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- W2110134562 abstract "Studies were performed to determine whether [18F]6-fluorometaraminol (18F-FMR), a new neuronal heart radiopharmaceutical, is metabolized in vivo and if the metabolites are taken up in heart. Rat, dog, baboon and guinea pig were injected with 18F-FMR and tissue samples were analyzed for metabolites by HPLC. Liver contained the most metabolites of the tissues studied with 25–90% of the radioactivity present as metabolites at 1 h in all the species studied. While metabolites of 18F-FMR are found in blood, no significant accumulation of these metabolites is found in heart (⩽0.3%) 1 h after i.v. administration in any species except rat. These studies suggest that 18F-FMR is a suitable agent for quantitative imaging of the heart by positron emission tomography." @default.
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- W2110134562 date "1989-01-01" @default.
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- W2110134562 title "Metabolic fate of the heart agent [18F]6-fluorometaraminol" @default.
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- W2110134562 doi "https://doi.org/10.1016/0883-2897(89)90147-5" @default.
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