FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110136609> ?p ?o ?g. }

• W2110136609 endingPage "730" @default.
• W2110136609 startingPage "724" @default.
• W2110136609 abstract "Abstract Recent evidence indicates that human cytomegalovirus (HCMV) infection occurs in a high percentage of human malignant gliomas in vivo, as the HCMV immediate early-1 (IE1) protein is detected in &gt;90% of these tumors. The HCMV IE1 protein is essential for viral infection and has potent trans-activating and oncomodulatory properties. To investigate a potential role of HCMV in glioma biology, we stably expressed the HCMV IE1 gene product in immortalized and malignant human glial cells. Here we show that stable IE1 expression can differentially affect the growth of human glioblastoma cells, resulting in either growth proliferation or arrest. IE1 expression led to dysregulation of phosphatidylinositol 3-kinase/AKT activity, Rb phosphorylation, and expression of the p53 family of proteins. In U87 and U118 glioblastoma cells, IE1 induced cellular proliferation paralleled by reduction in steady-state expression level of Rb and p53 family proteins (including p53, p63, or p73) and simultaneous induction of the phosphatidylinositol 3-kinase/AKT signaling pathway. In contrast, IE1 expression in LN229 and U251 glioblastoma cells and immortalized human astrocytes was associated with increased expression of p53 family proteins, accompanied by growth arrest or lack of enhanced proliferation. Moreover, IE1 promoted cell cycle entry and DNA synthesis of human glioma cells on both stable expression in tumor-derived cell lines as well as transient expression in primary glioblastoma cells. These findings indicate that HCMV IE1 can significantly affect important oncogenic signaling pathways in glioblastoma cells. [Cancer Res 2008;68(3):724–30]" @default.
• W2110136609 created "2016-06-24" @default.
• W2110136609 creator A5007325825 @default.
• W2110136609 creator A5019173998 @default.
• W2110136609 creator A5022827061 @default.
• W2110136609 creator A5041193704 @default.
• W2110136609 creator A5083860351 @default.
• W2110136609 date "2008-02-01" @default.
• W2110136609 modified "2023-10-03" @default.
• W2110136609 title "Modulation of Oncogenic Phenotype in Human Glioma Cells by Cytomegalovirus IE1–Mediated Mitogenicity" @default.
• W2110136609 cites W1480917519 @default.
• W2110136609 cites W1556976811 @default.
• W2110136609 cites W1623819487 @default.
• W2110136609 cites W1845263582 @default.
• W2110136609 cites W187705992 @default.
• W2110136609 cites W1984828027 @default.
• W2110136609 cites W1997216271 @default.
• W2110136609 cites W2001544973 @default.
• W2110136609 cites W2008116181 @default.
• W2110136609 cites W2010592156 @default.
• W2110136609 cites W2024460705 @default.
• W2110136609 cites W2054776071 @default.
• W2110136609 cites W2061215313 @default.
• W2110136609 cites W2078861085 @default.
• W2110136609 cites W2086785691 @default.
• W2110136609 cites W2101182238 @default.
• W2110136609 cites W2109125050 @default.
• W2110136609 cites W2113942802 @default.
• W2110136609 cites W2118613565 @default.
• W2110136609 cites W2139068641 @default.
• W2110136609 cites W2153934725 @default.
• W2110136609 cites W2155140015 @default.
• W2110136609 cites W2339231403 @default.
• W2110136609 cites W4235658789 @default.
• W2110136609 doi "https://doi.org/10.1158/0008-5472.can-07-2291" @default.
• W2110136609 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18245472" @default.
• W2110136609 hasPublicationYear "2008" @default.
• W2110136609 type Work @default.
• W2110136609 sameAs 2110136609 @default.
• W2110136609 citedByCount "121" @default.
• W2110136609 countsByYear W21101366092012 @default.
• W2110136609 countsByYear W21101366092013 @default.
• W2110136609 countsByYear W21101366092014 @default.
• W2110136609 countsByYear W21101366092015 @default.
• W2110136609 countsByYear W21101366092016 @default.
• W2110136609 countsByYear W21101366092017 @default.
• W2110136609 countsByYear W21101366092018 @default.
• W2110136609 countsByYear W21101366092019 @default.
• W2110136609 countsByYear W21101366092020 @default.
• W2110136609 countsByYear W21101366092021 @default.
• W2110136609 countsByYear W21101366092022 @default.
• W2110136609 countsByYear W21101366092023 @default.
• W2110136609 crossrefType "journal-article" @default.
• W2110136609 hasAuthorship W2110136609A5007325825 @default.
• W2110136609 hasAuthorship W2110136609A5019173998 @default.
• W2110136609 hasAuthorship W2110136609A5022827061 @default.
• W2110136609 hasAuthorship W2110136609A5041193704 @default.
• W2110136609 hasAuthorship W2110136609A5083860351 @default.
• W2110136609 hasBestOaLocation W21101366091 @default.
• W2110136609 hasConcept C128473837 @default.
• W2110136609 hasConcept C184235292 @default.
• W2110136609 hasConcept C203014093 @default.
• W2110136609 hasConcept C2522874641 @default.
• W2110136609 hasConcept C2778227246 @default.
• W2110136609 hasConcept C2779820661 @default.
• W2110136609 hasConcept C502942594 @default.
• W2110136609 hasConcept C54355233 @default.
• W2110136609 hasConcept C62112901 @default.
• W2110136609 hasConcept C62478195 @default.
• W2110136609 hasConcept C75217442 @default.
• W2110136609 hasConcept C81885089 @default.
• W2110136609 hasConcept C86554907 @default.
• W2110136609 hasConcept C86803240 @default.
• W2110136609 hasConcept C95444343 @default.
• W2110136609 hasConceptScore W2110136609C128473837 @default.
• W2110136609 hasConceptScore W2110136609C184235292 @default.
• W2110136609 hasConceptScore W2110136609C203014093 @default.
• W2110136609 hasConceptScore W2110136609C2522874641 @default.
• W2110136609 hasConceptScore W2110136609C2778227246 @default.
• W2110136609 hasConceptScore W2110136609C2779820661 @default.
• W2110136609 hasConceptScore W2110136609C502942594 @default.
• W2110136609 hasConceptScore W2110136609C54355233 @default.
• W2110136609 hasConceptScore W2110136609C62112901 @default.
• W2110136609 hasConceptScore W2110136609C62478195 @default.
• W2110136609 hasConceptScore W2110136609C75217442 @default.
• W2110136609 hasConceptScore W2110136609C81885089 @default.
• W2110136609 hasConceptScore W2110136609C86554907 @default.
• W2110136609 hasConceptScore W2110136609C86803240 @default.
• W2110136609 hasConceptScore W2110136609C95444343 @default.
• W2110136609 hasIssue "3" @default.
• W2110136609 hasLocation W21101366091 @default.
• W2110136609 hasLocation W21101366092 @default.
• W2110136609 hasOpenAccess W2110136609 @default.
• W2110136609 hasPrimaryLocation W21101366091 @default.
• W2110136609 hasRelatedWork W2363685873 @default.
• W2110136609 hasRelatedWork W2793191352 @default.
• W2110136609 hasRelatedWork W2947842923 @default.
• W2110136609 hasRelatedWork W2995726900 @default.

• next