
- W2110133792 cites W2059619902 @default.
- W2110133792 cites W2060044923 @default.
- W2110133792 cites W2077389173 @default.
- W2110133792 cites W2077572991 @default.
- W2110133792 cites W2081577217 @default.
- W2110133792 cites W2082359208 @default.
- W2110133792 cites W2087924528 @default.
- W2110133792 cites W2090389716 @default.
- W2110133792 cites W2090742333 @default.
- W2110133792 cites W2101758592 @default.
- W2110133792 cites W2102981736 @default.
- W2110133792 cites W2104631267 @default.
- W2110133792 cites W2109689528 @default.
- W2110133792 cites W2111164386 @default.
- W2110133792 cites W2113807798 @default.
- W2110133792 cites W2118878458 @default.
- W2110133792 cites W2120212441 @default.
- W2110133792 cites W2124290300 @default.
- W2110133792 cites W2130176746 @default.
- W2110133792 cites W2131311685 @default.
- W2110133792 cites W2132154923 @default.
- W2110133792 cites W2141670540 @default.
- W2110133792 cites W2150435224 @default.
- W2110133792 cites W2152574565 @default.
- W2110133792 cites W2156587383 @default.
- W2110133792 cites W2163164444 @default.
- W2110133792 cites W2164446172 @default.
- W2110133792 cites W2189088831 @default.
- W2110133792 cites W46714953 @default.
- W2110133792 cites W7317053 @default.
- W2110133792 cites W998955347 @default.
- W2110133792 doi "https://doi.org/10.1016/j.biomaterials.2007.07.024" @default.
- W2110133792 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17688940" @default.
- W2110133792 hasPublicationYear "2007" @default.
- W2110133792 type Work @default.
- W2110133792 sameAs 2110133792 @default.
- W2110133792 citedByCount "101" @default.
- W2110133792 countsByYear W21101337922012 @default.
- W2110133792 countsByYear W21101337922013 @default.
- W2110133792 countsByYear W21101337922014 @default.
- W2110133792 countsByYear W21101337922015 @default.
- W2110133792 countsByYear W21101337922016 @default.
- W2110133792 countsByYear W21101337922017 @default.
- W2110133792 countsByYear W21101337922018 @default.
- W2110133792 countsByYear W21101337922019 @default.
- W2110133792 countsByYear W21101337922021 @default.
- W2110133792 countsByYear W21101337922022 @default.
- W2110133792 countsByYear W21101337922023 @default.
- W2110133792 crossrefType "journal-article" @default.
- W2110133792 hasAuthorship W2110133792A5059312550 @default.
- W2110133792 hasAuthorship W2110133792A5085010424 @default.
- W2110133792 hasConcept C104317684 @default.
- W2110133792 hasConcept C109316439 @default.
- W2110133792 hasConcept C111599444 @default.
- W2110133792 hasConcept C126511603 @default.
- W2110133792 hasConcept C141071460 @default.
- W2110133792 hasConcept C155887181 @default.
- W2110133792 hasConcept C171250308 @default.
- W2110133792 hasConcept C18150654 @default.
- W2110133792 hasConcept C185154212 @default.
- W2110133792 hasConcept C185592680 @default.