Matches in SemOpenAlex for { <https://semopenalex.org/work/W2110139320> ?p ?o ?g. }
- W2110139320 endingPage "1556" @default.
- W2110139320 startingPage "1545" @default.
- W2110139320 abstract "Thrombotic occlusion of the coronary artery, which triggers acute myocardial infarction, is one of the major causes of death in the USA. Currently, arterial occlusions are treated with intravenous plasminogen activators (PAs), which dissolve the clot by activating plasminogen. However, PAs indiscriminately generate plasmin, which depletes critical clotting factors (fibrinogen, factor V, and factor VIII), precipitates a lytic state in the blood, and produces bleeding complications in a large patient population. PAs have been extensively investigated to achieve thrombus specificity, to attenuate the bleeding risk, and to widen their clinical applications. In this review, we discuss various strategies that have been pursued since the beginning of thrombolytic therapy. We review the biotechnological approaches that have been used to develop mutant and chimeric PAs for thrombus selectivity, including the use of specific antibodies for targeting thrombi. We discuss particulate carrier-based systems and triggered-release concepts. We propose new hypotheses and strategies to spur future studies in this research arena. Overall, we describe the approaches and accomplishments in the development of patient-friendly and workable delivery systems for thrombolytic drugs." @default.
- W2110139320 created "2016-06-24" @default.
- W2110139320 creator A5007929409 @default.
- W2110139320 creator A5030145002 @default.
- W2110139320 creator A5033719812 @default.
- W2110139320 creator A5038625262 @default.
- W2110139320 date "2015-09-01" @default.
- W2110139320 modified "2023-09-30" @default.
- W2110139320 title "Engineering of plasminogen activators for targeting to thrombus and heightening thrombolytic efficacy" @default.
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