Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110135281> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2110135281 endingPage "254" @default.
- W2110135281 startingPage "249" @default.
- W2110135281 abstract "Cells of the human promyelocytic HL60 line were induced to differentiate into granulocyte-like cells with dimethylsulphoxide (DMSO) or macrophage-like cells with 12-0-tetradecanoylphorbol-13-acetate (TPA). The synthesis of Cathepsin B by these cells was studied by immunoperoxidase staining and assay of cell lysates using the fluorimetric substrate benzoyloxycarbonyl-phenylanalyl-arginine-4-methyl-7-coumarylamide. Only 2–5% of the uninduced HL60 cells and DMSO-induced cells were immunohistochemically positive for Cathepsin B, compared with over 80% of the TPA-induced cells. Cathepsin B activity was lowest in the lysates of uninduced HL60s. DMSO-induced cells contained 1.5–2-fold the enzyme activity of HL60s and TPA-induced cell lysates demonstrated 5–14-fold the activity of uninduced HL60s. Induction of Cathepsin B synthesis was therefore associated with differentiation of the promyelocytes into cells of the monocyte/macrophage type, but not granulocyte-like cells. Cathepsin B was located immunohistochemically in human palatine tonsils. The enzyme was only demonstrated within macrophages in these tissues. Cathepsin B may therefore be a useful immunohistochemical marker for malignant and nonmalignant cells of the monocyte/macrophage lineage." @default.
- W2110135281 created "2016-06-24" @default.
- W2110135281 creator A5010859908 @default.
- W2110135281 creator A5049347564 @default.
- W2110135281 creator A5058668189 @default.
- W2110135281 date "1983-06-01" @default.
- W2110135281 modified "2023-09-27" @default.
- W2110135281 title "Synthesis of cathepsin B by cells derived from the HL60 promyelocytic leukaemia cell line" @default.
- W2110135281 cites W1963507214 @default.
- W2110135281 cites W1967034103 @default.
- W2110135281 cites W1968028322 @default.
- W2110135281 cites W1989367789 @default.
- W2110135281 cites W2014520088 @default.
- W2110135281 cites W2024848115 @default.
- W2110135281 cites W2054276868 @default.
- W2110135281 cites W2058224522 @default.
- W2110135281 cites W2058787250 @default.
- W2110135281 cites W2062124441 @default.
- W2110135281 cites W20915926 @default.
- W2110135281 cites W2125376694 @default.
- W2110135281 cites W2137264529 @default.
- W2110135281 cites W2139175584 @default.
- W2110135281 cites W2161173372 @default.
- W2110135281 cites W2164821085 @default.
- W2110135281 cites W2344360060 @default.
- W2110135281 cites W2424552696 @default.
- W2110135281 doi "https://doi.org/10.1002/jcp.1041150306" @default.
- W2110135281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6343405" @default.
- W2110135281 hasPublicationYear "1983" @default.
- W2110135281 type Work @default.
- W2110135281 sameAs 2110135281 @default.
- W2110135281 citedByCount "33" @default.
- W2110135281 countsByYear W21101352812013 @default.
- W2110135281 countsByYear W21101352812016 @default.
- W2110135281 countsByYear W21101352812021 @default.
- W2110135281 crossrefType "journal-article" @default.
- W2110135281 hasAuthorship W2110135281A5010859908 @default.
- W2110135281 hasAuthorship W2110135281A5049347564 @default.
- W2110135281 hasAuthorship W2110135281A5058668189 @default.
- W2110135281 hasConcept C119157973 @default.
- W2110135281 hasConcept C1491633281 @default.
- W2110135281 hasConcept C153911025 @default.
- W2110135281 hasConcept C167844969 @default.
- W2110135281 hasConcept C181199279 @default.
- W2110135281 hasConcept C185592680 @default.
- W2110135281 hasConcept C202751555 @default.
- W2110135281 hasConcept C203014093 @default.
- W2110135281 hasConcept C204258353 @default.
- W2110135281 hasConcept C2778903051 @default.
- W2110135281 hasConcept C2779244956 @default.
- W2110135281 hasConcept C2781184567 @default.
- W2110135281 hasConcept C28021979 @default.
- W2110135281 hasConcept C54355233 @default.
- W2110135281 hasConcept C55493867 @default.
- W2110135281 hasConcept C81885089 @default.
- W2110135281 hasConcept C86803240 @default.
- W2110135281 hasConceptScore W2110135281C119157973 @default.
- W2110135281 hasConceptScore W2110135281C1491633281 @default.
- W2110135281 hasConceptScore W2110135281C153911025 @default.
- W2110135281 hasConceptScore W2110135281C167844969 @default.
- W2110135281 hasConceptScore W2110135281C181199279 @default.
- W2110135281 hasConceptScore W2110135281C185592680 @default.
- W2110135281 hasConceptScore W2110135281C202751555 @default.
- W2110135281 hasConceptScore W2110135281C203014093 @default.
- W2110135281 hasConceptScore W2110135281C204258353 @default.
- W2110135281 hasConceptScore W2110135281C2778903051 @default.
- W2110135281 hasConceptScore W2110135281C2779244956 @default.
- W2110135281 hasConceptScore W2110135281C2781184567 @default.
- W2110135281 hasConceptScore W2110135281C28021979 @default.
- W2110135281 hasConceptScore W2110135281C54355233 @default.
- W2110135281 hasConceptScore W2110135281C55493867 @default.
- W2110135281 hasConceptScore W2110135281C81885089 @default.
- W2110135281 hasConceptScore W2110135281C86803240 @default.
- W2110135281 hasIssue "3" @default.
- W2110135281 hasLocation W21101352811 @default.
- W2110135281 hasLocation W21101352812 @default.
- W2110135281 hasOpenAccess W2110135281 @default.
- W2110135281 hasPrimaryLocation W21101352811 @default.
- W2110135281 hasRelatedWork W1548089074 @default.
- W2110135281 hasRelatedWork W1842696590 @default.
- W2110135281 hasRelatedWork W1976549993 @default.
- W2110135281 hasRelatedWork W2019234838 @default.
- W2110135281 hasRelatedWork W2028288720 @default.
- W2110135281 hasRelatedWork W2041091403 @default.
- W2110135281 hasRelatedWork W2110135281 @default.
- W2110135281 hasRelatedWork W2376602217 @default.
- W2110135281 hasRelatedWork W2582286870 @default.
- W2110135281 hasRelatedWork W593954733 @default.
- W2110135281 hasVolume "115" @default.
- W2110135281 isParatext "false" @default.
- W2110135281 isRetracted "false" @default.
- W2110135281 magId "2110135281" @default.
- W2110135281 workType "article" @default.